Polyoma virus infection is a prominent risk factor for bladder carcinoma in immunocompetent individuals

Weinreb, B B A David; Desman, Garrett; Amolat-Apiado, May Jennifer M.; Burstein, David; Godbold, James; Johnson, Edward M.

doi:10.1002/dc.20429

Cited by 57 publications

(56 citation statements)

References 17 publications

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“…Weinreb et al (2006) reported a significant association between urine cytology suggestive of PV infection and subsequent diagnosis of bladder carcinoma. However, this study did not confirm PV positivity with IH and the urinary findings may have been secondary to early urothelial carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Polyoma virus infection and urothelial carcinoma of the bladder following renal transplantation

et al. 2008

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Renal transplant recipients are at increased risk of bladder carcinoma. The aetiology is unknown but a polyoma virus (PV), BK virus (BKV), may play a role; urinary reactivation of this virus is common post-renal transplantation and PV large T-antigen (T-Ag) has transforming activity. In this study, we investigate the potential role of BKV in post-transplant urothelial carcinoma by immunostaining tumour tissue for PV T-Ag. There was no positivity for PV T-Ag in urothelial carcinomas from 20 non-transplant patients. Since 1990, 10 transplant recipients in our unit have developed urothelial carcinoma, and tumour tissue was available in eight recipients. Two patients were transplanted since the first case of PV nephropathy (PVN) was diagnosed in our unit in 2000 and both showed PV reactivation post-transplantation. In one of these patients, there was strong nuclear staining for PV T-Ag in tumour cells, with no staining of non-neoplastic urothelium. We conclude that PV infection is not associated with urothelial carcinoma in non-transplant patients, and is uncommon in transplant-associated tumours. Its presence in all tumour cells in one patient transplanted in the PVN era might suggest a possible role in tumorigenesis in that case.

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Section: Discussionmentioning

confidence: 99%

Polyoma virus infection and urothelial carcinoma of the bladder following renal transplantation

et al. 2008

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“…A recent cross-sectional study of immunocompetent patients undergoing urinary cytologic analyses demonstrated a statistically significant association between polyomavirus infection and bladder cancer. 24 In contrast, a prospective study observed no association between serum antibodies to BKV measured at baseline and subsequent bladder cancer diagnosed an average of 1.4 years later, based on 9 incident bladder cancer cases. 25 Previous bladder tumor studies have been limited by small sample size and lack of paired normal tissues.…”

mentioning

confidence: 92%

Lack of BK virus DNA sequences in most transitional‐cell carcinomas of the bladder

Rollison¹,

Sexton²,

Rodríguez³

et al. 2006

Intl Journal of Cancer

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BK virus (BKV), a common human polyomavirus infection latent in the kidneys, can reactivate with immunosuppression to cause renal disease. Some have suggested that BKV may contribute to the development of bladder cancer, and BKV sequences have been reported from bladder tumors. To further examine the role of BKV in human bladder cancer, a series of bladder tumors was investigated for BKV genomic sequences. Fresh‐frozen specimens from 76 transitional cell carcinoma tissues and 46 paired adjacent normal urothelial tissues archived at the H. Lee Moffitt Cancer Center were studied. All tissues were histopathologically reviewed. DNA extracted from the tissues was tested by quantitative real‐time polymerase chain reaction (QPCR) assays to detect BKV DNA sequences in the VP1 coding region. Amplification of ERV‐3 was conducted separately to quantify cell copy number. Conventional PCR targeting the BKV T‐antigen (T‐Ag) coding region and immunohistochemistry for BKV T‐Ag were also conducted on all tissues that tested positive for BKV by QPCR. Seventy‐three bladder tumors yielded ≥3,000 copies of ERV‐3, 4 (5.5%) of which tested positive for BKV with average copy numbers of 7.9, 15.8, 0.4 and 0.3 per 1,000 cells. Paired normal tissue was available for 2 of these BKV‐positive tumors, 1 of which was BKV‐positive (14.6 copies/1,000 cells). No other normal tissues were BKV‐positive by QPCR. The 6 BKV‐positive tissues by QPCR were also positive by conventional PCR, but all stained negative for BKV T‐Ag by immunohistochemistry. BKV is unlikely to be involved in the etiology of most bladder tumors. © 2006 Wiley‐Liss, Inc.

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“…Finally, Weinreb et al (2006) identified a population of patients with PV-infected 'decoy' cells seen on urine cytologic analysis. The incidence of bladder carcinoma in this population was significantly higher than in patients receiving urine cytologic analysis but lacking any such infected cells.…”

Section: Sirmentioning

confidence: 99%

BK virus and carcinoma of the prostate, kidney and bladder

Weinreb

2006

Br J Cancer

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Polyoma virus infection is a prominent risk factor for bladder carcinoma in immunocompetent individuals

Cited by 57 publications

References 17 publications

Polyoma virus infection and urothelial carcinoma of the bladder following renal transplantation

Polyoma virus infection and urothelial carcinoma of the bladder following renal transplantation

Lack of BK virus DNA sequences in most transitional‐cell carcinomas of the bladder

BK virus and carcinoma of the prostate, kidney and bladder

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