Polyoxometalate nanomaterials for enhanced reactive oxygen species theranostics

Liu, Jiale; Huang, Mengyao; Zhang, Xinyu; Hua, Zhongyu; Feng, Zeran; Dong, Yi; Sun, Tiedong; Sun, Xiao; Chen, Chunxia

doi:10.1016/j.ccr.2022.214785

Cited by 51 publications

(19 citation statements)

References 253 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polyoxometalates (POMs) are anionic metal-oxide clusters with diverse nuclearities, modifiable oxygen-rich surfaces, and accessible organic grafting. , They have strong thermal stability, high negative charges, and remarkable redox abilities. These POM derivatives have been widely applied in areas ranging from electrochemistry to photochromism, medicine, and magnetism, − particularly exhibiting excellent catalytic performance due to their satisfying Lewis acidity and charge accumulation capability. , The incorporation of POMs into well-defined architectures produced another level of complexity with interesting behavior, not only the unique structure and functional features of POMs could be passed to the target materials, but also synergetic effects between POMs and a well-defined framework derive specific function-driven architectures. Metal–organic frameworks (MOFs) are porous frameworks with designable topology and functionalities, and they are widely applied in the fields of gas adsorption and separation, catalysis, and sensors. − In contrast to conventional porous materials, the modulation of metal nodes of MOFs has great influence on both structural aesthetics and functional extension. − Lanthanide (Ln) ions possess high coordination number, abundant coordination configuration, and robust Lewis acidity, enabling Ln-MOFs with special capability in numerous catalytic systems …”

Section: Introductionmentioning

confidence: 99%

Lanthanide-Anderson Polyoxometalates Frameworks: Efficient Sulfide Photooxidation

Huang

Yang

2022

Inorg. Chem.

View full text Add to dashboard Cite

Three polyoxometalate-based metal–organic frameworks were synthesized by the thermal reaction of pyridyl-Anderson polyoxometalate linker and lanthanide ions. With the help of [Ru(bpy)3]2+ photosensitizer, these frameworks exhibited excellent photocatalytic sulfide oxidation performance with sulfoxide selectivity. The reactive oxygen species as well as the photooxidation mechanism were also explored.

show abstract

Section: Introductionmentioning

confidence: 99%

Lanthanide-Anderson Polyoxometalates Frameworks: Efficient Sulfide Photooxidation

Huang

Yang

2022

Inorg. Chem.

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…However, due to the chemical reactivity and short lifespan of ROS, as well as the complex relationship between ROS levels and disease, finely regulating ROS and controlling their levels within expected thresholds has become a major challenge. [8] Metal-organic network (MON) is a kind of highly regulated infinite network coordinated by organic ligands and metal ions, [9] which has attracted wide attention for its superior redox activity, porosity, large specific surface area, etc. In recent years, MON has been successively reported for use in the biomedical field.…”

Section: Introductionmentioning

confidence: 99%

Redox Modulatory Cu(II)‐Baicalein Microflowers Prepared in One Step Effectively Promote Therapeutic Angiogenesis in Diabetic Mice

Liu

Guo

et al. 2022

Adv Healthcare Materials

View full text Add to dashboard Cite

Reactive oxygen species (ROS) have been implicated in multiple cellular processes, and an imbalance in redox homeostasis gives rise to diseases, therefore, reestablishing redox homeostasis is a way to cure. Here, copper‐based metal‐organic networks (Cu‐MON) are generated by one‐step reaction using anti‐inflammatory and antioxidant baicalein as organic ligand and pro‐angiogenic copper as metal ions. Phosphate buffered saline is required for triggering Cu‐MON formation, and baicalein regulates the morphology and particle size of Cu‐MON. Cu‐MON are composed of Cu‐baicalein complexes (82.08 wt%) and Cu3(PO4)2·3H2O (17.92 wt%), thus exhibit a variable catalase‐like activity against different H2O2 levels due to the reversible change between Cu2+/Cu1+/Cu0 species. Intramuscular injection of Cu‐MON significantly increases blood flow of ischemic limb in diabetic mice, enhances the relative activities of redox‐related enzymes in ischemic muscle, thus effectively ameliorating the oxidative damage. Taken together, through moderate and dynamic “precise homeostasis regulation of cells,” Cu‐MON can be an efficient therapeutic strategy for peripheral arterial disease with diabetic complications.

show abstract

“…POMs have been widely studied in the fields of antitumor, antiviral, and antibacterial chemistry with the advantages of strong structural modifiability, low toxicity, few side effects, mature synthetic methods, and low cost. However, there are also some limitations of POMs, such as limited stimulus factors besides pH and GSH dose and a narrow pH range to induce POM quick response under TME and low targeting ability [ 18 , 19 , 20 ]. Molybdenum (Mo)-based POM clusters exhibit excellent photothermal conversion efficiency under near-infrared laser (NIR) [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

A Polyoxometalate-Encapsulated Metal–Organic Framework Nanoplatform for Synergistic Photothermal–Chemotherapy and Anti-Inflammation of Ovarian Cancer

Wang

Zhang

et al. 2022

Molecules

Self Cite

View full text Add to dashboard Cite

Photothermal therapy (PTT), as a noninvasive and local treatment, has emerged as a promising anti-tumor strategy with minimal damage to normal tissue under spatiotemporally controllable irradiation. However, the necrosis of cancer cells during PTT will induce an inflammatory reaction, which may motivate tumor regeneration and resistance to therapy. In this study, polyoxometalates and a chloroquine diphosphate (CQ) co-loaded metal–organic framework nanoplatform with hyaluronic acid coating was constructed for efficient ovarian cancer therapy and anti-inflammation. Our results demonstrated that this nanoplatform not only displayed considerable photothermal therapeutic capacity under 808 nm near-infrared laser, but also had an impressive anti-inflammatory capacity by scavenging reactive oxygen species in the tumor microenvironment. CQ with pH dependence was used for the deacidification of lysosomes and the inhibition of autophagy, cutting off a self-protection pathway induced by cell necrosis–autophagy, and achieving the synergistic treatment of tumors. Therefore, we combined the excellent properties of these materials to synthesize a nanoplatform and explored its therapeutic effects in various aspects. This work provides a promising novel prospect for PTT/anti-inflammation/anti-autophagy combinations for efficient ovarian cancer treatment through the fine tuning of material design.

show abstract

Polyoxometalate nanomaterials for enhanced reactive oxygen species theranostics

Cited by 51 publications

References 253 publications

Lanthanide-Anderson Polyoxometalates Frameworks: Efficient Sulfide Photooxidation

Lanthanide-Anderson Polyoxometalates Frameworks: Efficient Sulfide Photooxidation

Redox Modulatory Cu(II)‐Baicalein Microflowers Prepared in One Step Effectively Promote Therapeutic Angiogenesis in Diabetic Mice

A Polyoxometalate-Encapsulated Metal–Organic Framework Nanoplatform for Synergistic Photothermal–Chemotherapy and Anti-Inflammation of Ovarian Cancer

Contact Info

Product

Resources

About