Polynuclear Aluminium and Acute Aluminium Toxicity in the Fish

Exley, Christopher; Wicks, A. J.; Hubert, Rupert B.; Birchall, J. D.

doi:10.1006/jtbi.1994.1081

Cited by 21 publications

(15 citation statements)

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“…If it did form, however, it would probably not be stable for a long enough time to exert any toxicity (Furrer et al 1992). Added to this fact is that the only experiment that directly compared the toxicities of Al 3+ and Al 13 7+ in a steady-state system showed no significant toxicity for the polymeric form (Exley et al 1994). Finally, Exley et al (1996) suggested that the acute toxicity evoked under non-steady-state conditions was due to the diffusion of small Al polymers into the mucus matrix, which resulted in tanning of mucus by Al crosslinking the mucus glycocalyx.…”

Section: Effects Of a Transient Al Chemistrymentioning

confidence: 99%

Effect of unstable aluminium chemistry on Arctic char (Salvelinus alpinus)

Poléo¹,

Bjerkely²

2000

Can. J. Fish. Aquat. Sci.

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Arctic char (Salvelinus alpinus) were exposed to a non-steady-state Al-rich medium (pH 5.8, total Al 480 mg·L -1 , total organic C 3.0 mg C·L -1 , Ca 2+ 2.9 mg·L -1 , temperature 7.5°C). An Al-poor medium (pH 5.2 and 5.8, total Al 99 mg·L -1 , total organic C 3.0 mg C·L -1 , Ca 2+ 2.9 mg·L -1 , temperature 8.0°C) acted as control. The Al-rich medium was acutely toxic to the Arctic char. Total mortality (percent) and mortality rate (LT 50 ) were highest in fish exposed to the Al-rich medium immediately after mixing and decreased systematically with water residence time (e.g., from 65 h at 1 min to 124 h at 3 min to more than 400 h at 15 min). Gill morphology changes, Al gill deposition, and haematological parameters revealed significant effects of Al, which all correlated with water residence time. Signs of acclimation or high difference in Al tolerance between individuals were observed. This indicates that effects of Al in fish are dependent on the degree of Al polymerisation and supports earlier indications that Arctic char are relatively tolerant of acidic Al-rich water.Résumé : Des spécimens d'omble chevalier (Salvelinus alpinus) ont été exposés à un milieu non stationnaire riche en aluminium (pH 5,8, Al total 480 mg·L -1 , carbone organique total (COT) 3,0 mg C·L -1 , Ca 2+ 2,9 mg·L -1 , temperature 7,5°C). Un milieu pauvre en Al (pH 5,2 et 5,8, Al total 99 mg·L -1 , COT 3,0 mg C·L -1 , Ca 2+ 2,9 mg·L -1 , temperature 8,0°C) servait de témoin. Le milieu riche en Al s'est révélé d'une toxicité aiguë pour l'omble chevalier. La mortalité totale (%) et le taux de mortalité (TL 50 ) étaient les plus élevés chez les poissons exposés au milieu riche en Al juste après le mélange, puis baissaient systématiquement avec la durée du séjour dans l'eau (p. ex. de 65 h à 1 min, 124 h à 3 min, à plus de 400 h à 15 min). Des changements dans la morphologie des branchies, le dépôt d'Al sur les branchies et les paramètres hématologiques révélaient des effets significatifs de l'aluminium, qui étaient tous corrélés avec la durée du séjour dans l'eau. On a observé des signes d'acclimatement ou une nette différence dans la tolérance à Al d'un individu à l'autre. Cela indique que les effets de l'aluminium chez les poissons dépendent du degré de polyméri-sation favorisé par ce métal, et confirme que l'omble chevalier tolère relativement bien les eaux acides riches en Al.[Traduit par la Rédaction] 1433Poléo and Bjerkely

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Section: Effects Of a Transient Al Chemistrymentioning

confidence: 99%

Effect of unstable aluminium chemistry on Arctic char (Salvelinus alpinus)

Poléo¹,

Bjerkely²

2000

Can. J. Fish. Aquat. Sci.

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“…Of course, our proposal explanation could primarily discuss the activating effects of Al species on the activity of MDH. However, it is indeed true that aqueous Al would have undergone a process of ongoing Al polymerization, and the toxicity of aluminum is a matter of reaction kinetics, where the degree of ongoing Al polymerization is the most important [50], so it is both significant and valuable to explore more thoroughly the mechanism.…”

Section: Resultsmentioning

confidence: 99%

Effects of Al(III) and Nano-Al13 Species on Malate Dehydrogenase Activity

Yang

Cai

Peng

et al. 2011

Sensors

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The effects of different aluminum species on malate dehydrogenase (MDH) activity were investigated by monitoring amperometric i-t curves for the oxidation of NADH at low overpotential using a functionalized multi-wall nanotube (MWNT) modified glass carbon electrode (GCE). The results showed that Al(III) and Al13 can activate the enzymatic activity of MDH, and the activation reaches maximum levels as the Al(III) and Al13 concentration increase. Our study also found that the effects of Al(III) and Al13 on the activity of MDH depended on the pH value and aluminum speciation. Electrochemical and circular dichroism spectra methods were applied to study the effects of nano-sized aluminum compounds on biomolecules.

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“…Exley & Birchall (1996) cite principally Exley et al (1994) in support of their contention that the toxicity to fish exhibited by 10 IM Al solutions at pH 5 is due to direct binding of the A13+ cation to the gill membrane. Exley et al (1994) found that solutions containing the AII3 polycation at pH 5 were less toxic to brown trout fry than the solutions prepared to contain predominantly the A13+ cation at pH 5.…”

mentioning

confidence: 98%