Polymorphs and pharmacokinetics of an antipsychotic drug candidate

Polymorphism, phase transition, and physicochemical property investigation of Ensifentrine

“…[1][2][3][4][5] Owing to the variations in molecular packing, polymorphs of active pharmaceutical ingredients (APIs) often have varying physicochemical characteristics. [6][7][8][9][10][11][12][13][14] During the process of finding and developing new drugs, it is crucial to plan ahead and choose the best form. Therefore, it is necessary to be aware of as many forms as possible in order to choose the best one.…”

Exploration and investigation of various solid forms of an anti-glaucoma drug – dichlorphenamide

“…[1][2][3][4][5][6] The development of polymorphs can be caused by a number of reaction conditions, including a variety of temperatures, solvents, pressures or the presence of impurities or additives. [7][8][9][10][11][12][13][14][15][16] Due to their diverse packing modes, polymorphic structures exhibit various physical and chemical properties as well as various biological activities. [17][18][19][20][21][22][23][24] Consequently, polymorph management is a major issue for both industry and research, posing significant economic and scientific obstacles.…”

Tuning Potency of Bioactive Molecules via Polymorphic Modifications: A Case Study

“…In the case of medicinal compounds, active pharmaceutical ingredients (API), and drugs, pre-formulation analysis of the solid polymorphs and their systematic characterizations are crucial. The diversity in properties is usually observed in the solid state forms and in some cases in solution. , Although the characterizations of polymorphs based on their solid-state properties have been studied extensively, in-solution properties, e.g., bioavailability and bioactivity, are the least explored. In this context, the CrystalExplorer-based Hirshfeld surface analysis has emerged as a useful tool for characterizing polymorphic crystal structures .…”