Polypharmacy and Lack of Joy Are Related to Physical Frailty among Northern Japanese Community-Dwellers from the ORANGE Cohort Study

Kume, Yu; Takahashi, Tomoko; Itakura, Yuki; Lee, Sangyoon; Makizako, Hyuma; Ono, Tsuyosi; Shimada, Hiroyuki; Ota, Hidetaka

doi:10.1159/000511986

Cited by 8 publications

(9 citation statements)

References 37 publications

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“…All of these consequences tend to promote or heighten frailty. In line with the above information, there are certain studies that conclude that the lack of joy and the presence of a negative attitude towards ageing can function as risk factors for frailty [43,44]. Our findings show that the presence of a psychopathology doubles the odds of an older person presenting pre-frailty.…”

Section: Discussionsupporting

confidence: 89%

Assessing Prevalence and Factors Related to Frailty in Community-Dwelling Older Adults: A Multinomial Logistic Analysis

Blanco-Reina

Aguilar-Cano

García-Merino³

et al. 2021

JCM

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Frailty is an age-related clinical condition that typically involves a deterioration in the physiological capacity of various organ systems and heightens the patient’s susceptibility to stressors. For this reason, one of the main research goals currently being addressed is that of characterising the impact of frailty in different settings. The main aim of this study is to determine the prevalence of Fried’s frailty phenotype among community-dwelling older people and to analyse the factors associated with frailty. In this research study, 582 persons aged 65 years or more participated in this cross-sectional study that was conducted at primary healthcare centres in Málaga, Spain. Sociodemographic, clinical, functional and comprehensive drug therapy data were compiled. The relationship between the independent variables and the different states of frailty was analysed by using a multinomial logistic regression model. Frailty was present in 24.1% of the study sample (95% CI = 20.7–27.6) of whom 54.3% were found to be pre-frail and 21.6% were non-frail. The study variable most strongly associated with frailty was the female gender (OR = 20.54, 95% CI = 9.10–46.3). Other factors found to be associated with the state of frailty included age, dependence for the instrumental activities of daily living (IADL), polymedication, osteoarticular pathology and psychopathology. This study confirms the high prevalence of frailty among community-dwelling older people. Frailty may be associated with many factors. Some of these associated factors may be preventable or modifiable and, thus, provide clinically relevant targets for intervention. This is particularly the case for depressive symptoms, the clinical control of osteoarthritis and the use of polypharmacy.

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Section: Discussionsupporting

confidence: 89%

Assessing Prevalence and Factors Related to Frailty in Community-Dwelling Older Adults: A Multinomial Logistic Analysis

Blanco-Reina

Aguilar-Cano

García-Merino³

et al. 2021

JCM

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“…The NCGG-FAT has been reported to be highly reliable and valid compared to traditional neurocognitive scales [ 23 ]. The NCGG-FAT has been used in previous studies with community-dwelling older adults [ 8 , 25 , 26 , 27 ]. Physical frailty was defined using the five components suggested by Fried: slowness, weakness, exhaustion, low physical activity and weight loss [ 4 ].…”

Section: Methodsmentioning

confidence: 99%

Social Frailty and Meaningful Activities among Community-Dwelling Older Adults with Heart Disease

Akasaki¹,

Tabira

Maruta

et al. 2022

IJERPH

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Patients with heart disease are more likely to experience social frailty due to physical inactivity, which may affect meaningful activities such as hobbies. This study aimed to investigate (1) the association between heart disease and social frailty in community-dwelling older adults and (2) the characteristics of meaningful activities in community-dwelling older adults with heart disease. Data from 630 older adults who participated in a community-based health survey were obtained, including clinical history, meaningful activities, social frailty and psychosomatic functions. Participants were divided into two groups: those with heart disease (n = 79) and those without (n = 551), and comparisons were made. Social frailty was observed in 23.7% of participants with heart disease, and logistic regression revealed significant associations with heart disease and social frailty after adjusting for potential covariates (OR, 1.97; 95% CI, 1.06 3.67; p = 0.032). Participants with heart disease did not differ significantly in terms of satisfaction or performance; their frequency of engagement in meaningful activities was significantly lower than without heart disease (p = 0.041). These results suggest that heart disease and social frailty are associated in community-dwelling older adults, and that this demographic is inclined to engage in meaningful activities less frequently.

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“…However, some evidence of a relationship with depression has also been observed, but this association appears to be weaker and is less commonly reported [45][46][47]. An association has also been reported between mental pathology and frailty [48,49]. It has been observed that persons with a psychopathology tend to be less physically active, to have a less active social life, and to consume a less healthy diet, and that any or all of these factors could be related to a loss of strength and muscle mass.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Clinical Conditions Related to Sarcopaenia among Older Persons Living in the Community

Blanco-Reina

Ocaña-Riola

Ariza-Zafra

et al. 2022

JCM

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(1) Background: In health care and in society at large, sarcopaenia is a disorder of major importance that can lead to disability and other negative health-related events. Our study aim is to determine the prevalence of sarcopaenia among older people attended in primary care and to analyse the factors associated with this age-related clinical condition; (2) Methods: A multicentre cross-sectional study was conducted of 333 community-dwelling Spanish adults aged 65 years or more. Sociodemographic, clinical, functional, anthropometric, and pharmacological data were collected. Sarcopaenia was defined following European Working Group on Sarcopaenia in Older People (EWGSOP) criteria; (3) Results: Sarcopaenia was present in 20.4% of the study sample, and to a severe degree in 6%. The intensity of the association between sarcopaenia and frailty was weak-moderate (Cramer V = 0.45). According to the multinomial logistic regression model performed, sarcopaenia was positively associated with age and with the presence of psychopathology (OR = 2.72; 95% CI = 1.30–5.70) and was inversely correlated with body mass index (OR = 0.73, 95% CI = 0.67–0.80; (4) Conclusions: Sarcopaenia commonly affects community-dwelling older persons and may be associated with age, body mass index, and psychopathology. The latter factor may be modifiable or treatable and is therefore a possible target for intervention.

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Polypharmacy and Lack of Joy Are Related to Physical Frailty among Northern Japanese Community-Dwellers from the ORANGE Cohort Study

Cited by 8 publications

References 37 publications

Assessing Prevalence and Factors Related to Frailty in Community-Dwelling Older Adults: A Multinomial Logistic Analysis

Assessing Prevalence and Factors Related to Frailty in Community-Dwelling Older Adults: A Multinomial Logistic Analysis

Social Frailty and Meaningful Activities among Community-Dwelling Older Adults with Heart Disease

Prevalence and Clinical Conditions Related to Sarcopaenia among Older Persons Living in the Community

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