2022
DOI: 10.3390/molecules27051515
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Polyphenol Oxidase as a Promising Alternative Therapeutic Agent for Cancer Therapy

Abstract: Cancers have always been the most difficult to fight, the treatment of cancer is still not considered. Thus, exploring new anticancer drugs is still imminent. Traditional Chinese medicine has played an important role in the treatment of cancer. Polyphenol oxidase (PPO) extracted from Edible mushroom has many related reports on its characteristics, but its role in cancer treatment is still unclear. This study aims to investigate the effects of PPO extracted from Edible mushroom on the proliferation, migration, … Show more

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Cited by 4 publications
(2 citation statements)
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“…Tyrosinase, also known as polyphenol oxidase (PPO), is a multifunctional enzyme that controls melanin production from tyrosine [37]. Interestingly, PPO extracted from edible mushrooms significantly inhibited cancer cells' proliferation, migration, and invasion capability and promoted apoptosis in breast cancer cells [38]. Although anthocyanin and PPO are known for their antioxidant activity [39], most studies focus on anthocyanin and polyphenol oxidase relationships in plants rather than humans.…”
Section: Resultsmentioning
confidence: 99%
“…Tyrosinase, also known as polyphenol oxidase (PPO), is a multifunctional enzyme that controls melanin production from tyrosine [37]. Interestingly, PPO extracted from edible mushrooms significantly inhibited cancer cells' proliferation, migration, and invasion capability and promoted apoptosis in breast cancer cells [38]. Although anthocyanin and PPO are known for their antioxidant activity [39], most studies focus on anthocyanin and polyphenol oxidase relationships in plants rather than humans.…”
Section: Resultsmentioning
confidence: 99%
“…PPO is important for the biosynthesis of flavonoids, lignin and tannins in plants [ 4 ]. PPO has been exploited in various fields such as health, medicine and pharmaceuticals [ 7 ]. Due to the potentials of polyphenol oxidase as a catalyst for oxidative conversion of phenolic substrates, it has been deployed for use in various biotechnological applications [ 8 ].…”
Section: Introductionmentioning
confidence: 99%