Polyoxometalate entrapped caprolactam gels and their cytotoxicity study

Abstract

Polyoxometalate (POM) based gels are synthesized by reacting POMs with an excess of caprolactam. These POM-entrapped caprolactam gels are thermoreversible and possess good mechanical strength. The gelation of POMs in caprolactam matrix brought the gel acidity similar to the physiological pH. The cytotoxicity studies on SCC 131 cell lines using these gels show 50% of cell death in the range of 2 to 6 mM concentration in 48 h. The supramolecular caprolactam matrix with active protons and the redox property of POMs are responsible for the cytotoxicity effect.

Polyoxometalate‐Containing Supramolecular Gels

“…[46,47] Another important interaction in POM-containing supramolecular gels is hydrogen bonding, which commonly plays a key role in the system comprising of POMs and neutral organic molecules such as amino acids and peptide. [48,49] As a relative strong supramolecular interaction, a coordination bond is also powerful for building POM-containing gels in the presence of transition or rareearth metal ions. [50,51] In this case, the coordination bonds not only form between metal ions with O atoms on the surface of the cluster but also existing metal ions with N atom sourcing from functional groups anchoring on the cluster.…”

Polyoxometalates as components of supramolecular assemblies

“…Also the feasibility of implanting the Keggin-type POMs (H 3 PM 12 O 40 , M = Mo, W) into a caprolactam matrix was reported. It was shown that decreasing the POM/caprolactam ratio enforces transformation of the resulting hybrid material from the solid to the gel-like state 85…”

Facile Preparation and Controllable Absorption of a Composite Based on PMo12/Ag Nanoparticles: Photodegradation Activity and Mechanism”

“…Both the separation and stability of the reaction process become the main problem in practical application, which greatly limits their further application in the field of photocatalysis [11,16–18] . Therefore, one rather considerable strategy is focusing on the coupling POMs with a sensitizer which is light‐collecting antennas that can capture visible light and thus improve photocatalysis performance [19,20] …”