Polyphenol‐Based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment

Zhang, Zhan; Sang, Wei; Xie, Lisi; Li, Wenxi; Li, Bei; Li, Jie; Tian, Hao; Yuan, Zhen; Zhao, Qi; Dai, Yunlu

doi:10.1002/anie.202013406

Cited by 123 publications

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“…Understanding these applications will help us to learn more about the properties and functions of polyphenols, and to expand the horizons for designing more polyphenol-based nanosystems. [222] Copyright 2020, Wiley-VCH.…”

Section: Other Biomedical Applicationsmentioning

confidence: 99%

“…On the other hand, Zhang et al synthesized an MPN-based nanocomplex (termed PFG) via the metal-polyphenol coordination between a PEG-chlorin e6 (Ce6) polyphenol derivative, Fe 2+ , and gossypol (a natural polyphenol). [222] The PFGs could induce immunogenic cell death (ICD) in the tumor area via PDT and chemotherapy upon 660 nm laser irradiation after intravenous injection (Figure 17). Furthermore, anti-programmed cell death ligand-1 (PD-L1) antibodies were used to reinforce the PFGbased cancer immune therapy.…”

Section: Other Biomedical Applicationsmentioning

confidence: 99%

“…DC: dendritic cell, CTL: cytotoxic T lymphocyte, PD-1: programmed cell death-1, DAMPs: damage-associated molecular patterns, TAAs: tumor-associated antigens. Reproduced with permission [222]. Copyright 2020, Wiley-VCH.…”

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Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

et al. 2021

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Polyphenols, the phenolic hydroxyl group-containing organic molecules, are widely found in natural plants and have shown beneficial effects on human health. Recently, polyphenol-containing nanoparticles have attracted extensive research attention due to their antioxidation property, anticancer activity, and universal adherent affinity, and thus have shown great promise in the preparation, stabilization, and modification of multifunctional nanoassemblies for bioimaging, therapeutic delivery, and other biomedical applications. Additionally, the metal−polyphenol networks, formed by the coordination interactions between polyphenols and metal ions, have been used to prepare an important class of polyphenol-containing nanoparticles for surface modification, bioimaging, drug delivery, and disease treatments. By focusing on the interactions between polyphenols and different materials (e.g., metal ions, inorganic materials, polymers, proteins, and nucleic acids), a comprehensive review on the synthesis and properties of the polyphenol-containing nanoparticles is provided. Moreover, the remarkable versatility of polyphenol-containing nanoparticles in different biomedical applications, including biodetection, multimodal bioimaging, protein and gene delivery, bone repair, antibiosis, and cancer theranostics is also demonstrated. Finally, the challenges faced by future research regarding the polyphenol-containing nanoparticles are discussed.

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Section: Other Biomedical Applicationsmentioning

confidence: 99%

Section: Other Biomedical Applicationsmentioning

confidence: 99%

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Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

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“…A MPNbased combination therapy was reported by our group, in which the Chlorin e6 was linked to a PEG-polyphenol, serving as a photosensitizer and a self-carrier at the same time. [17] Besides, a natural polyphenol, gossypol, and ferrous ions were used for the fabrication of the final PEG-Ce6-Fe 2+ -gossypol MPNs (Figure 19A). Upon 660 nm laser irradiation, these MPNs can cause significant cancer cell DNA damage and immunogenic cancer cell death (Figure 19B), which may further induce the maturation of dendritic cells and the activation of immune system (Figure 19C).…”

