Polyphenols as novel interventions for depression: Exploring the efficacy, mechanisms of action, and implications for future research

Gamage, Elizabeth; Orr, Rebecca; Travica, Nikolaj; Lane, Melissa; Jacka, Felice N.; Dissanayaka, Thusharika; Kim, Jee Hyun; Grosso, Giuseppe; Godos, Justyna; Marx, Wolfgang

doi:10.1016/j.neubiorev.2023.105225

Cited by 8 publications

(4 citation statements)

References 304 publications

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“…Polyphenols, as natural metabolites widely found in natural medicines, have a high variety of biological capacities such as antioxidation, anti-inflammation, anti-fibrosis and anti-tumor (Luca et al, 2020). Additionally, they have low toxicity and will not accumulation in body, which are potential active ingredients of great development value for dietary supplement and drugs (Gamage et al, 2023).…”

Section: Polyphenolmentioning

confidence: 99%

The protective effect of natural medicines in rheumatoid arthritis via inhibit angiogenesis

Gao,

Song,

Chen

et al. 2024

Front. Pharmacol.

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Rheumatoid arthritis is a chronic immunological disease leading to the progressive bone and joint destruction. Angiogenesis, accompanied by synovial hyperplasia and inflammation underlies joint destruction. Delaying or even blocking synovial angiogenesis has emerged as an important target of RA treatment. Natural medicines has a long history of treating RA, and numerous reports have suggested that natural medicines have a strong inhibitory activity on synovial angiogenesis, thereby improving the progression of RA. Natural medicines could regulate the following signaling pathways: HIF/VEGF/ANG, PI3K/Akt pathway, MAPKs pathway, NF-κB pathway, PPARγ pathway, JAK2/STAT3 pathway, etc., thereby inhibiting angiogenesis. Tripterygium wilfordii Hook. f. (TwHF), sinomenine, and total glucoside of Paeonia lactiflora Pall. Are currently the most representative of all natural products worthy of development and utilization. In this paper, the main factors affecting angiogenesis were discussed and different types of natural medicines that inhibit angiogenesis were systematically summarized. Their specific anti-angiogenesis mechanisms are also reviewed which aiming to provide new perspective and options for the management of RA by targeting angiogenesis.

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Section: Polyphenolmentioning

confidence: 99%

The protective effect of natural medicines in rheumatoid arthritis via inhibit angiogenesis

Gao,

Song,

Chen

et al. 2024

Front. Pharmacol.

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“…The flavonoids rutin, quercetin, apigenin, epigallocatechin gallate, myricetin, hesperidin, kaempferol, naringenin, formononetin, beta-carotene, beta-cryptoxanthin, lutein, and genistein have been demonstrated to have antidepressant properties in animal model (10). In recent studies, there has been a negative association between phenolic acid, flavanones, and anthocyanin intake and depression symptoms (10,17,18). A high antioxidant activity is attributed to anthocyanins, which have the potential to damage DNA, activate estrogen, inhibit enzymes, inhibit inflammation, and inhibit the peroxidation of lipids (19)(20)(21).…”

Section: Relationship Between Depression and Anthocyaninmentioning

confidence: 99%

“…Akduman ve ark, Potential effects of anthocyanin on depression: A review development as a result of increasing BDNF (Brain-derived neurotrophic factor) expression by regulating the ERK/ CREB/BDNF signaling pathway (Figure 1) (18,22).…”

Section: Figure 1 Mao and Depression (Created By The Authors Based On...mentioning

confidence: 99%

Potential Effects of Anthocyanin on Depression: A Review

Kurtbeyoglu,

Akduman,

Yüksel

et al. 2024

İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi

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Nutrition is helpful in preventing depression and reducing its symptoms in depressed patients. This is because when the pathophysiology of depression is examined, deficiencies in certain nutrients are observed. Oxidative stress is also known to cause inflammation, which can contribute to the pathophysiology of the disease. We examined the effectiveness of anthocyanin, which is known to be an antioxidant, on depression. Related articles were searched in the Web of Science database. The combinations of the following terms were used for the search: “Anthocyanidin” OR “Anthocyanidins” OR “Anthocyanin” OR “Leucoanthocyanidins” AND “depression”. 71 abstracts were reviewed, 55 full-text articles were examined, and 7 papers met all of the inclusion criteria. According to these studies, anthocyanin may offer protection against depression and can alleviate its symptoms. Oxidative stress and deterioration in neurogenesis are the mechanisms behind inflammation. Various human, animal, and in vitro studies demonstrate that anthocyanins possess strong anti-inflammatory and antioxidant properties.

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“…For instance, an increased intake in dietary antioxidants (e.g., polyphenols, vitamin C, vitamin E) can alleviate symptoms of depression in humans and laboratory animals. [68,69] However, more research is needed to investigate whether dietary antioxidants can also exert beneficial effects in other situations associated with impaired welfare, whether these effects are observed in other animal species than humans and laboratory animals, and whether a dietary antioxidant supplementation could efficiently be implemented in the wild. [8]…”

Section: Targeting Positive Affective Statesmentioning

confidence: 99%

Oxidative status: A general but overlooked indicator of welfare across animal species?

Beaulieu

2024

BioEssays

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Because of their ubiquity, plasticity, and direct effects on the nervous system, markers of oxidative status may be of great value to assess animal welfare across species and conditions in the wild. However, welfare biologists have not yet seized this opportunity, possibly because the validity of these markers as welfare indicators remains questionable. A validation process was, therefore, performed here using a meta‐analytical approach considering three conditions assumed to impair the welfare of animals. With very few exceptions, two of the four considered markers consistently varied across these negatively‐valenced conditions. By highlighting the current underrepresentation of markers of oxidative status in animal welfare studies, and by concretely illustrating that some of these markers can consistently reflect negative affective states, this article aims to encourage biologists to include these physiological markers in their toolbox to better measure, monitor, and perhaps also improve the welfare of animals in their natural habitat.

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Polyphenols as novel interventions for depression: Exploring the efficacy, mechanisms of action, and implications for future research

Cited by 8 publications

References 304 publications

The protective effect of natural medicines in rheumatoid arthritis via inhibit angiogenesis

The protective effect of natural medicines in rheumatoid arthritis via inhibit angiogenesis

Potential Effects of Anthocyanin on Depression: A Review

Oxidative status: A general but overlooked indicator of welfare across animal species?

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