Polyoxyethylene Lauryl Ether (Brij-35) and Poloxamer 407–Based Non-ionic Surfactant Vesicles for Dissolution Enhancement of Tacrolimus

Hanif, Razia; Khan, Muhammad Imran; Madni, Asadullah; Akhtar, Muhammad Furqan; Sohail, Muhammad; Saleem, Ammara; Rehman, Mubashar; Usmani, Soofia; Khan, Aslam; Masood, Afsheen

doi:10.1007/s12247-023-09737-2

J Pharm Innov

2023

DOI: 10.1007/s12247-023-09737-2

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Polyoxyethylene Lauryl Ether (Brij-35) and Poloxamer 407–Based Non-ionic Surfactant Vesicles for Dissolution Enhancement of Tacrolimus

Razia Hanif

Muhammad Imran Khan

Asadullah Madni

et al.

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2024

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Cited by 6 publications

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Thuy Trang Le,

Nguyen‐Huu,

Hai Nguyen

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ChemPlusChem

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Quercetin, a natural flavonoid with antioxidant, anti‐inflammatory, and anticancer properties, faces limitations in clinical application due to its poor solubility and bioavailability. This study presents a novel delivery system utilizing a combination of polyoxyethylene (100) stearyl ether and folic acid to enhance quercetin's effectiveness. We developed folate‐conjugated polyoxyethylene (100) stearyl ether‐coated liposomes (FA‐Brij‐LPs) to leverage the unique properties of polyoxyethylene (100) stearyl ether in conjunction with folic acid for targeted delivery. The FA‐Brij‐LPs were prepared using the thin‐film hydration method and characterized for their physicochemical properties, including size, zeta potential, and drug loading capacity. The optimized FA‐Brij‐LPs exhibited a mean particle size of 147.57 nm, a zeta potential of 32.20 mV, and a drug loading capacity of 9.33%. In vitro studies demonstrated sustained quercetin release and significantly enhanced cellular uptake compared to free quercetin. The Resazurin cell viability assay further revealed superior anticancer efficacy of FA‐Brij‐LPs. This innovative approach underscores the effectiveness of combining polyoxyethylene (100) stearyl ether with folic acid in enhancing quercetin delivery and its potential applications in cancer therapy.

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Advancing Liposomal Coating Approaches for Improved Anticancer Drug Delivery

Thuy Trang Le,

Nguyen‐Huu,

Hai Nguyen

et al. 2024

ChemPlusChem

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Carboxymethyl cellulose-based rotigotine nanocrystals-loaded hydrogel for increased transdermal delivery with alleviated skin irritation

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Polyoxyethylene Lauryl Ether (Brij-35) and Poloxamer 407–Based Non-ionic Surfactant Vesicles for Dissolution Enhancement of Tacrolimus

Cited by 6 publications

References 41 publications

Advancing Liposomal Coating Approaches for Improved Anticancer Drug Delivery

Advancing Liposomal Coating Approaches for Improved Anticancer Drug Delivery

Development and Characterization of Glimepiride-Loaded Polymeric Nanoparticles: Formulation Design and Evaluation

Carboxymethyl cellulose-based rotigotine nanocrystals-loaded hydrogel for increased transdermal delivery with alleviated skin irritation

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