Section: Phototherapymentioning

confidence: 99%

Recent Advances in Metal‐Phenolic Networks for Cancer Theranostics

Zhang

Xie

et al. 2021

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can specially accumulate in tumor sites due to the dysfunctional vasculatures, which is defined as enhanced permeation and retention (EPR) effect. [3] Beyond the physical features, nanomaterials constructing the NPs themselves can also bring in some novel properties such as new therapeutic mechanisms, environment-responsive drug release, stealth and targeting property, and ligand-based immune activation, etc. [4] To endow the NPs with more functions to achieve the enhancement of therapeutic efficacy and precision medicine, much efforts have been made in the field of nanomaterial engineering.Polyphenols, which have been demonstrated to have the effect of anti-tumor, anti-oxidation, anti-radiation, and antithrombosis, exist widely in natural plants such as tea, fruits, vegetables, and cereals. [5] A number of polyphenols have been FDAapproved for food preparation and human health. Polyphenols can be divided into naturally occurring polyphenols and artificial polyphenol derivatives. As the name shows, there remain abundant phenolic moieties that can chelate metal ions in polyphenols. [6] Metal ions play a key role in the field of biomedicine and chemical catalysis. The existence of multivalent metal ions can induce the crosslinking of polyphenols, thereby leading to the self-assembly of metal-phenolic networks (MPNs). The plentiful types of polyphenols and metals endow the MPNs with diverse properties and functions (Figure 1). MPNs, as promising carriers for drug delivery, are fabricated upon the coordination between phenolic ligands and metal ions, without any help of heat, electricity, or other special solvents. Because of the excellent adhesion capability of polyphenols, MPNs can be coated on various substrates or interfaces (serving as templates) regardless of the structures and shapes. The MPNs nanocoating may confer special and desired properties to the original substrates. Meanwhile, in some designs, the templates can be easily removed, thereby leading to the formation of MPN capsules. [7] MPNs can also self-assemble into spherical NPs without a template. [8] By varying the types of polyphenols, metal ions, or the encapsulated cargos, MPNs can be endowed with various functions. [6a,7b,9] For example, gossypol, a type of polyphenol extracted from cotton seeds, can act as both a selfcarrier and a chemical drug. [4b] Metal ions existed in MPNs not only help to crosslink polyphenols, but also achieve other functions such as biomedical imaging, changing of signaling pathway, and treatment. [6a,10] For example, gadolinium ions (Gd 3+ ) were assembled into MPNs to realize the function of T 1 -weighted Nanomedicine integrates different functional materials to realize the customization of carriers, aiming at increasing the cancer therapeutic efficacy and reducing the off-target toxicity. However, efforts on developing new drug carriers that combine precise diagnosis and accurate treatment have met challenges of uneasy synthesis, poor stability, difficult metabolism, and high cytotoxicity. Metal-phenolic networks...

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“…By introducing phosphotungstate and cysteine, CDT effects were ensured at both neutral and acidic pH, thus circumventing the limited CDT effect in neutral pH. [ 46 ] Other studies on Fe‐coordinated supramolecular nanoconstructs can be divided into two categories: Fe‐coordinated natural products [ 45 , 52 , 53 , 54 , 56 , 58 , 127 ] and nanoscale polymer systems. [ 47 , 55 , 57 , 128 ] All these works demonstrated the advantages and immense potential of Fe 2+/3+ coordination in constructing multifunctional supramolecular nanodrugs for cancer theranostic applications.…”

Section: Metal‐coordinated Supramolecular Self‐assemblies For Cancer Theranosticsmentioning

confidence: 99%

Metal‐Coordinated Supramolecular Self‐Assemblies for Cancer Theranostics

Wang

Jin

et al. 2021

Advanced Science

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Metal‐coordinated supramolecular nanoassemblies have recently attracted extensive attention as materials for cancer theranostics. Owing to their unique physicochemical properties, metal‐coordinated supramolecular self‐assemblies can bridge the boundary between traditional inorganic and organic materials. By tailoring the structural components of the metal ions and binding ligands, numerous multifunctional theranostic nanomedicines can be constructed. Metal‐coordinated supramolecular nanoassemblies can modulate the tumor microenvironment (TME), thus facilitating the development of TME‐responsive nanomedicines. More importantly, TME‐responsive organic–inorganic hybrid nanomaterials can be constructed in vivo by exploiting the metal‐coordinated self‐assembly of a variety of functional ligands, which is a promising strategy for enhancing the tumor accumulation of theranostic molecules. In this review, recent advancements in the design and fabrication of metal‐coordinated supramolecular nanomedicines for cancer theranostics are highlighted. These supramolecular compounds are classified according to the order in which the coordinated metal ions appear in the periodic table. Furthermore, the prospects and challenges of metal‐coordinated supramolecular self‐assemblies for both technical advances and clinical translation are discussed. In particular, the superiority of TME‐responsive nanomedicines for in vivo coordinated self‐assembly is elaborated, with an emphasis on strategies that enhance the accumulation of functional components in tumors for an ideal theranostic outcome.

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Polyphenol‐Based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment

Cited by 123 publications

References 46 publications

Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

Recent Advances in Metal‐Phenolic Networks for Cancer Theranostics

Metal‐Coordinated Supramolecular Self‐Assemblies for Cancer Theranostics

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