Polyneuropathy and Folate Deficiency

Botez, M.I.; Peyronnard, Jean‐Marie; Bachevalier, Jocelyne; Charron, Louise

doi:10.1001/archneur.1978.00500330029005

Cited by 64 publications

(36 citation statements)

References 9 publications

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“…Neuropathy was observed in the lower extremities more severely than the upper extremi ties. Sensory axonopathy was dominant in the folate de ficient neuropathy demonstrated electrophysiologically, consistent with previous reports (12,22), while multi variate analysis did not detect any differences among subtypes of folate-deficient neuropathy. Axonopathy re sponded more readily to folate therapy, suggesting that axonopathy is a prototype of folate-deficient neuropathy which can be modified by other factors concomitant with diseases, leading to demyelination.…”

Section: Discussionsupporting

confidence: 91%

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Folic Acid-Responsive Neurological Diseases in Japan.

Yukawa

Naka

Murata

et al. 2001

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryFolic acid (folate) levels were measured in the serum of patients with various neurological diseases in Japan. Thirty-six patients showed decreased serum folate levels among 343 consecutive neurological patients (10.5%). Folate administration (15mg/d) to folate-deficient patients improved neurological symptoms in 24 of 36 cases (67%). Serum folate levels were significantly lower in female than in male folate-deficient patients. Folate deficient patients showed predominantly axonal neuropathy, which responded to folate sup plementation more markedly. Male patients more frequently exhibited neuropathy, espe cially demyelinating and motor-dominant neuropathy, than females. Anemia was corre lated with male sex and low serum folate levels. Male patients were more responsive than fe males to folate treatment. More male patients had taken excess alcohol or received gastrec tomies than females. Neurological symptoms were more frequently improved by folate sup plementation in patients with neuropathy than exclusive encephalopathy. Serum folate lev els were lower in patients with encephalopathy, especially those with dementia, while folate therapy was more effective in neurological patients without dementia. Dysgeusia and ane mia improved in all patients after folate administration. Neurological patients with malab sorption or treated with continuous drip infusion were resistant to folate therapy. Since fo late-responsive neuroencepahlopathies are not rare among patients with neurological dis eases in Japan, the serum folate level would serve as a valuable indicator for folate supple ment therapy.

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Section: Discussionsupporting

confidence: 91%

“…The major causes of folate deficiency found in this study were disorders in the GI tract, excessive alcohol intake or anticonvulsants as described previously (12,18,19). In addition, we found 8 neurological patients without previously reported causes (20)(21)(22).…”

Section: Discussionmentioning

confidence: 70%

Folic Acid-Responsive Neurological Diseases in Japan.

Yukawa

Naka

Murata

et al. 2001

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Folate is an important dietary vitamin, and its deficiency in humans is associated with several diseases (Botez et al 1978, Kim 2005, Burren et al 2008. Folate deprivation has also been implicated in early pregnancy loss (Ronnenberg et al 2007) and recurrent spontaneous abortions (Sutterlin et al 1997, George et al 2002.…”

Section: Introductionmentioning

confidence: 99%

Expression of DNA methyltransferases in the mouse uterus during early pregnancy and susceptibility to dietary folate deficiency

Ding

He²,

Liu³

et al. 2012

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We have characterized the uterine expression of DNA methyltransferases (DNMTs) during early pregnancy in mice and determined whether a folate-deficient diet (FDD) can affect DNMTs in this context. Within endometrial cells, expressions of DNMT (cytosine-5) 1 (Dnmt1),Dnmt3a, andDnmt3bwere significantly elevated during the prereceptive phase of pregnancy but generally returned to baseline levels during receptive and postimplantation periods. As such, the transcription of DNMT genes is temporally regulated during early pregnancy. When comparisons were made between implantation sites (IS) and inter-IS on day 5 of pregnancy, lower levels ofDnmt3awere detected at IS. Comparisons between IS and inter-IS did not reveal significant expression differences for other DNMT genes. When tissue sections were examined, DNMT3A was specifically lower in the stroma of IS. Reduced DNMT1 and DNMT3B levels were also observed in the luminal and glandular epithelia of IS, whereas no obvious differences in the stroma were detected. In pseudo-pregnant mice subjected to a FDD, levels ofDnmt1andDnmt3a(but notDnmt3b) were significantly upregulated in endometrial tissues, as compared with controls. When tissues from these folate-deficient mice were examined, DNMT1 levels were elevated in both the luminal and glandular epithelia, whereas DNMT3A was upregulated in the luminal epithelium and the stroma. A slight increase in DNMT3B levels was detected in the glandular epithelium. These results indicate that DNMTs may regulate the transcription of endometrial genes associated with embryo implantation and that levels of DNMTs are affected by dietary folate in mice.

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“…Neurologische Veränderungen sind zwar beim Vitamin-B12-Mangel häufiger, wurden aber auch beim Folsäuremangel beschrieben [36][37][38]. Häufigste Ursache des Folsäuremangels ist eine Fehlernährung, insbesondere eine mangelnde Einnahme von Obst, Gemüse und tierischen Proteinen.…”

Section: Folsäuremangelunclassified

Anämieabklärung (Teil 1)

Peghini¹,

Fehr²

2002

Swiss Med Forum

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Polyneuropathy and Folate Deficiency

Cited by 64 publications

References 9 publications

Folic Acid-Responsive Neurological Diseases in Japan.

Folic Acid-Responsive Neurological Diseases in Japan.

Expression of DNA methyltransferases in the mouse uterus during early pregnancy and susceptibility to dietary folate deficiency

Anämieabklärung (Teil 1)

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