Polymyxin B-targeted liposomal photosensitizer cures MDR A. baumannii burn infections and accelerates wound healing via M1/M2 macrophage polarization

Cui, Zixin; Li, Yiyang; Qin, Yannan; Li, Jianzhou; Shi, Lei; Wan, Meijuan; Hu, Min; Chen, Yunru; Ji, Yanhong; Hou, Yuzhu; Ye, Feng; Liu, Chengcheng

doi:10.1016/j.jconrel.2023.12.046

Cited by 8 publications

(2 citation statements)

References 68 publications

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“…Herein, a PMB-modified conjugated oligomer (CON) designed by Jiang et al could induce synergistic PDT to kill kanamycin-resistant E. coli under white light . Also, Cui et al leveraged PMB-decorated liposome as a targeting drug delivery platform to load with PS hemato-porphyrin monomethyl ether (HMME) . The satisfactory bactericidal effect and excellent anti-inflammatory capacity of HMME@Lipo-PMB hold its promise of being a potent weapon in the treatment of burn infections caused by MDR A. baumannii .…”

Section: Photodynamic Therapy-based Targeted Strategymentioning

confidence: 99%

“…In line with PMB's antibacterial mechanism, both flow cytometry analyses and CLSM images exhibited that PMB-modified porphyrin had a higher affinity for G − P. aeruginosa than G + S. aureus. 76 78 The satisfactory bactericidal effect and excellent anti-inflammatory capacity of HMME@Lipo-PMB hold its promise of being a potent weapon in the treatment of burn infections caused by MDR A. baumannii.…”

Section: Conjugating Pss With Antibacterial Substancesmentioning

confidence: 99%

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Photochemical Strategies toward Precision Targeting against Multidrug-Resistant Bacterial Infections

Yu,

Wang,

Zhang

et al. 2024

ACS Nano

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Infectious diseases pose a serious threat and a substantial economic burden on global human and public health security, especially with the frequent emergence of multidrug-resistant (MDR) bacteria in clinical settings. In response to this urgent need, various photobased anti-infectious therapies have been reported lately. This Review explores and discusses several photochemical targeted antibacterial therapeutic strategies for addressing bacterial infections regardless of their antibiotic susceptibility. In contrast to conventional photobased therapies, these approaches facilitate precise targeting of pathogenic bacteria and/or infectious microenvironments, effectively minimizing toxicity to mammalian cells and surrounding healthy tissues. The highlighted therapies include photodynamic therapy, photocatalytic therapy, photothermal therapy, endogenous pigments-based photobleaching therapy, and polyphenols-based photo-oxidation therapy. This comprehensive exploration aims to offer updated information to facilitate the development of effective, convenient, safe, and alternative strategies to counter the growing threat of MDR bacteria in the future.

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Section: Photodynamic Therapy-based Targeted Strategymentioning

confidence: 99%

Section: Conjugating Pss With Antibacterial Substancesmentioning

confidence: 99%