Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes

Gnjidic, Danijela; Hilmer, Sarah N.; Blyth, Fiona; Naganathan, Vasi; Waite, Louise M.; Seibel, Markus J.; McLachlan, Andrew J.; Cumming, Robert G.; Handelsman, David J.; Couteur, David G. Le

doi:10.1016/j.jclinepi.2012.02.018

Cited by 970 publications

(795 citation statements)

References 39 publications

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“…Educational level was categorized as low (obligatory school or apprenticeship), medium (high school), or high (university degree). Height and weight were assessed with the participants in light clothes and without shoes using a Seca® scale; body mass index (BMI) was categorized as normal (18.5< BMI <25 kg/m 2 ), overweight (25≤ BMI <30 kg/m 2 ) and obese (≥30 kg/m 2 ). As the number of underweight (BMI≤ 18.5 kg/m 2 ) participants was small, they were included in the normal weight group.…”

Section: Lifestyle Clinical and Biological Parametersmentioning

confidence: 99%

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Determinants of change in polypharmacy status in Switzerland: the population-based CoLaus study

Abolhassani

Castioni

Marques‐Vidal

et al. 2017

Eur J Clin Pharmacol

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Objectives: To assess the prevalence, the change and the determinants of change in polypharmacy in a population-based sample.Methods: Baseline (2003-06) and follow-up (2009-12) data from 4679 participants aged between 35 and 75 years (53.5% women, mean age 52.6 ± 10.6 years) from the population of Lausanne, Switzerland.Polypharmacy was defined by the regular use of ≥5 drugs. Four categories of change were defined: never (no polypharmacy at baseline and follow-up), initiating (no polypharmacy at baseline but at follow-up), maintaining or quitting.Results: Polypharmacy increased from 7.7% at baseline to 15.3% at follow-up. Cardiovascular drugs were the most prescribed medicines at baseline and follow up. Gender, age, obesity, smoking, previously diagnosed hypertension or diabetes or dyslipidemia were significantly and independently associated with initiating and maintaining polypharmacy. Conclusion:In a population-based sample, prevalence of polypharmacy doubled over a 5.6 year period.The main determinants of initiating polypharmacy were age, overweight and obesity, smoking status and previous diagnosed cardiovascular risk factors. Abstract word count: 159

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Section: Lifestyle Clinical and Biological Parametersmentioning

confidence: 99%

“…[1] Subsequently, prevalence of polypharmacy, referred as the simultaneous intake of five or more medications, has been increasing [2] not only among the elderly but also in other ages. [3] Polypharmacy is driven by the increase in age and multimorbidity.…”

Section: Introductionmentioning

confidence: 99%

Determinants of change in polypharmacy status in Switzerland: the population-based CoLaus study

Abolhassani

Castioni

Marques‐Vidal

et al. 2017

Eur J Clin Pharmacol

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“…2,8 In Sweden more than 40% of the population aged 77+ years use more than 5 drugs concurrently. 9 Concurrent use of many drugs (polypharmacy) 10 is common in older adults 11 and is a risk factor for adverse drug reactions and drug-drug interactions (DDIs). 8,[11][12][13] In addition, due to altered pharmacokinetics and pharmacodynamics in old age, elderly patients are particularly sensitive to drugs and at increased risk of adverse drug reactions.…”

Section: Introductionmentioning

confidence: 99%

Time trends in 20 years of medication use in older adults: Findings from three elderly cohorts in Stockholm, Sweden

Craftman

Johnell

Fastbom

et al. 2016

Archives of Gerontology and Geriatrics

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“…18 There were no differences between the groups with or without an alternative feeding route in relation to the amount of medication prescribed (p=0.057). The classes of medications prescribed the most were antihypertensive drugs (53.2%), antipsychotics (33.9%), antiplatelet agents (29%), benzodiazepines (27.4%), and antidepressants (19.4%).…”

Section: Methodsmentioning

confidence: 86%

Advanced dementia in a sample of Brazilian elderly: Sociodemographic and morbidity analysis

Cintra

Rezende

Torres

2016

Rev. Assoc. Med. Bras.

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Summary Introduction: To investigate the sociodemographic and morbidity profile of advanced dementia patients and sociodemographic data of their primary caregivers. Method: Data was obtained from 67 elderly recruited for an observational prospective study, through interviews performed with primary caregivers. For statistical analysis, the Statistical Package for the Social Sciences (SPSS(r)) for Windowsr, version 19.0. was employed. Results: Advanced dementia patients were mostly women, widows, and non-institutionalized, with low-income. An elevated rate of stroke, sarcopenia, and pressure ulcers in this population is noted. Caregivers were mostly women, married, children of the studied patients, and unemployed. Only one third of caregivers were hired for the task. Conclusion: Patients with advanced dementia present a high morbidity profile, low income, and depend on the care given by family members, mostly unemployed daughters.

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Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes

Cited by 970 publications

References 39 publications

Determinants of change in polypharmacy status in Switzerland: the population-based CoLaus study

Determinants of change in polypharmacy status in Switzerland: the population-based CoLaus study

Time trends in 20 years of medication use in older adults: Findings from three elderly cohorts in Stockholm, Sweden

Advanced dementia in a sample of Brazilian elderly: Sociodemographic and morbidity analysis

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