Polypharmacy in Geriatric Patients

LeSage, Joan

doi:10.1016/s0029-6465(22)00247-x

Cited by 24 publications

(1 citation statement)

References 49 publications

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“…While this might be expected due to the presence of multiple co-morbidities, and can be rationalised to a certain extent, it can lead to confusion with treatment regimes, non-adherence and an increased risk of adverse events due to drug interactions. 29 In particular, it is important to avoid prescribing medications to treat the side effects of other medications, such as giving a diuretic to treat ankle oedema secondary to a calcium channel blocker. A better approach is to change the primary medication causing the side effect.…”

Section: Polypharmacy and Multiple Co-morbiditiesmentioning

confidence: 99%

Hypertension in Octogenarians – Treatment Strategies and Challenges

Mackenzie¹,

MacDonald²

2011

European Cardiology Review

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The demographics of westernised countries are changing and older people now represent a larger and increasing proportion of the overall population. Since age is a potent risk factor for hypertension, this has resulted in many more octogenarians and older who require antihypertensive therapy. In this article we discuss the evidence base for drug treatment of octogenarians and older. We discuss the choice of drug therapies and outline some of the features that make treatment of such patients a challenge, in particular drug intolerance. We discuss the role of prescribing multiple low-dose therapies to increase the benefits while mitigating the adverse effects. We also discuss the thorny issues of polypharmacy and resistant hypertension and finally we discuss the role of ambulatory blood pressure monitoring as a tool for avoiding blood pressure misclassification in older subjects.

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Section: Polypharmacy and Multiple Co-morbiditiesmentioning

confidence: 99%