Polyphenol intake and cardiovascular risk factors in a population with type 2 diabetes: The TOSCA.IT study

Vitale, Marilena; Vaccaro, Olga; Masulli, Maria; Bonora, Enzo; Prato, Stefano Del; Giorda, Carlo; Nicolucci, Antonio; Squatrito, Sebastiano; Auciello, Stefania; Babini, A. C.; Bani, Laura; Buzzetti, Raffaella; Cannarsa, Emanuela; Cignarelli, Mauro; Cigolini, M.; Clemente, Gennaro; Cocozza, Sara; Corsi, L.; D’Angelo, Federica; Dall’Aglio, Elisabetta; Cianni, Graziano Di; Fontana, Lucia; Gregori, Giovanna; Grioni, Sara; Giordano, Carla; Iannarelli, R.; Iovine, C; Lapolla, Annunziata; Lauro, Davide; Laviola, Luigi; Mazzucchelli, Chiara; Signorini, Stefano; Tonutti, Laura; Trevisan, Roberto; Zamboni, Chiara; Riccardi, Gabriele; Rivellese, Angela Albarosa

doi:10.1016/j.clnu.2016.11.002

Cited by 63 publications

(45 citation statements)

References 32 publications

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“…For instance, mean polyphenol intake of an adult subject is about 283–1000 mg of total polyphenols/day in France [10, 11], 500–1100 mg/day in Spain [12], about 700 mg/d in Italy [13, 14], 890 mg/day in Finland [15], 534 mg/day in Brazil [16], and around 1500 mg/day in Japan [17], while total flavonoid intake is about 190 mg/day in the UK and Ireland [18], about 240–350 mg/day in the US [19, 20], around 450 mg/day in Australia [21], between 50 and 500 mg/day in China [22], and around 320 mg/day in Korea [23]. In addition, there is a great variability in polyphenol intake within countries depending on the type of diet consumed.…”

Section: Phenolic Compounds: Occurrence Intake and Bioavailabilitymentioning

confidence: 99%

“…In the TOSCA.IT study with type 2 diabetic patients, high polyphenol intake is associated with slightly lower levels of LDL and triglycerides and higher levels of HDL cholesterol [14]. In the Moli-sani cohort, higher intakes of polyphenols were associated with lower total and LDL cholesterol, lower triglycerides, and higher levels of HDL cholesterol [69].…”

Section: Effects Of Polyphenol Intake On the Metabolic Syndromementioning

confidence: 99%

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Effects of Polyphenol Intake on Metabolic Syndrome: Current Evidences from Human Trials

Chiva‐Blanch

Badimon

2017

Oxidative Medicine and Cellular Longevity

167

105

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Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors which severely increases the risk of type II diabetes and cardiovascular disease. Several epidemiological studies have observed a negative association between polyphenol intake and MetS rates. Nevertheless, there are relatively small numbers of interventional studies evidencing this association. This review is focused on human interventional trials with polyphenols as polyphenol-rich foods and dietary patterns rich in polyphenols in patients with MetS. Current evidence suggests that polyphenol intake has the potential to alleviate MetS components by decreasing body weight, blood pressure, and blood glucose and by improving lipid metabolism. Therefore, high intake of polyphenol-rich foods such as nuts, fruits, vegetables, seasoning with aromatic plants, spices, and virgin olive oil may be the cornerstone of a healthy diet preventing the development and progression of MetS, although there is no polyphenol or polyphenol-rich food able to influence all MetS features. However, inconsistent results have been found in different trials, and more long-term randomized trials are warranted to develop public health strategies to decrease MetS rates.

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Section: Phenolic Compounds: Occurrence Intake and Bioavailabilitymentioning

confidence: 99%

Section: Effects Of Polyphenol Intake On the Metabolic Syndromementioning

confidence: 99%

Effects of Polyphenol Intake on Metabolic Syndrome: Current Evidences from Human Trials

Chiva‐Blanch

Badimon

2017

Oxidative Medicine and Cellular Longevity

167

105

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“…Accumulating evidence suggests that many dietary factors like antioxidants (polyphenols) are used alone or in combination with traditional/conventional chemotherapy to prevent or treat cancer [26][27][28][29][30][31][32][33][34][35]. Crude and processed plant extracts are studied extensively to evaluate its role in treatment as chemopreventive drug or to use in combination that can synergistically improve the outcome of current chemotherapy and lower the toxicity [36][37][38].…”

Section: Discussionmentioning

confidence: 99%

“…Crude and processed plant extracts are studied extensively to evaluate its role in treatment as chemopreventive drug or to use in combination that can synergistically improve the outcome of current chemotherapy and lower the toxicity [36][37][38]. European Prospective Investigation into Cancer and Nutrition is one such agency that studies the relationship between diet and cancer [29,[39][40][41].…”

