Abstract:Antibiotic resistance in Gram‐negative pathogenic bacteria has reached alarming levels and these drug‐resistant bacteria pose an urgent global threat. All of the major classes of antibiotics with activity against Gram‐negative bacteria, including penicillins, cephalosporins, carbapenems, aminoglycosides, quinolones, and tetracyclines, have over time succumbed to widespread resistance. Fortunately, medicinal chemistry has been very successful at iteratively addressing the emergence of resistance (and other limi… Show more
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