Polymorphous Low Grade Adenocarcinoma of the Salivary Gland

Sáenz-Santamaría, Javier; Catalina-Fernández, Inmaculada

doi:10.1159/000326283

Cited by 22 publications

(17 citation statements)

References 10 publications

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“…Papillary/pseudopapillary fragments and three‐dimensional cellular aggregates composed of basaloid cells, clear at the periphery and acellular hyaline material clinch the diagnosis . The complexity in shapes of tumour cell aggregates in polymorphous adenocarcinoma is much more than ACC . Furthermore, the tumour cells of polymorphous adenocarcinoma are more uniform and larger than the cells of ACC.…”

Section: Discussionmentioning

confidence: 99%

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Adenoid cystic carcinoma: A study of 19 cases of salivary and extra‐salivary tumours diagnosed by fine needle aspiration cytology

Kundu

Handa

Punia

et al. 2018

Diagnostic Cytopathology

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Background Adenoid cystic carcinoma (ACC) arises at sites where seromucinous or sweat gland epithelium is present and commonly affects the salivary glands. Rarely it can occur at extra‐salivary locations. Methods A retrospective analysis of 19 cases of ACC diagnosed on fine needle aspiration cytology (FNAC) over a period of 15 y (2002‐2016) was made. Results Of 19 total cases, there were 10 salivary and 9 extra‐salivary ACCs. Extra‐salivary tumours were seen in 2 cases each in trachea, tongue and in one case each in bronchus, lung, subcutaneous tissue, maxillary antrum, and external auditory canal. The age ranged from 14‐80 y (mean: 49.5 y), 10 patients were male and 9 were female. The smears were highly cellular in 11 cases, moderately cellular in 5 cases while 3 cases were paucicellular. Multilayered dense clusters, tissue fragments, dispersed cells and cup‐shaped fragments were seen. Relatively uniform cells with high nuclear: cytoplasmic ratio, hyperchromatic nuclei, irregular margins, and nuclear moulding were observed. Variable sized hyaline globules, finger‐like hyaline material, hyaline cylinders, and hyaline cords were noted. The cytologic diagnosis of ACC was rendered in 13 cases while in 6 cases it was one of the differential diagnosis including monomorphic adenoma, membranous variant of basal cell adenoma, adnexal tumour, polymorphous adenocarcinoma, and pleomorphic adenoma (PA). Conclusions Cytologists must be aware of varied locations where ACC can occur. A diagnosis of ACC must not rely exclusively on the occurrence of hyaline globules but necessitates a close scrutiny of cellular and nuclear features to avoid diagnostic pitfalls.

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Section: Discussionmentioning

confidence: 99%

“…7 The complexity in shapes of tumour cell aggregates in polymorphous adenocarcinoma is much more than ACC. 17 (PA gene) as ACC is always immunonegative for PLAG1 while most PAs show immunopositivity. 23 Diffuse immunostaining for p63 seen in basaloid squamous cell carcinoma is helpful in delineating it from ACC.…”

Section: Discussionmentioning

confidence: 99%

Adenoid cystic carcinoma: A study of 19 cases of salivary and extra‐salivary tumours diagnosed by fine needle aspiration cytology

Kundu

Handa

Punia

et al. 2018

Diagnostic Cytopathology

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“…Aspiration cytology findings in polymorphous low grade adenocarcinoma of salivary glands may resemble pleomorphic adenoma and adenoid cystic carcinoma due to the mixture of epithelial and myoepithelial cells. Saenz‐Santamaria and Catalina Fernandez22 emphasized the evaluation of all subtle cytologic features in the aspiration cytology of polymorphous low grade adenocarcinoma. Epithelial‐myoepithelial carcinoma is another rare tumor which usually involves the parotid gland.…”

Section: Discussionmentioning

confidence: 99%

The cell with a thousand faces: Detection of myoepithelial cells and their contributions in the cytological diagnosis of salivary gland tumors

Avcı¹,

Günhan

Çakalağaoğlu³

et al. 2010

Diagnostic Cytopathology

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Myoepithelial cells are an important component of salivary gland tumors and are partly responsible from the diverse histology of them. In this study, we focus on the myoepithelial cell differentiation by using cytological morphology in a various types of salivary gland tumors especially with regard to their contribution to the diagnosis. The relation of myoepithelial cells with stromal matrix and the associated epithelial cells were evaluated. Cytologic slides of one hundred and forty one benign and twenty malignant salivary gland tumors were examined for identification of morphologically different myoepithelial cells such as; spindle-stellate, polygonal-epitheloid, plasmacytoid, basal and clear types. The best examples of myoepithelial cells were detected in pleomorphic adenomas, in some monomorphic adenomas and in the adenoid cystic carcinoma cases. Most of the pleomorphic adenomas were composed more than one type of myoepithelial cells and epitheloid-spindle cell combination was frequent. Basal and clear cell types of myoepithelial cells closely resembled the epithelial cells and their identification was relatively difficult. Identification of myoepithelial cell types was easier when they were associated with stromal matrix material and stood as a secondary layer around tubule-forming epithelial cells. Myoepithelial cell components of various salivary gland tumors may be quite different and identification of myoepithelial cell types may pose difficulties. A confident cytologic identification of myoepithelial cells may be critical part of diagnosing salivary gland tumors.

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“…Other tumours that can present hyaline globules should also be considered in the differential diagnosis of canalicular adenoma, including the polymorphous low‐grade adenocarcinoma and epithelial–myoepithelial carcinoma 12 . The former has cells with bland cytological features, a moderate amount of cytoplasm and medium‐sized nuclei, 12,17 while the latter consists of medium‐sized to large cells with abundant cytoplasm and atypical nuclei 12 . In our two cases, the lesions showed small cells with round to oval bland nuclei and scanty cytoplasm, eliminating both a polymorphous low‐grade adenocarcinoma and an epithelial–myoepithelial carcinoma as possible diagnoses.…”

Section: Discussionmentioning

confidence: 99%