Polyomavirus SV40: Model Infectious Agent of Cancer

Butel, Janet S.

doi:10.1007/978-1-4614-0016-5_15

Cited by 11 publications

(22 citation statements)

References 175 publications

(199 reference statements)

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“…The Lederle candidate vaccine strains were tested in Central and South America and in Florida. The Koprowski candidate vaccine was tested in Poland, Croatia, and the Belgian Congo [19–23]. Other vaccine tests were conducted as well.…”

Section: History Of Use Of Sv40-contaminated Vaccinesmentioning

confidence: 99%

“…Many reports in the literature over the last two decades have detected SV40 markers in noncancer samples from healthy children and adults (Box 1), including in urine, stool, blood, and lymphoid tissues [23]. Studies have included subjects from the US, Europe, Japan, Egypt, and Russia.…”

Section: Evidence Of Sv40 Infections In Humansmentioning

confidence: 99%

“…However, the observed prevalence of SV40 has varied widely among reported studies and the associations detected with tumors do not prove causality. (See Butel [23,34] for original references. )…”

Section: Evidence Of Sv40 Infections In Humansmentioning

confidence: 99%

“…Estimates of SV40 prevalences have been from 2% to greater than 10% in different groups [23,27,28]. Neutralization assays are highly specific, but are too labor-intensive and time-consuming to apply to large population surveys for SV40.…”

Section: Serological Findingsmentioning

confidence: 99%

“…A number of studies have found evidence linking SV40 with human tumors, with the most commonly associated tumor types being brain tumors, mesotheliomas, osteosarcomas, and lymphomas [23,31–34]. Studies involving lymphomas are summarized in Table 2.…”

Section: Association Of Sv40 With Human Cancermentioning

confidence: 99%

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Patterns of polyomavirus SV40 infections and associated cancers in humans: a model

Butel

2012

Current Opinion in Virology

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A model is described that predicts patterns of polyomavirus SV40 infections and associated cancers in humans. The model proposes that SV40 infections were established in humans primarily by exposure to contaminated oral poliovaccines and that infections persist today in geographic regions where poor sanitation or living conditions allow maintenance of infections transmitted by a fecal/urine–oral route. Predictions from the model include that SV40 infections and virus-associated malignancies will be restricted geographically and demographically and that in developed countries, such as the US, SV40 prevalence rates will be generally very low. The model highlights the importance of selection of populations for investigations of SV40 human infections. This model can explain inconsistencies in the published literature of SV40 infections in humans and can guide the design of future studies.

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Section: History Of Use Of Sv40-contaminated Vaccinesmentioning

confidence: 99%

Section: Evidence Of Sv40 Infections In Humansmentioning

confidence: 99%

Section: Evidence Of Sv40 Infections In Humansmentioning

confidence: 99%

Section: Serological Findingsmentioning

confidence: 99%

Section: Association Of Sv40 With Human Cancermentioning

confidence: 99%

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Patterns of polyomavirus SV40 infections and associated cancers in humans: a model

Butel

2012

Current Opinion in Virology

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In vivo detection of polyomaviruses JCV and SV40 in mesenchymal stem cells from human umbilical cords

Comar

Delbue

Zanotta

et al. 2014

Pediatric Blood & Cancer

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Ethnic differences in polyomavirus simian virus 40 seroprevalence among women in Houston, Texas

Wong¹,

Vilchez²,

Quiroz³

et al. 2013

Journal of Infection

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Objective To examine the prevalence and distribution among racial/ethnic groups of polyomavirus SV40 antibodies in women in Houston, Texas. Methods Women in three different cohorts reflecting the evolving demographics of Houston were evaluated for frequency of SV40 antibodies using a plaque-reduction neutralization assay. Results Women in cohort A (enrolled 1972–1973) were 68% (145/212) African-American and 32% Caucasian; the overall frequency of SV40 neutralizing antibodies was 7%. Women in cohort B (enrolled 1975–1977) were Caucasian with an overall frequency of SV40 neutralizing antibodies of 18% (37/211). Women in cohort C (enrolled 1993–1995) were 50% (199/400) African-American, 25% Caucasian, and 25% Hispanic; the overall frequency of SV40 neutralizing antibodies was 10%. Logistic regression analysis for cohort A showed no difference in SV40 neutralizing antibodies with respect to race/ethnicity, pregnancy status, number of previous pregnancies, or history of sexually transmitted diseases. For cohort C, race/ethnicity was identified as a significant factor associated with SV40 neutralizing antibodies, with Hispanics having a seroprevalence of 23% compared to 5–6% in the other two groups (p = 0.01). Conclusions A significantly higher SV40 seroprevalence was found among Hispanics than other racial/ethnic groups in the city of Houston. Findings are compatible with a model that certain population groups potentially exposed to SV40-contaminated oral poliovaccines have maintained cycles of SV40 infections.

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Polyomavirus SV40: Model Infectious Agent of Cancer

Cited by 11 publications

References 175 publications

Patterns of polyomavirus SV40 infections and associated cancers in humans: a model

Patterns of polyomavirus SV40 infections and associated cancers in humans: a model

In vivo detection of polyomaviruses JCV and SV40 in mesenchymal stem cells from human umbilical cords

Ethnic differences in polyomavirus simian virus 40 seroprevalence among women in Houston, Texas

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