Polyphenol supplementation alters intramuscular apoptotic signaling following acute resistance exercise

Townsend, Jeremy R.; Stout, Jeffrey R.; Jajtner, Adam R.; Church, David D.; Beyer, Kyle S.; Riffe, Joshua J.; Muddle, Tyler W.D.; Herrlinger, Kelli L.; Fukuda, David H.; Hoffman, Jay R.

doi:10.14814/phy2.13552

Cited by 12 publications

(13 citation statements)

References 57 publications

(154 reference statements)

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“…[65][66][67][68][69] The use of ultrasound during the pre-microbiopsy procedure was reported in 7 studies to safely identify and verify the muscle group depth, and subcutaneous adipose tissue thickness for both vastus lateralis and other muscle groups for sampling. 35,36,45,46,48,50,70 One study reported measuring skinfold thickness to estimate the depth of the biopsy needle 69 ; however, they did not report their protocol. Prior to the introduction of the microbiopsy needle, numerous authors reported that an incision was made in the skin and fascia with a hypodermic needle (14, 18, and 23 G) 23,50,71,72 or a co-axial/ cannula introducer 35,37,55,[73][74][75][76][77][78][79] to create or maintain a "pilot hole" for multiple passes if the study design required larger sample size (mg) per time point for analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Five studies reported the use of a superficial lidocaine/prilocaine cream or lidocaine tape as a local anesthetic prior to the microbiopsy procedure 65–69 . The use of ultrasound during the pre‐microbiopsy procedure was reported in 7 studies to safely identify and verify the muscle group depth, and subcutaneous adipose tissue thickness for both vastus lateralis and other muscle groups for sampling 35,36,45,46,48,50,70 . One study reported measuring skinfold thickness to estimate the depth of the biopsy needle 69 ; however, they did not report their protocol.…”

Section: Resultsmentioning

confidence: 99%

“…Acute resistance exercise [ 23,[41][42][43][44][45][46]51,53,62,66,70,[74][75][76]78,79,84,85,87,97 Supplemental agents with or without exercise [ 11,[43][44][45]47,48,64,70,78,79,85,98,113 ] Post-resistance exercise alcohol consumption [ 62 ] Thermotherapy (heat stress) [ 67 ] Cryotherapy (cold stress) [ 83,107 ]…”

Section: Treatments Referencesmentioning

confidence: 99%

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The skeletal muscle microbiopsy method in exercise and sports science research: A narrative and methodological review

Newmire

Willoughby

2022

Scandinavian Med Sci Sports

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Background The skeletal muscle microbiopsy protocol was introduced to the Exercise and Sports Science (ESS) research field in 1999 and has been used as a protocol to directly examine muscular structural and biochemical changes. There is much variation in the reporting of the microbiopsy protocol and its related pre‐ and post‐procedure for participant care and sample collection. The purpose of this narrative and methodological review is to compare the microbiopsy to the traditional Bergström protocol used in the ESS field, identify and summarize all related microbiopsy protocols used in previous ESS studies and determine the most frequently used microbiopsy protocols aspects and associated pre‐ and post‐biopsy procedures. Methods A review of literature up to January 2022 was used following the PRISMA and Cochrane Methodological Review Guide to determine frequently used methods that may facilitate optimal and potential recommendations for muscle microbiopsy needle gauge (G), concentration or dose (% or ml) and administration of local anesthetic, co‐axial/cannula introducer gauge (G), muscle depth (cm), muscle sample size collected (mg), passes to collect samples, time points of muscle sampling, and promotion of participant compliance and minimization of adverse events. Results Eighty‐five articles were selected based on the inclusionary requirements related to the ESS field or methodological considerations. The most frequently reported aspects in previous research to suggest the location of the vastus lateralis is the midpoint between the patella and the greater trochanter of the femur or 1/3 or 2/3 the distance from the patella to anterior superior iliac spine, 14 G biopsy needle, subcutaneous injected lidocaine administration (2 ml, 1%), 13 G co‐axial/cannula, 1–2 cm muscle depth, 10–20 mg of muscle sample, ~3‐time points, and 2–3 passes. Discussion There is much variation in the reporting of the microbiopsy protocol and its related pre‐ and post‐biopsy procedures. Standardization in reporting may promote recommendations to optimize data integrity, participant safety, participant adherence to the study design, and increase reproducibility. Recommendations are made for the microbiopsy procedure based on frequently reported characteristics.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The skeletal muscle microbiopsy method in exercise and sports science research: A narrative and methodological review