Section: Discussionmentioning

confidence: 99%

Correlation of Antioxidant and Antiproliferative Activity of Amla and Ginger

Kulsum¹,

Suresh²,

Mehta

2018

Asian J Pharm Clin Res

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Objective: Our study focused on evaluating the anticancer property of ascorbic acid and aqueous extract of amla and ginger.Methods: Antioxidant capacity of ascorbic acid, aqueous extract of amla, and ginger was obtained by 2,2-diphenyl-1-picrylhydrazyl method and total antioxidant capacity (TAC). Vero cell line, PA-1, Cal-27, Cal-27 CisR, and DysMSCTR16 cell lines were treated with antioxidants to evaluate its antiproliferative property using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Colony and spheroid formation assays were also carried out in the presence of extracts to assess its role in anticancer stem cell activity.Results: Two volumes of amla 5 µl (~0.016 g) and 25 µl (~0.08 g) and ginger 5 µl (~0.02 g) and 25 µl (~0.1 g) showed TAC activity equivalent to 0.25 mM and 2 mM ascorbic acid, respectively. Amla and ascorbic acid showed significant antiproliferative property in normal (Vero) p=0.05, cancer (PA-1, Cal-27) p=0.005, and resistant (Cal-27 CisR) p=0.05 cell lines and ginger extract in Vero and Cal-27 cell lines (p=0.05). In PA-1 and Cal-27 CisR cell line, ginger extract showed proliferative activity (p=0.005). Antioxidants showed no antiproliferative activity in DysMSCTR16 cells. Amla extract and ascorbic acid showed significant inhibitory effect on spheroid (p=0.005) and colony formation capacity (p=0.0005) among dysplastic, cancer, and resistant cell lines. Ginger showed inhibitory effect (p=0.05) only in colony formation capacity. Conclusion:Overall, we found a strong correlation between antioxidant and antiproliferative activity of ascorbic acid, amla, and ginger. Amla and ascorbic acid proved to be effective in controlling cell proliferation and self-renewal properties of cancer cells. However, ginger was found to have selective and less antiproliferative effect in comparison to amla.

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“…Observational studies indicated that diet is one of the factors, which might prevent diabetes and its complications (94). The TOSCA-IT (the influence of dietary fat and carbohydrates proportions on plasma lipids, glucose control and low-grade inflammation in patients with type 2 diabetes) study demonstrated that a diet characterized by a higher intake of total polyphenols was associated with a better cardiovascular risk factors profile and a lower grade of subclinical inflammation in population with diabetes mellitus type 2 (95).…”

Section: Diabetes Mellitusmentioning

confidence: 99%

The role of nutraceuticals in the prevention of cardiovascular disease

Sosnowska

Penson

Banach

2017

Cardiovasc. Diagn. Ther.

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IntroductionCardiovascular disease (CVD) is common, indeed the majority of adults above sixty years of age will experience some manifestation of CVD. Based on data from 2012 and 2013, it has been estimated that CVD is responsible for 17.3 million deaths annually worldwide (1). Morbidity is also high, and in Europe, 200 billion Euros of healthcare expenditure is attributable to CVD (2). Risk factors for CVD can be categorized as modifiable and non-modifiable. Modifiable risk factors include obesity, hypertension, hyperlipidemia, diabetes mellitus, metabolic syndrome and lifestyle risk factors such as unhealthy diet, smoking and physical inactivity. Dietary factors are also important contributors to cardiovascular risk, either directly, or through their effects on other risk factors including hypertension, dyslipidemia and diabetes mellitus (3). Reduction of risk factors in the population, especially blood pressure reduction and lipid-lowering can have important impacts upon mortality from CVD (4).Protective effects against CVD have been demonstrated for several foods and dietary supplements (5) thus presenting new possibilities for population-level reduction of CVD risk. Evidence suggests that this approach is very promising. For example, in the PREDIMED observational study, participants in the highest quintile of polyphenol consumption had a relative risk of CVD of 54% compared to those in the lowest quintile (6). The aim of this review is to present an update on the most recent evidence relating to the use of nutraceuticals in the context of the prevention and treatment of CVD. Unfortunately, few studies have measured the associations between nutraceutical consumptions and "hard" outcomes such as mortality. Large randomized controlled trials are particularly rare, and thus there is a paucity of evidence in this area. Thus, our discussion will be largely focused on the effects of NutraceuticalsThe term "nutraceuticals" was introduced by Stephen DeFelice, founder and chairman of the Foundation for Innovation in Medicine, in 1989. A nutraceutical is defined as a "food, or parts of a food, that provide medical or health benefits, including the prevention and treatment of disease" (7). The definition encompasses medicinal products made from natural ingredients. Several classes of nutraceuticals have been proposed to have potential benefits in the treatment of CVD and the ones with the strongest evidence are briefly summarized below. Sterols/stanolsPlant sterols/stanols are phytosterols, and have been identified in a range of plant products including various fruits and vegetables, cereals, seeds and nuts. Their biological activity results from their molecular structural similarity to cholesterol (8). PolyphenolsPolyphenols are phytochemicals with widespread distribution in foods of plant origin. They are found in fruits, vegetables, cereal and legumes. Additionally, they are found in beverages produced from plant products such as tea, coffee, wine and cocoa. Polyphenols are structurally diverse, and over 8,000 have...

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Polyphenol intake and cardiovascular risk factors in a population with type 2 diabetes: The TOSCA.IT study

Abstract: http://www.clinicaltrials.gov; Study ID number: NCT00700856.

Cited by 63 publications

References 32 publications

Effects of Polyphenol Intake on Metabolic Syndrome: Current Evidences from Human Trials

Effects of Polyphenol Intake on Metabolic Syndrome: Current Evidences from Human Trials

Correlation of Antioxidant and Antiproliferative Activity of Amla and Ginger

The role of nutraceuticals in the prevention of cardiovascular disease

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