In this paper, we consider a mixed problem for the nonlinear wave equations with transmission acoustic conditions, that is, the wave propagation over bodies consisting of two physically different types of materials, one of which is clamped.We prove the existence, uniqueness, and exponential stability of global solutions for this problem. KEYWORDS exponential stability of global solutions, locally reacting boundary, nonlinear wave equation, transmission acoustic conditions Math Meth Appl Sci. 2018;41:7055-7073.wileyonlinelibrary.com/journal/mma