Polyphenol rich extracts of finger millet and kodo millet ameliorate high fat diet-induced metabolic alterations

Khare, Pragyanshu; Maurya, Ruchika; Bhatia, Ruchika; Mangal, Priyanka; Singh, Jasmeet; Koteswaraiah, Podili; Bishnoi, Mahendra; Kondepudi, Kanthi Kiran

doi:10.1039/d0fo01643h

Cited by 47 publications

(26 citation statements)

References 43 publications

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“… 89 Millet shell polyphenols (MSPs) extracted from the cereal husks have anti-atherosclerotic effects in vitro . 90–92 Liu et al used ApoE-/- mice fed a high-fat diet as experimental subjects to investigate the anti-atherosclerotic activity of MSPs in vivo and found that MSPs effectively inhibited the development of atherosclerotic plaques, reduced the levels of related inflammatory factors, and significantly upregulated the expression levels of tight junction proteins (ocludin, zona occludens-1 and claudin 1) at the mRNA and protein levels; also, MSPs significantly altered the structure of mouse gut microbiota, in which Oscillospira and Ruminococcus were significantly enriched. 37 TOTUM-63 (T-63) is a polyphenol-rich plant extract that can have beneficial effects on the body weight and the insulin resistance in mice on a high-fat diet (HFD).…”

Section: Factors Affecting the Abundance Of Oscillospiramentioning

confidence: 99%

Oscillospira - a candidate for the next-generation probiotics

et al. 2021

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Oscillospira is a class of organism that often appears in high-throughput sequencing data but has not been purely cultured and is widely present in the animal and human intestines. There is a strong association between variation in Oscillospira abundance and obesity, leanness, and human health. In addition, a growing body of studies has shown that Oscillospira is also implicated in other diseases, such as gallstones and chronic constipation, and has shown some correlation with the positive or negative changes in its course. Sequencing data combined with metabolic profiling indicate that Oscillospira is likely to be a genus capable of producing short-chain fatty acids (SCFAs) such as butyrate, which is an important reference indicator for screening “next-generation probiotics “. Considering the positive effects of Oscillospira in some specific diseases, such as obesity-related metabolic diseases, it has already been characterized as one of the next-generation probiotic candidates and therefore has great potential for development and application in the future food, health care, and biopharmaceutical products.

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Section: Factors Affecting the Abundance Of Oscillospiramentioning

confidence: 99%

Oscillospira - a candidate for the next-generation probiotics

et al. 2021

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“…However, only the kodo millet polyphenol extracts significantly increased the quantitative insulin sensitivity check index. Further analysis indicated that the extracts of finger millet chiefly included catechin, vanillic, chlorogenic, and protocatechuic acids whereas taxifolin acid was the main phenolic in kodo millet extracts (46). In addition, Ofosu et al reported that ethanol extracts containing soluble polyphenols of finger millet significantly increased inhibitory activity (IC50 = 18.07 µg/ml).…”

Section: The Relationship Between the Hypoglycemic Effect Of Millet P...mentioning

confidence: 99%

Effect of Different Processing Methods on the Millet Polyphenols and Their Anti-diabetic Potential

Wang

Zhao

et al. 2022

Front. Nutr.

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Interest in polyphenols has grown due to their beneficial effect on diabetes attenuation. Millets are ancient crops that are rich in polyphenols and used for both food and feed. They are grown worldwide and are adapted to production under dry, hot conditions. The polyphenols found in millets have anti-diabetic properties. However, millet is usually consumed after being processed by heating, germination, fermentation, and other processing methods, which may alter polyphenol content and thus affect their anti-diabetic potential. This mini-review profiles the effects of different processing methods on millet polyphenols and how changes in millet polyphenols affect the hypoglycemic effect of millet. Future studies are needed to compare the anti-diabetes potential of millet polyphenols before and after processing and to explore ways to minimize polyphenol losses and thus maintain their hypoglycemic effect in final products.

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“…Epicatechin-3-gallate is a major catechin compound that showed beneficial effects in earlier reports of diabetes, Parkinson's disease, Alzheimer's disease, obesity, and stroke [56][57][58]. Khare et al [98] quantified 1.10 ppm concentration of catechin in kodo millets, which showed anti-obesity effects.…”

Section: Catechinmentioning

confidence: 99%

“…Naringin increases the alkaline phosphatase (ALP) activity [100], osteocalcin [101], and osteocalcin activity [102]. Khare et al [98] reported 11.97 ppm quantity of naringin in kodo millets with various health benefits.…”

Section: Naringinmentioning

confidence: 99%

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Understanding the Antinutritional Factors and Bioactive Compounds of Kodo Millet (Paspalum scrobiculatum) and Little Millet (Panicum sumatrense)

Dey

Saxena

Kumar

et al. 2022

Journal of Food Quality

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Kodo and little millet (Kutki) have a variety of phytochemical constituents including derivatives of hydroxybenzoic acid and hydroxycinnamic acids, myricetin, catechin, luteolin, apigenin, daidzein, naringenin, kaempferol, and quercetin with vast health benefits and thus can be utilized as functional food ingredients. Millet-based foods and their food products have physiological and health-promoting impacts, notably antidiabetic, anti-obesity, and cardiovascular disease, and based on the actions of phytochemicals, it plays a major role in the body’s immune system. However, antinutrients (tannins, oxalate, trypsin inhibitor, and phytates) present in these millets restrict their utilization since these factors bind the essential nutrients and make them unavailable. Therefore, this review suggested overcoming the effects of antinutrients in these millets, thereby opening up important applications in food industries that may promote the development of novel functional foods. Various methods were discussed to eliminate the antinutrient factors in these millets, and hence, the review holds immense significance to the food industry for effectively utilizing these millets to develop value-added RTE/RTC products/functional food/beverages.

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Polyphenol rich extracts of finger millet and kodo millet ameliorate high fat diet-induced metabolic alterations

Abstract: Taxifolin (98%) and catechin (86.6%) are the major polyphenols in KM-PRE and FM-PRE. FM-PRE and KM-PRE prevent obesity, hepatic steatosis, and gut bacterial dysbiosis however, the effects of KM-PRE are more profound compared to FM-PRE.

Cited by 47 publications

References 43 publications

Oscillospira - a candidate for the next-generation probiotics

Oscillospira - a candidate for the next-generation probiotics

Effect of Different Processing Methods on the Millet Polyphenols and Their Anti-diabetic Potential

Understanding the Antinutritional Factors and Bioactive Compounds of Kodo Millet (Paspalum scrobiculatum) and Little Millet (Panicum sumatrense)

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