Polypeptide Multilayer Films

Haynie, Donald T.; Zhang, Ling; Rudra, Jai S.; Zhao, Weiqiang; Ye, Zhong; Palath, Naveen

doi:10.1021/bm050525p

Cited by 104 publications

(134 citation statements)

References 209 publications

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“…Polypeptide nanofilms can be used as nano-scaled devices with defined structural properties or to customize the surfaces of other materials [117].…”

Section: Novel Systemsmentioning

confidence: 99%

Nanostructured materials for applications in drug delivery and tissue engineering

Goldberg

Langer

Jia

2007

Journal of Biomaterials Science, Polymer Edition

954

554

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Research in the areas of drug delivery and tissue engineering has witnessed tremendous progress in recent years due to their unlimited potential to improve human health. Meanwhile, the development of nanotechnology provides opportunities to characterize, manipulate and organize matter systematically at the nanometer scale. Biomaterials with nano-scale organizations have been used as controlled release reservoirs for drug delivery and artificial matrices for tissue engineering. Drug-delivery systems can be synthesized with controlled composition, shape, size and morphology. Their surface properties can be manipulated to increase solubility, immunocompatibility and cellular uptake. The limitations of current drug delivery systems include suboptimal bioavailability, limited effective targeting and potential cytotoxicity. Promising and versatile nano-scale drug-delivery systems include nanoparticles, nanocapsules, nanotubes, nanogels and dendrimers. They can be used to deliver both small-molecule drugs and various classes of biomacromolecules, such as peptides, proteins, plasmid DNA and synthetic oligodeoxynucleotides. Whereas traditional tissue-engineering scaffolds were based on hydrolytically degradable macroporous materials, current approaches emphasize the control over cell behaviors and tissue formation by nano-scale topography that closely mimics the natural extracellular matrix (ECM). The understanding that the natural ECM is a multifunctional nanocomposite motivated researchers to develop nanofibrous scaffolds through electrospinning or self-assembly. Nanocomposites containing nanocrystals have been shown to elicit active bone growth. Drug delivery and tissue engineering are closely related fields. In fact, tissue engineering can be viewed as a special case of drug delivery where the goal is to accomplish controlled delivery of mammalian cells. Controlled release of therapeutic factors in turn will enhance the efficacy of tissue engineering. From a materials point of view, both the drug-delivery vehicles and tissue-engineering scaffolds need to be biocompatible and biodegradable. The biological functions of encapsulated drugs and cells can be dramatically enhanced by designing biomaterials with controlled organizations at the nanometer scale. This review summarizes the most recent development in utilizing nanostructured materials for applications in drug delivery and tissue engineering.

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“…Polypeptide nanofilms can be used as nano-scaled devices with defined structural properties or to customize the surfaces of other materials [117].…”

Section: Novel Systemsmentioning

confidence: 99%

Nanostructured materials for applications in drug delivery and tissue engineering

Goldberg

Langer

Jia

2007

Journal of Biomaterials Science, Polymer Edition

954

554

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“…Ion pairing is largely athermal, driven by increased entropy from the release of salt counter ions originally neutralising the polyelectrolytes in solution [4]. In the last decade, LbL self-assembly technique was developed as a powerful method for the nano-and microencapsulation [4][5][6], where polyelectrolyte multilayer films were elaborated on various particles through alternating deposition of oppositely charged polyelectrolytes due to their electrostatic attraction accompanied with other associative interactions, such as hydrogenbonding, hydrophobic interaction, charge-transfer and so on [7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Microcapsules for controlled release fabricated via layer-by-layer self-assembly of polyelectrolytes

Wang

Sun

et al. 2008

Journal of Experimental Nanoscience

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Layer-by-layer (LbL) self-assembly of oppositely charged polyelectrolytes on different templates by alternating deposition is a versatile method enabling the construction of ultrathin multilayer films with tunable thickness, composition, and functions. The principal driving force for the LbL self-assembly is dominantly the electrostatic attraction between the polyelectrolyte components accompanied with other associative interactions, such as hydrogen-bonding, hydrophobic interaction, charge-transfer and so on. The LbL self-assembly technique has been a powerful tool for micro/nano-encapsulation. Our strategy is to fabricate the nano-multilayer wall for micro-and sub-microcapsules by the LbL of polyelectrolytes, particularly natural polymers chitosan (CHI) and alginate (ALG) for drug controlled release. Our recent work following this strategy is reviewed in the present article. After determining the charge density threshold for the LbL assembly, we immobilised enzymes of urease and superoxide dismutase on polystyrene nanoparticles through the LbL and found the decrease in enzyme bioactivity but an increase in their storage stability. We successfully fabricated the nanocapsules from natural polysaccharides of CHI and ALG multilayers by the LbL for drug release. The LbL self-assembly of CHI and ALG was used directly on indomethacin (IDM) microcrystals to reduce the release rate. We observed that increasing deposition temperature would produce a more perfect multilayer film with higher thickness and reduced the release rate efficiently. Water soluble protein insulin was spontaneously loaded into the LbL CHI/ALG microcapsules due to the electrostatic attraction and a two-temperature loading procedure was suggested to increase the loading capacity and to reduce the release rate. The LbL multilayers have been used to encapsulate the drug-loading microparticles made from solvent evaporation or adsorption with porous CaCO 3 microparticles to enhance the loading capacity and suppress the initial burst. Increasing the layer number, raising the deposition temperature, and cross-linking the neighboring layers were confirmed to slow down the enzymatic desorption of polyelectrolyte multilayer films and the release rate of encapsulated drug effectively.

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“…Although theoretically an indefinite number of polyelectrolyte layers can be applied on a substrate [15], a state of saturation can be reached in which no more polyelectrolytes will deposit [32]. There seems to be a positive association between molecular weight of the polyelectrolytes and the thickness and stability of the system [32,34], although the type of bonds that hold together the layers (when covalently bound) and their likelihood to undergo hydrolysis under different environmental conditions also dictates stability [32]. Layer-by-layer deposition can be used to prepare active packaging coatings by the incorporation of active agents either between layers or within the structure of an individual polyelectrolyte.…”

Section: Layer-by-layer Assemblymentioning

confidence: 99%

Active Packaging Coatings

et al. 2015

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Active food packaging involves the packaging of foods with materials that provide an enhanced functionality, such as antimicrobial, antioxidant or biocatalytic functions. This can be achieved through the incorporation of active compounds into the matrix of the commonly used packaging materials, or by the application of coatings with the corresponding functionality through surface modification. The latter option offers the advantage of preserving the packaging materials' bulk properties nearly intact. Herein, different coating technologies like embedding for controlled release, immobilization, layer-by-layer deposition, and photografting are explained and their potential application for active food packaging is explored and discussed.

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Polypeptide Multilayer Films

Cited by 104 publications

References 209 publications

Nanostructured materials for applications in drug delivery and tissue engineering

Nanostructured materials for applications in drug delivery and tissue engineering

Microcapsules for controlled release fabricated via layer-by-layer self-assembly of polyelectrolytes

Active Packaging Coatings

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