Polyphenol extract of Phyllanthus emblica (PEEP) induces inhibition of cell proliferation and triggers apoptosis in cervical cancer cells

Zhu, Xinxian; Wang, Jianjun; Ou, Yang; Wang, Han; Li, Huaifang

doi:10.1186/2047-783x-18-46

Cited by 40 publications

(21 citation statements)

References 17 publications

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“…Katrin Sak Tudoran et al, 2012;Kitdamrongtham et al, 2013;Zhu et al, 2013). Thus, a woman`s risk of developing cervical cancer by 65 years of age has been estimated to range from 0.69% in developed countries to 1.38% in developing countries (Muthusami et al, 2013).…”

Section: Characteristic Features Of Cytotoxic Activity Of Flavonoids mentioning

confidence: 99%

Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells

Sak¹

2014

Asian Pacific Journal of Cancer Prevention

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Cervical cancer is the most common gynecologic malignancy worldwide and development of new therapeutic strategies and anticancer agents is an urgent priority. Plants have remained an important source in the search for novel cytotoxic compounds and several polyphenolic flavonoids possess antitumor properties. In this review article, data about potential anticarcinogenic activity of common natural flavonoids on various human cervical cancer cell lines are compiled and analyzed showing perspectives for the use of these secondary metabolites in the treatment of cervical carcinoma as well as in the development of novel chemotherapeutic drugs. Such anticancer effects of flavonoids seem to differentially depend on the cellular type and origin of cervical carcinoma creating possibilities for specific targeting in the future. Besides the cytotoxic activity per se, several flavonoids can also contribute to the increase in efficacy of conventional therapies rendering tumor cells more sensitive to standard chemotherapeutics and irradiation. Although the current knowledge is still rather scarce and further studies are certainly needed, it is clear that natural flavonoids may have a great potential to benefit cervical cancer patients.

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Section: Characteristic Features Of Cytotoxic Activity Of Flavonoids mentioning

confidence: 99%

Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells

Sak¹

2014

Asian Pacific Journal of Cancer Prevention

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“…2 Ficus pumila, synonymous to Ficus repens, is an ornamental plant from the family Moraceae. It is native to East Asia, specifically South China through to Malaysia.…”

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confidence: 99%

Anti-proliferative effect of Ficus pumila Linn. on human leukemic cell lines

Larbie

Appiah–Opong

Acheampong

et al. 2015

Int J Basic Clin Pharmacol

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INTRODUCTIONCancer is one of the most severe health problems in both developing and developed countries worldwide. Among the most common types of cancers are lung, stomach, colorectal, liver, and breast. Lung cancer is the most commonly diagnosed cancer in men whereas breast cancer is the most common type in women.1 Curative surgery is the first option for patients with early-stage cancer while radiotherapy and chemotherapy have proven to be effective treatments for patients in the advanced stages. However, the curative effect of traditional chemotherapeutic drugs is limited and their ABSTRACT Background: Cancer is one of the many diseases of global concern due to its high mortality rate with drug resistance becoming a major challenge to chemotherapy and this have propelled many cancer patients to seek alternative and complementary methods of treatment. The objective for this study was, therefore, to determine the antiproliferative activity as well as phytochemical, total phenolic content (TPC), and antioxidant activity of the stem and leaf extracts (FPS and FPL) of Ficus pumila (L.) using standard methods. Methods: The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used to evaluate anti-proliferative effect and spectrophotometric-based assays for antioxidant and TPC. Phytochemical constituents were accessed by standard methods. Results:The hydroethanolic extracts of the leaves and stems were rich in tannins, general glycosides, saponins, terpenoids, alkaloids, flavonoids (leaves only), and sterols (stem only). Strong total antioxidant activities were observed with FPL and FPS with EC 50 values of 0.07 mg/ml and 0.089 mg/ml, respectively. All the crude extracts showed anti-proliferative effect towards the three human leukemic cell lines used (Jurkat, CEM,. However, FPL gave the strongest inhibition concentration at 50% values of 130.97 µg/ml (Jurkat) and 56.31 µg/ml (HL-60). Conclusion: These findings suggest that crude extracts of FPS and FPL have antiproliferative effect on the leukemia cells. The antioxidant properties of the plant including phenolics may be partly responsible for the anti-proliferative activity. Further studies are required to isolate chemical components of the plant and establish their anti-proliferative activities and mechanism of action.

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“…Moreover, karyomorphism of the cells was also affected followed by triggering of apoptotic pathway. Levels of three molecular markers of apoptotic pathway, Fas, FasL and cleaved caspase-8 were also found to be elevated in the extract-treated HeLa cells (Zhu et al, 2013).…”

Section: Indian Gooseberrymentioning

confidence: 94%

“…Flavonoid constituent, quercetin is also present Yang and Liu, 2014;Mahata et al, 2013). The fruit is also rich in essential trace elements, vitamin C and several amino acids (Zhu et al, 2013).…”

Section: Indian Gooseberrymentioning

confidence: 99%

Polyphenols derived from four indigenous Indian fruits for cancer chemoprevention and chemotherapy

Sutapa¹,

Vansh²,

Agarwal³

et al. 2016

J. Med. Plants Res.

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Cancer is one of the major causes of death worldwide, including developing and underdeveloped nations. Mortality and morbidity data suggest that incidences are higher than those of the cardiovascular diseases. High cost and occurrence of numerous side and adverse effects associated with conventional anticancer regimes has necessitated shifting the focus towards the practice of traditional alternative and complementary medicine. Emerging evidence on the beneficial link of dietary components with lower cancer occurrence has been instrumental in determining the course of cancerrelated studies. Consumption of fruits rich in polyphenols has proven to inhibit the process of carcinogenesis and tumor growth, with positive outcomes in terms of survival and quality of life of the patient and thus should be encouraged to combat cancer. The objective of the present review is to highlight the underlying mechanisms of apoptosis induced by the different polyphenolic constituents in four Indian fruits, namely litchi, Indian gooseberry, Indian blackberry and Ziziphus jujube. However, it must be kept in mind that benefits of consuming fruits rich in polyphenols should not be over-judged through food fortification or supplementation with these active principles. Conclusive evidence of the beneficial effects is yet to come through future studies in humans since most of the data have been obtained from in vitro studies.

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Polyphenol extract of Phyllanthus emblica (PEEP) induces inhibition of cell proliferation and triggers apoptosis in cervical cancer cells

Cited by 40 publications

References 17 publications

Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells

Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells

Anti-proliferative effect of Ficus pumila Linn. on human leukemic cell lines

Polyphenols derived from four indigenous Indian fruits for cancer chemoprevention and chemotherapy

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