Polypeptide N-acetylgalactosaminyltransferase-Associated Phenotypes in Mammals

Kato, Kentaro; Hansen, Lars; Clausen, Henrik

doi:10.3390/molecules26185504

Cited by 25 publications

(18 citation statements)

References 134 publications

(161 reference statements)

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“…We identified genes associated with protein modification with increased expression in ethanol-fed non-irradiated mosquitoes relative to water-fed non-irradiated mosquitoes. One of these, polypeptide N-acetylgalactosaminyltransferase 5 belongs to a family of glycotransferases that participate in glycosylation of extracellular matrix (ECM) protein components ( Kato et al, 2021 ). The other gene, aminopeptidase N encodes a membrane-localized enzyme that removes amino acids from the N-terminal of proteins ( Turner, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Transcriptomics analysis of ethanol treatment of male Aedes aegypti reveals a small set of putative radioprotective genes

2023

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Introduction: Sterile Insect Technique (SIT) is based on releasing sterilized male insects into wild insect populations to compete for mating with wild females. Wild females mated with sterile males will produce inviable eggs, leading to a decline in population of that insect species. Sterilization with ionizing radiation (x-rays) is a commonly used mechanism for sterilization of males. Since irradiation can cause damage to both, somatic and germ cells, and can severely reduce the competitiveness of sterilized males relative to wild males, means to minimize the detrimental effects of radiation are required to produce sterile, competitive males for release. In an earlier study, we identified ethanol as a functional radioprotector in mosquitoes.Methods: Here, we used Illumina RNA-seq to profile changes in gene expression of male Aedes aegypti mosquitoes fed on 5% ethanol for 48 hours prior to receiving a sterilizing x-ray dose, compared to males fed on water prior to sterilization.Results: RNA-seq revealed a robust activation of DNA repair genes in both ethanol-fed and water-fed males after irradiation, but surprisingly few differences in gene expression between ethanol-fed and water-fed males regardless of radiation treatment.Discussion: While differences in gene expression due to ethanol exposure were minimal, we identified a small group of genes that may prime ethanol-fed mosquitoes for improved survivability in response to sterilizing radiation.

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Section: Discussionmentioning

confidence: 99%

Transcriptomics analysis of ethanol treatment of male Aedes aegypti reveals a small set of putative radioprotective genes

2023

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“…The GALNTL6 gene encodes the membrane-bound protein N-acetylgalactosaminyltransferase like 6, which has a significant role in the pathway of protein glycosylation (43,44). There are no previous reports of a role of this gene in the context of diabetes and its vascular complications.…”

Section: Discussionmentioning

confidence: 99%

Genome-wide association study of longitudinal urinary albumin excretion in patients with type 1 diabetes

Hutchinson

Chen

Önengüt-Gümüşcü

et al. 2022

Preprint

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Identifying genetic determinants for longitudinal changes in albumin excretion in individuals with type 1 diabetes may help identify those that are predisposed to renal, retinal and cardiovascular complications. Most studies have focussed on genetic predisposition to diabetic kidney disease and used cross-sectional measurements of urinary albumin excretion, but with limited success. Here, we utilise the wealth of longitudinal data and bio-samples collected from cohorts of childhood-onset type 1 diabetes followed over the last 30 years to describe a novel trajectory phenotype quantifying urinary albumin excretion changes during childhood and adolescence. We conducted a genome-wide association study and fine-mapping analysis for albumin excretion in 1584 individuals, finding one signal for cross-sectional albumin excretion close to GALNTL6 (rs150766792), which validated in a previous independent study, and a novel genome-wide significant signal for albumin excretion trajectory in the CDH18 gene region (rs145715205). Our trajectory phenotype quantifies albumin progression and offers a complementary measure to an albumin excretion phenotype based on a single measurement (i.e. most recent data collection) or an average of repeated measurements in longitudinal studies. It can be used to identify genetic or other risk factors which predict better or worse prognosis, thus facilitating the development of new preventive and therapeutic approaches.

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“…According to genome-wide association studies (GWAS), a subset of genes encoding O-glycosylation enzymes have been found to be highly associated with ASD and schizophrenia [ 51 , 105 ]. For example, GALNT9 , which is mainly expressed in the brain, was reported to be associated with ASD [ 51 , 105 , 106 ]. In clinical studies, microdeletions of chromosome 2q have also been reported in ASD individuals with developmental delay, language delay, communication disorders, and social anxiety [ 107 , 108 ].…”

Section: O-glycosylationmentioning

confidence: 99%

Glycosylation and behavioral symptoms in neurological disorders

2023

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Glycosylation, the addition of glycans or carbohydrates to proteins, lipids, or other glycans, is a complex post-translational modification that plays a crucial role in cellular function. It is estimated that at least half of all mammalian proteins undergo glycosylation, underscoring its importance in the functioning of cells. This is reflected in the fact that a significant portion of the human genome, around 2%, is devoted to encoding enzymes involved in glycosylation. Changes in glycosylation have been linked to various neurological disorders, including Alzheimer’s disease, Parkinson’s disease, autism spectrum disorder, and schizophrenia. Despite its widespread occurrence, the role of glycosylation in the central nervous system remains largely unknown, particularly with regard to its impact on behavioral abnormalities in brain diseases. This review focuses on examining the role of three types of glycosylation: N-glycosylation, O-glycosylation, and O-GlcNAcylation, in the manifestation of behavioral and neurological symptoms in neurodevelopmental, neurodegenerative, and neuropsychiatric disorders.

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Polypeptide N-acetylgalactosaminyltransferase-Associated Phenotypes in Mammals

Cited by 25 publications

References 134 publications

Transcriptomics analysis of ethanol treatment of male Aedes aegypti reveals a small set of putative radioprotective genes

Transcriptomics analysis of ethanol treatment of male Aedes aegypti reveals a small set of putative radioprotective genes

Genome-wide association study of longitudinal urinary albumin excretion in patients with type 1 diabetes

Glycosylation and behavioral symptoms in neurological disorders

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