Polyphenol containing
            <i>Sargassum horneri</i>
            attenuated Th2 differentiation in splenocytes of ovalbumin-sensitised mice: involvement of the transcription factors GATA3/STAT5/NLRP3 in Th2 polarization

Herath, Kalahe Hewage Iresha Nadeeka Madushani; Cho, Jin-Hee; Kim, Hyo Jin; Dinh, Duong Thi Thuy; Kim, Hyunsoo; Ahn, Ginnae; Jeon, You‐Jin; Jee, Youngheun

doi:10.1080/13880209.2021.1992451

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…The S. horneri component has been shown to exert suppressive effects on the inflammatory state of various cell types, including macrophages, retinal cells, and dermal fibroblasts [39][40][41][42][43][44][45][46][47][48][49][50][51]. In this mini review, the author has focused on inflammatory macrophages.…”

Section: Suppressive Effects Of the S Horneri Component On The Inflam...mentioning

confidence: 99%

The Marine Alga Sargassum horneri Is a Functional Food with High Bioactivity

Yamaguchi

2024

Nutraceuticals

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Functional food factors can play a preventive and therapeutic role in several human diseases. The marine alga Sargassum horneri (S. horneri) has restorative effects in several types of metabolic disorders, including osteoporosis, diabetes, inflammatory conditions, and cancer cell growth. Osteoporosis is widely recognized as a major public health problem. Bone loss associated with ageing and diabetic states was prevented through the intake of bioactive compounds from S. horneri water extract in vivo by stimulating osteoblastic bone formation and inhibiting osteoclastic bone resorption in vitro. The intake of S. horneri water extract was found to have preventive effects on diabetic findings with an increase in serum glucose and lipid components. Furthermore, the S. horneri component has been shown to suppress adipogenesis from rat bone marrow cells and inflammatory conditions in vitro. Notably, the growth of bone metastatic human breast cancer MDA-MB-231 cells, which induce bone loss with osteolytic effects, was suppressed through culturing with the S. horneri water extract component in vitro. The S. horneri component, which has a molecular weight of less than 1000, was found to suppress the activation of NF-κB signaling by tumor necrosis factor-α, a cytokine associated with inflammation, in osteoblastic cells and macrophage RAW264.7 cells in vitro, suggesting a molecular mechanism. The bioactive component of S. horneri may play a multifunctional role in the prevention and treatment of metabolic disorders. This review outlines the advanced knowledge of the biological activity of the aqueous extract components of S. horneri and discusses the development of health supplements using this material.

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Section: Suppressive Effects Of the S Horneri Component On The Inflam...mentioning

confidence: 99%

The Marine Alga Sargassum horneri Is a Functional Food with High Bioactivity

Yamaguchi

2024

Nutraceuticals

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“…Beberapa penelitian menunjukkan bahwa senyawa fitokimia dalam makroalga dapat berperan sebagai imunostimulan pada ikan dan udang dalam akuakultur. Beberapa studi menjelaskan bahwa ekstrak alga cokelat, Sargassum horneri, mengandung senyawa fitokimia seperti flavonoid dan tannin yang memiliki efek stimulasi pada respons imun ikan laut (Herath et al, 2021;Kim et al, 2022;Liyanage et al, 2022). Penelitian sejenis juga menemukan bahwa pemberian ekstrak S. horneri pada pakan ikan mampu meningkatkan aktivitas enzim superoksida dismutase dan glutation peroksidase, yang merupakan indikator penting dari respons imun dan antioksidan pada ikan (Brontowiyono et al, 2022;Shi et al, 2021).…”

Section: B Alga Laut Sebagai Imunostimulanunclassified

Peluang dan Tantangan Pengembangan Bioteknologi Melalui Pemanfaatan Makroalga Laut sebagai Imunostimulan dalam Mendukung Akuakultur Berkelanjutan

R Adharyan Islamy

2023

Pengelolaan Sumber Daya Perikanan Laut Berkelanjutan

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Produk perikanan makin meningkat dari tahun ke tahun. Namun, seperti kegiatan pertanian lainnya, akuakultur juga dihadapkan pada berbagai tantangan, termasuk munculnya penyakit dan stres yang dapat menurunkan kualitas dan kuantitas produksi (Walker & Winton, 2010). Sebagai respons, beberapa pembudi daya mungkin telah mengandalkan penggunaan bahan kimia seperti antibiotik, hormon pertumbuhan, dan pestisida untuk meningkatkan produktivitas serta mengendalikan penyakit pada ikan budi daya. Bahan-bahan yang

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Suppression of adipogenesis by Au nanostructures-conjugated Sargassum seaweed extracts in 3 T3-L1 adipocytes

Park

Kim

et al. 2022

Arabian Journal of Chemistry

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Polyphenol containing Sargassum horneri attenuated Th2 differentiation in splenocytes of ovalbumin-sensitised mice: involvement of the transcription factors GATA3/STAT5/NLRP3 in Th2 polarization

Cited by 4 publications

References 36 publications

The Marine Alga Sargassum horneri Is a Functional Food with High Bioactivity

The Marine Alga Sargassum horneri Is a Functional Food with High Bioactivity

Peluang dan Tantangan Pengembangan Bioteknologi Melalui Pemanfaatan Makroalga Laut sebagai Imunostimulan dalam Mendukung Akuakultur Berkelanjutan

Suppression of adipogenesis by Au nanostructures-conjugated Sargassum seaweed extracts in 3 T3-L1 adipocytes

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