Polyphenol protection and treatment of hypertension

Hügel, Helmut; Jackson, Neale; May, Brian H.; Zhang, Anthony Lin; Xue, Charlie Changli

doi:10.1016/j.phymed.2015.12.012

Cited by 159 publications

(105 citation statements)

References 117 publications

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“…Several studies suggest that the effect of isoflavones on endothelial function may be related to individual capacity to metabolize daidzein into equol [59]. Recently, a double-blind crossover study demonstrated significant improvements in arterial stiffness, blood pressure, and endothelial function with the consumption of purified equol supplements, but only among equol-producing men [60].…”

Section: Interventional Studies Involving Soymentioning

confidence: 99%

Beyond the Cholesterol-Lowering Effect of Soy Protein: A Review of the Effects of Dietary Soy and Its Constituents on Risk Factors for Cardiovascular Disease

et al. 2017

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The hypocholesterolemic effect of soy is well-documented and this has led to the regulatory approval of a health claim relating soy protein to a reduced risk of cardiovascular disease (CVD). However, soybeans contain additional components, such as isoflavones, lecithins, saponins and fiber that may improve cardiovascular health through independent mechanisms. This review summarizes the evidence on the cardiovascular benefits of non-protein soy components in relation to known CVD risk factors such as hypertension, hyperglycemia, inflammation, and obesity beyond cholesterol lowering. Overall, the available evidence suggests non-protein soy constituents improve markers of cardiovascular health; however, additional carefully designed studies are required to independently elucidate these effects. Further, work is also needed to clarify the role of isoflavone-metabolizing phenotype and gut microbiota composition on biological effect.

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Section: Interventional Studies Involving Soymentioning

confidence: 99%

Beyond the Cholesterol-Lowering Effect of Soy Protein: A Review of the Effects of Dietary Soy and Its Constituents on Risk Factors for Cardiovascular Disease

et al. 2017

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“…Furthermore, several mechanisms of SBP reduction by CGA and it metabolites such as, inhibition of nicotinamide adenine dinucleotide phosphate oxidase expression and activity, reduced free radical production, directly scavenging free radicals, stimulation of NO production by the endothelial-dependent pathway, and inhibition of angiotensin-converting enzyme in the plasma [35]. Hypotension effect of GCE could be influenced by roasting condition which that increase antioxidant activity [36].…”

Section: Lukitasari Et Almentioning

confidence: 99%

Light-Roasted Green Coffee Extract Improved Adiponectin, Insulin Resistance, and Metabolic Profile of Metabolic Syndrome Rat Model

Lukitasari

Nugroho

Rohman

et al. 2017

Asian J Pharm Clin Res

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Objective: The objective of this study is to investigate the effect of light-roasted green coffee bean extract (GCE) administration for 7 weeks on the improvement of metabolic profile, adiponectin level, homeostatic model assessment insulin resistance (HOMA-IR) index in metabolic syndrome (MS) rat model. Methods:Adult male Sprague-Dawley rats were induced by a combination of high sucrose and high-fat diet for 8 weeks and streptozotocin injection in the 2 nd week. The MS was confirmed by NCEP-ATP III criteria. They were divided into six weight-matched groups (n=5), normal control, MS, metformin and simvastatin-treated group (DMS), 100 and 200/body weight (bw) GCE (GCE 100 and GCE 200, respectively). The extracts were given through oral gavage daily for 7 weeks. The effect of GCE on body weight, serum glucose, triglyceride, (TG) and high-density lipoprotein (HDL) level was analyzed by colorimetric method. HOMA-IR index and adiponectin were analyzed by enzyme-linked immunosorbent assay methods.Result: Fasting blood glucose, TG, and systolic blood pressure decreased significantly (p<0.05) in both GCE groups. Moreover, after 7 weeks, those parameters were significantly lower (p<0.05) compared to that of MS group. Only GCE 100 group that showed a significant decrease in HDL level. GCE 100 mg/bw and 200 mg/bw group showed significantly higher adiponectin level compared to that of MS and DMS group. Furthermore, GCE 100, GCE 200, and DMS group showed a significant lower HOMA-IR index compared to that of MS group. Conclusion: 7 weeks GCE administration could decrease fasting blood glucose, profile lipid, blood pressure, and improved adiponectin level and HOMA-IR index.

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“…Adicionalmente, estudios in vitro muestran un aumento en la actividad y expresión de la óxido nítrico sintasa endotelial (eNOS) e inhibición de la NADPH oxidasa endotelial en respuesta a polifenoles, lo que podría explicar, en parte, su efecto modulador sobre la función endotelial 50,51 . Por otro lado, los efectos anti-hipertensivos descritos son mediados por la supresión de la síntesis de endotelina-1, y la inhibición de la enzima convertidora de angiotensina-1 (ECA) 52 . En el tracto gastrointestinal superior, los polifenoles, al igual que otros antioxidantes, actuarían reduciendo los hidroperóxidos de los alimentos ingeridos y formando complejos con metales de transición, contribuyendo a contrarrestar el estrés oxidativo postprandial 53 .…”

Section: Antioxidantesunclassified