Polyostotic Paget’s disease of bone: Diagnostic dilemma in detection of bone metastases from prostate cancer

Ilinčić, Branislava; Crnobrnja, Veljko; Mijović, Romana; Žeravica, Radmila; Jakovljevic, Ana; Kadic, Vuk

doi:10.2298/mpns1208337i

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…Among the previously published cases that reported coexistence of PDB and metastatic bone disease, the primary sites of malignancy were the breast, lung, and prostate. [18][19][20][21] In our patient, the final diagnosis of metastatic bone disease secondary to adenocarcinoma of the lung was found after PDB was diagnosed by bone biopsy. As illustrated in the case, three modalities, including radiography, bone biopsy and 18 F-FDG PET/CT were utilized in the diagnostic process.…”

Section: Discussionmentioning

confidence: 85%

Metastatic Bone Disease Secondary to Bronchial Adenocarcinoma in a Patient with Paget’s Disease of the Bone

Lim

Kok

Kamaruddin

2018

JAFES

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A 69-year-old female complained of intermittent left hip pain for the past 3 years. Biochemical tests revealed normal serum calcium and phosphorus with markedly raised alkaline phosphatase. MRI of the hip revealed extensive marrow signal abnormalities at the left pelvic bone, while CT of the thorax revealed a spiculated lung nodule at the left lower lung lobe. In order to diagnose either primary, metastatic bone tumour or Paget's disease of the bone (PDB), an open biopsy of the left iliac bone was performed. The histopathology of bone biopsy of the left iliac bone was consistent with PDB. A CT guided biopsy of the lung mass done later revealed adenocarcinoma of the lung. She had 18 F-FDG PET-CECT Scan for staging evaluation and result was suggestive of new bony metastases. Patient was started on IV Zoledronic acid for treatment of the PDB. In view of the stage 4 lung adenocarcinoma with bony metastases, patient was scheduled for palliative chemotherapy.

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Section: Discussionmentioning

confidence: 85%

Metastatic Bone Disease Secondary to Bronchial Adenocarcinoma in a Patient with Paget’s Disease of the Bone

Lim

Kok

Kamaruddin

2018

JAFES

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“…[6] However, patients with Paget's disease presenting subsequently with bony metastasis is rarely reported. [7]…”

Section: Discussionmentioning

confidence: 99%

“…Among the previously published cases, the primary sites of malignancy in patients with Paget's disease were the breast, lung, and prostate. [789]…”

Section: Discussionmentioning

confidence: 99%

An unusual presentation of metastatic bone disease in a subject with Paget's disease of bone

Shetty

Prabhu

et al. 2016

J Family Med Prim Care

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Solid organ malignancies involving breast, prostate, and lung frequently metastasize to the skeleton. However, the occurrence of Paget's disease and metastatic bone disease in the same patient is uncommon. We report a case of a 63-year-old man who presented with back pain and a lump in the right breast. He was earlier diagnosed to have Paget's disease of bone based on characteristic skeletal radiological features,99mTc methylene diphosphonate bone scan and elevated alkaline phosphatase, and treated with bisphosphonates, and his disease was in remission. Further evaluation revealed an underlying skeletal metastatic disease secondary to a breast malignancy. He underwent radical mastectomy with axillary node clearance, radiotherapy, and chemotherapy. In addition, he also received parenteral bisphosphonates for his skeletal metastatic bone disease.

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Polyostotic Paget’s disease of bone: Diagnostic dilemma in detection of bone metastases from prostate cancer

Abstract: Metastatic bone lesions, in this case from prostate cancer, and asymptomatic Paget's disease may closely resemble each other. They both need careful evaluation in order to determine the proper stages of malignant disease and selection of appropriate therapies for patients.

Cited by 2 publications

References 8 publications

Metastatic Bone Disease Secondary to Bronchial Adenocarcinoma in a Patient with Paget’s Disease of the Bone

Metastatic Bone Disease Secondary to Bronchial Adenocarcinoma in a Patient with Paget’s Disease of the Bone

An unusual presentation of metastatic bone disease in a subject with Paget's disease of bone

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