Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease

Lekakis, John; Rallidis, Lοukianos S.; Andreadou, Ioanna; Vamvakou, G.; Καζαντζόγλου, Γεώργιος; Magiatis, Prokopios; Skaltsounis, Alexios‐Léandros; Kremastinos, Dimitrios Th.

doi:10.1097/00149831-200512000-00013

Cited by 126 publications

(111 citation statements)

References 32 publications

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“…Coronary artery disease (CAD) patients showed a 2.1% improvement in FMD measured at 60 min after intake of non-alcoholized wine [20]. In another study involving CAD patients [21], FMD after consumption of 600 mg of polyphenols from red wine peaked at 60 min, which is similar to our results in elite athletes. However, maximal improvement in FMD (1.9% increase from baseline) with polyphenol intake was slightly smaller than the change seen in our population of athletes (2.8% increase from baseline).…”

Section: Study 1-polyphenols and Fmdsupporting

confidence: 86%

Acute Effects of Polyphenols from Cranberries and Grape Seeds on Endothelial Function and Performance in Elite Athletes

Labonté

Couillard

Motard-Belanger

et al. 2013

Sports

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Abstract:We examined how intake of polyphenols modifies brachial artery flow-mediated dilation (FMD) at rest, and cycling anaerobic performance, in elite athletes. In the first randomized cross-over study, FMD was measured over a three-hour period on two occasions in eight elite male and female athletes after acute consumption of either polyphenols from cranberries and grape seeds (600 mg) or a polyphenol-free placebo drink. Consumption of the polyphenol-rich drink led to a significant increase in FMD compared to placebo (p = 0.02), with a peak at 60 min. In a second study, 12 elite male and female athletes completed a threekilometer time trial (TT) on an ergocycle on two occasions in random order, either after consumption of 800 mg of polyphenols or a placebo. Acute intake of the polyphenol extract had no impact on the three-kilometer time trial completion. However, plasma lactate levels were significantly lower before and after the TT when subjects consumed the polyphenols vs. placebo (p < 0.05). Results suggest that polyphenols from cranberries and grape seeds acutely modifies FMD at rest in elite athletes but this does not translate into enhanced cycling anaerobic performance. OPEN ACCESSSports 2013, 1 56

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Section: Study 1-polyphenols and Fmdsupporting

confidence: 86%

Acute Effects of Polyphenols from Cranberries and Grape Seeds on Endothelial Function and Performance in Elite Athletes

Labonté

Couillard

Motard-Belanger

et al. 2013

Sports

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“…FMD was significantly increased by each dose of resveratrol compared with placebo. These findings suggest that resveratrol may contribute to the purported cardiovascular 13 health benefits of grapes and red wine. Further research is warranted to confirm the sustainability of the effect of resveratrol on FMD.…”

Section: Discussionmentioning

confidence: 77%

“…Consumption of various polyphenol-rich food ingredients such as cocoa (9), green and black tea (10)(11), grape seed extract (12) and red wine extract (13) have been shown to acutely improve FMD in at-risk population groups. However, it is not known which specific polyphenolic compounds present in these foods are responsible for this beneficial effect.…”

Section: Introductionmentioning

confidence: 99%

Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure

Wong

Howe

Buckley

et al. 2011

Nutrition, Metabolism and Cardiovascular Diseases

255

218

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243Text 2129 Number of references 31 Number of figures 3Number of tables 1 and on FMD (P<0.01), which increased from 4.1 ± 0.8% (placebo) to 7.7 ± 1.5% after 270mg resveratrol. FMD was also linearly related to log10 plasma resveratrol concentration (P<0.01).(3) Conclusion-Acute resveratrol consumption increased plasma resveratrol concentrations and FMD in a dose-related manner. This effect may contribute to the purported cardiovascular health benefits of grapes and red wine.4

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“…In many cases, the other compounds present in the matrix used to deliver resveratrol may enhance its action, or produce their own effects [86]. For instance, 270 mg transresveratrol [66] and 600 mg of grapeskin extract containingo50 mg trans-resveratrol [87] have been found to comparably increase FMD of the brachial artery one hour following consumption, whereas 90 mg trans-resveratrol [66] tends to have a smaller effect. Ghanim's two studies illustrate this point in that six weeks of P. cuspidatum supplementation did not significantly alter either TLR4 mRNA or protein expression [51], whereas one meal with a resveratrol and grapeskin polyphenol supplement significantly increased TLR4 protein expression [52].…”

Section: Current Limitations To Human Clinical Trial Datamentioning

confidence: 99%

Resveratrol and health – A comprehensive review of human clinical trials

Smoliga

Baur

Hausenblas

2011

Molecular Nutrition Food Res

503

308

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In the past decade, the small polyphenol resveratrol has received widespread attention as either a potential therapy or as a preventive agent for numerous diseases. Studies using purified enzymes, cultured cells, and laboratory animals have suggested that resveratrol has anti-aging, anti-carcinogenic, anti-inflammatory, and anti-oxidant properties that might be relevant to chronic diseases and/or longevity in humans. Although the supporting research in laboratory models is quite substantial, only recently data has emerged to describe the effects of resveratrol supplementation on physiological responses in humans. The limited number of human clinical trials that are available has largely described various aspects of resveratrol's safety and bioavailability, reaching a consensus that it is generally well-tolerated, but have poor bioavailability. Very few published human studies have explored the ability of resveratrol to achieve the physiological benefits that have been observed in laboratory models, although many clinical trials have recently been initiated. This review aims to examine the current state of knowledge on the effects of resveratrol on humans and to utilize this information to develop further guidelines for the implementation of human clinical trials.

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Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease

Abstract: Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. These results could probably, at least partly, explain the favorable effects of red wine on the cardiovascular system.

Cited by 126 publications

References 32 publications

Acute Effects of Polyphenols from Cranberries and Grape Seeds on Endothelial Function and Performance in Elite Athletes

Acute Effects of Polyphenols from Cranberries and Grape Seeds on Endothelial Function and Performance in Elite Athletes

Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure

Resveratrol and health – A comprehensive review of human clinical trials

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