Newmire

Willoughby

2022

Scandinavian Med Sci Sports

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“…EGCG was reported to reduce chondrocyte apoptosis during osteoarthritis in rat models by activating autophagy [ 105 ]. Green tea supplementation could effectively suppress the activation of autophagy inhibitors, thereby reducing muscle damage [ 106 ] and reducing ROS accumulation [ 107 ].…”

Section: Herbal Teas and Autophagymentioning

confidence: 99%

Role of Herbal Teas in Regulating Cellular Homeostasis and Autophagy and Their Implications in Regulating Overall Health

et al. 2021

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Tea is one of the most popular and widely consumed beverages worldwide, and possesses numerous potential health benefits. Herbal teas are well-known to contain an abundance of polyphenol antioxidants and other ingredients, thereby implicating protection and treatment against various ailments, and maintaining overall health in humans, although their mechanisms of action have not yet been fully identified. Autophagy is a conserved mechanism present in organisms that maintains basal cellular homeostasis and is essential in mediating the pathogenesis of several diseases, including cancer, type II diabetes, obesity, and Alzheimer’s disease. The increasing prevalence of these diseases, which could be attributed to the imbalance in the level of autophagy, presents a considerable challenge in the healthcare industry. Natural medicine stands as an effective, safe, and economical alternative in balancing autophagy and maintaining homeostasis. Tea is a part of the diet for many people, and it could mediate autophagy as well. Here, we aim to provide an updated overview of popular herbal teas’ health-promoting and disease healing properties and in-depth information on their relation to autophagy and its related signaling molecules. The present review sheds more light on the significance of herbal teas in regulating autophagy, thereby improving overall health.

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“…Finally, 2 studies unexpectedly showed increased CK levels in the groups that received GT and BT supplementation compared with the placebo group (24,61). The authors suggested that the use of muscle biopsies could have influenced muscle damage and inflammation results.…”

Section: Muscle Damagementioning

confidence: 99%

Green Tea and Black Tea for Exercise Recovery: A Systematic Review

Zapata

Hewlings

2021

Strength &Amp; Conditioning Journal

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Green tea and black tea are rich in polyphenols that have shown antioxidant and anti-inflammatory properties. The objective of this systematic review was to determine the effect of green tea and black tea supplementation on exercise recovery indicated by oxidative stress, inflammation, muscle damage, and muscle function. An online search was conducted using PubMed, SPORTDiscus, and CINAHL. Eligible studies were peer-reviewed, randomized controlled trials with parallel or crossover design including healthy participants that received acute or chronic supplementation with green tea or black tea, independently or in combination, taken before, during, or after exercise. Sixteen studies were included with a total of 375 trained or untrained male participants. Few studies demonstrated that green tea or black tea supplementation can promote exercise recovery by reducing oxidative stress, inflammation, muscle damage, muscle soreness, or loss of strength after high-intensity exercise. However, there were multiple inconsistencies and limitations in the studies' methodology, and few studies measured muscle soreness and loss of strength postexercise. Differences in the population studied, exercise protocol, supplementation strategy, bio-markers chosen, and timing of their measurement may explain some of the inconsistencies in the results. More research is needed to understand the potential of green tea and black tea on exercise recovery.

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Polyphenol supplementation alters intramuscular apoptotic signaling following acute resistance exercise

Cited by 12 publications

References 57 publications

The skeletal muscle microbiopsy method in exercise and sports science research: A narrative and methodological review

The skeletal muscle microbiopsy method in exercise and sports science research: A narrative and methodological review

Role of Herbal Teas in Regulating Cellular Homeostasis and Autophagy and Their Implications in Regulating Overall Health

Green Tea and Black Tea for Exercise Recovery: A Systematic Review

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