Polyphenolic fraction of Algerian propolis protects rat kidney against acute oxidative stress induced by doxorubicin

Abstract

We evaluated the effects of propolis extract on renal oxidative stress induced by doxorubicin throughout an analytical and pharmacological study of the eastern Algerian propolis using thin layer chromatography, ultra-violet-high-performance liquid chromatography) and gas chromatography-mass spectrometry. The pharmacological study was carried out in vivo on Wistar rat pre-treated with propolis extract 100 mg/kg/day for seven days. Doxorubicin at 10 mg/kg of body weight was administered intravenously on Day 7. Serum creatinine concentration, scavenging effect of flavonoids, lipid peroxidation and glutathione concentration were measured. Chemical analysis allowed identification and quantification of the phenolic compounds including pinostrombin chalcone (38.91%), galangin (18.95%), naringenin (14.27%), tectochrysin (25.09%), methoxychrysin (1.14%) and a prenylated coumarin compound suberosin (1.65%). The total flavonoid concentration in the propolis extract was 370 mg (quercetin equivalents QE) /g dry weight (QE/g DWPE). Propolis extract restored the renal functions and reduced the toxic effect of doxorubicin. These data show a protective effect of Algerian propolis extract against doxorubicin-induced oxidative stress.

Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease

“…Propolis has shown protective effects against kidney diseases. Nephropathy was prevented by propolis treatment in animal models [ 165 , 182 , 183 ]. Brazilian red propolis attenuated hypertension and renal damage in a rat renal ablation model [ 184 ].…”

Biomedical Properties of Propolis on Diverse Chronic Diseases and Its Potential Applications and Health Benefits

“…[45] Argelia Pinocembrin, chicoric and caffeic acids and their esters, galangin, diterpenic acids, chrysin, aromatic acids. [46,47] Table 1. Cont.…”

“…In a study by Touzani et al in 2019 in the Moroccan region, nine phenolic compounds were identified with different concentrations, namely, caffeic acid, p -coumaric acid, ferulic acid, naringenin, pinocembrin, chrysin, galangin, pinobanksin, and quercetin [ 45 ]. Algeria propolis is composed of pinocembrin, chicoric and caffeic acids and their esters, galangin, diterpenic acids, flavonols such as chrysin, and aromatic acids [ 46 , 47 ].…”

Exploring the Prospective Role of Propolis in Modifying Aging Hallmarks

“…Both heart and liver mitochondria undergo atypical biochemical modifications upon the introduction of antineoplastic agents doxorubicin or vinblastine [ 221 ]. These changes include a significant increase in the production of malondialdehyde and anion superoxide, as well as the activation of swelling processes and a worsening of respiratory control.…”