Polyphenols as possible bioprotectors against cytotoxicity and DNA damage induced by ochratoxin A

Cariddi, Laura Noelia; Sabini, María Carola; Escobar, Franco Matías; Montironi, Ivana Dalila; Mañas, Fernando; Iglesias, Delvis; Comini, Laura R.; Sabini, Liliana; Dalcero, Ana María

doi:10.1016/j.etap.2015.03.013

Cited by 30 publications

(18 citation statements)

References 39 publications

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“…Silibinin effectively decreased OTA-induced apoptosis in hepatocytes [ 246 ]. Luteolin, chlorogenic acid, and caffeic acid attenuated the OTA-mediated viability loss in kidney cells and lymphocytes while decreasing OTA-induced DNA damage of the blood cells of BALB/c mice [ 247 ]. Quercetin pretreatment suppressed OTA-induced cytotoxicity and oxidative stress and prevented OTA-induced apoptosis by lowering the activation of caspase cascade, DNA fragmentation, and micronucleus formation in kidney and in liver cells; these positive effects were attributed to the activation of Nrf2 pathway by quercetin causing the protection against OTA-induced alteration of the antioxidant defense [ 248 , 249 ].…”

Section: Protective Agents—overviewmentioning

confidence: 99%

Ochratoxin A: Molecular Interactions, Mechanisms of Toxicity and Prevention at the Molecular Level

Kőszegi

Poór

2016

Toxins

253

166

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Ochratoxin A (OTA) is a widely-spread mycotoxin all over the world causing major health risks. The focus of the present review is on the molecular and cellular interactions of OTA. In order to get better insight into the mechanism of its toxicity and on the several attempts made for prevention or attenuation of its toxic action, a detailed description is given on chemistry and toxicokinetics of this mycotoxin. The mode of action of OTA is not clearly understood yet, and seems to be very complex. Inhibition of protein synthesis and energy production, induction of oxidative stress, DNA adduct formation, as well as apoptosis/necrosis and cell cycle arrest are possibly involved in its toxic action. Since OTA binds very strongly to human and animal albumin, a major emphasis is done regarding OTA-albumin interaction. Displacement of OTA from albumin by drugs and by natural flavonoids are discussed in detail, hypothesizing their potentially beneficial effect in order to prevent or attenuate the OTA-induced toxic consequences.

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Section: Protective Agents—overviewmentioning

confidence: 99%

Ochratoxin A: Molecular Interactions, Mechanisms of Toxicity and Prevention at the Molecular Level

Kőszegi

Poór

2016

Toxins

253

166

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“…Animal studies with single polyphenols have generally involved treating mice or rats with a known DNA-damaging agent and looking for protection against DNA breaks, MN and chrom abs. Generally, protection is seen [54,57] though in some cases at rather high doses [56,63]. Pretreatment of rats with epicatechin reduced the level of DNA breaks induced in bone marrow cells by the topoisomerase poison etoposide [55].…”

Section: Isolated Phytochemicalsmentioning

confidence: 99%

Polyphenols and DNA Damage: A Mixed Blessing

2016

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Polyphenols are a very broad group of chemicals, widely distributed in plant foods, and endowed with antioxidant activity by virtue of their numerous phenol groups. They are widely studied as putative cancer-protective agents, potentially contributing to the cancer preventive properties of fruits and vegetables. We review recent publications relating to human trials, animal experiments and cell culture, grouping them according to whether polyphenols are investigated in whole foods and drinks, in plant extracts, or as individual compounds. A variety of assays are in use to study genetic damage endpoints. Human trials, of which there are rather few, tend to show decreases in endogenous DNA damage and protection against DNA damage induced ex vivo in blood cells. Most animal experiments have investigated the effects of polyphenols (often at high doses) in combination with known DNA-damaging agents, and generally they show protection. High concentrations can themselves induce DNA damage, as demonstrated in numerous cell culture experiments; low concentrations, on the other hand, tend to decrease DNA damage.

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“…e protective effect of ChlA on cyto-genotoxicity indu ced by different toxic su bstances has been reported (Carranza-Torres e t al., 2019). A previous study reported the short-term protective effects of ChlA on DNA damage induced by OTA in Balb/c mice aer 24 hours of intraperitoneal treatment (Cariddi et al, 2015). e present study a imed to determine the possible protective effect of orally administered ChlA on DNA damage in rats exposed to OTA for 28 days by means of micronucleus assays in bone marrow cells and comet assays in blood and kidney cells.…”

Section: Introductionmentioning

confidence: 88%

Protective role of chlorogenic acid on DNA damage caused by ochratoxin A exposure

Campra

Cariddi

Escobar

et al. 2020

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Chlorogenic acid (ChlA) has shown short-term protective effects against the cyto-genotoxic effects of ochratoxin A (OTA). The present study evaluated the effect of oral administration of ChlA in male Wistar rats exposed to OTA. OTA (0.4 mg/kg bw/day), ChlA (5 mg/kg bw/day), or the combination of both, were administered orally to animals during 28 days. No deaths, decrease in feed consumption or change in the body weight of animals were observed in any group. In the OTA-treated group a decrease in locomotion as well as increased DNA damage in blood, kidney and bone marrow cells were observed. ChlA alone was not genotoxic for animals. The combination of OTA+ChlA decreased the DNA damage by 37% in blood cells, by 55% in kidney cells and by 80% in bone marrow cells compared to OTA-treated group. In conclusion, oral treatment with ChlA showed a good protective effect on genotoxicity produced by OTA in rats during 28 days exposure.

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Polyphenols as possible bioprotectors against cytotoxicity and DNA damage induced by ochratoxin A

Cited by 30 publications

References 39 publications

Ochratoxin A: Molecular Interactions, Mechanisms of Toxicity and Prevention at the Molecular Level

Ochratoxin A: Molecular Interactions, Mechanisms of Toxicity and Prevention at the Molecular Level

Polyphenols and DNA Damage: A Mixed Blessing

Protective role of chlorogenic acid on DNA damage caused by ochratoxin A exposure

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