Polypharmacy among people living with type 2 diabetes mellitus in rural communes in Vietnam

Abstract

Objectives People with diabetes are at high risk of polypharmacy owing to complex treatment of diabetes and comorbidities. Polypharmacy is associated with increased risk of adverse reactions and decreased compliance. Therefore, the objectives of this study were to assess polypharmacy in people with type 2 diabetes (T2D) and associated diabetes-related factors in rural areas in Vietnam. Method People with T2D (n = 806) who had received treatment for diabetes at a district hospital were invited to participate in a questionnaire-based cross-sectional survey. Polypharmacy was defined as ≥5 types of medicine and assessed as a) prescription medicine and non-prescription/over the counter (OTC) medicine and b) prescription medicine and non-prescription/OTC, herbal and traditional medicine, and dietary supplement. Multiple logistic regression was used to investigate the association between polypharmacy and diabetes specific factors: duration, comorbidities and diabetes-related distress. Results Of the people with T2D, 7.8% had a medicine use corresponding to polypharmacy (prescription medicine and non-prescription/OTC), and 40.8% when herbal and traditional medicine, and dietary supplement were included. Mean number of medicine intake (all types of medicines and supplements) were 3.8±1.5. The odd ratios (ORs) of polypharmacy (medicine and supplements) increased with diabetes duration (<1–5 years OR = 1.66; 95%CI: 1.09–2.53 and >5 years OR = 1.74; 95%CI: 1.14–2.64 as compared to ≤1-year duration of diabetes), number of comorbidities (1–2 comorbidities: OR = 2.0; 95%CI: 1.18–3.42; ≥3 comorbidities: OR = 2.63;95%CI: 1.50–4.61 as compared to no comorbidities), and suffering from diabetes-related distress (OR = 1.49; 95%CI: 1.11–2.01) as compared to those without distress. Conclusions In rural northern Vietnam, persons with longer duration of T2D, higher number of comorbidities and diabetes-related stress have higher odds of having a medicine use corresponding to polypharmacy. A high proportion of people with T2D supplement their prescription, non-prescription/OTC medicine with herbal and traditional medicine and dietary supplements.

Potential for Prebiotic Stabilized Cornus mas L. Lyophilized Extract in the Prophylaxis of Diabetes Mellitus in Streptozotocin Diabetic Rats

“…Raw materials of plant origin are increasingly used to treat and support diseases of civilization, particularly diabetes mellitus (DM) [ 1 , 2 ]. Due to the complexity of the causes and effects of DM, most patients, in addition to polytherapy, also use dietary supplements to support glycemic control [ 3 , 4 ]. Plant raw materials are a rich source of active substances with high therapeutic potential.…”

Diabetes-related Distress and the Association to Hypertension and Cardiovascular Disease Among Individuals Living with Type 2 Diabetes in Rural areas in Vietnam

“…Besides the psychological impact of DRD, studies from high-income countries report that DRD influences glycaemic control and self-care: people with DRD had higher blood levels of triglycerides and higher BMI [5,10]. Additionally, two more recent studies based on analyses of data from the same population in Vietnam as used in the present study, DRD was associated with the occurrence of polypharmacy and unmet needs for social support [8,11].…”

“…Additionally, two more recent studies based on analyses of data from the same population in Vietnam as used in the present study, DRD was associated with the occurrence of polypharmacy and unmet needs for social support[8, 11].…”

Analysis of drug use in young-onset and late-onset patients with type 2 diabetes mellitus in southwestern China based on the YiduCloud database.

“…Older age group tended to receive more different combined drug treatments. This also consists with the study [27][28][29] conducted to analyze related factors polypharmacy. We estimate that LOD are more likely to have other complications because of the worsen physiological conditions and their own blood sugar conditions are more complex.…”