Polymorphous Low-Grade Adenocarcinoma in the Nasopharynx: A Case Report and Review of the Literature

Abstract

Polymorphous low-grade adenocarcinoma (PLGA) is a neoplasm that usually occurs in the minor salivary glands located in the mucosa of the soft and hard palates, the buccal mucosa, and the upper lip. It rarely occurs in the nasopharynx, and only six cases have been reported. PLGA can be treated by wide local excision and requires no additional treatment if a negative margin is identified in frozen biopsy. Here we describe a case of PLGA originating in the nasopharyngeal mucosa. We were able to completely resect the tumor using simple endoscopic surgery rather than using an open approach, such as a transpalatal resection. Our patient had no local recurrence or distant metastasis at the 24-month follow-up.

Stereotactic radiosurgery for recurrent skull base polymorphous adenocarcinoma invading the cavernous sinus: illustrative case

“… 3 , 5 , 6 However, PACs can sometimes extend into or metastasize to the skull base and the surrounding vital neurovascular structures, making the optimal radical treatment more difficult and invasive. 7 , 8 Because of the rarity of skull base PACs, it is difficult to establish a robust consensus on the treatment strategy.…”