Polyphenols bearing cinnamaldehyde scaffold showing cell growth inhibitory effects on the cisplatin-resistant A2780/Cis ovarian cancer cells

Shin, Soon Young; Jung, Hosung; Ahn, Seunghyun; Hwang, Doseok; Yoon, Hyuk; Hyun, Jiye; Yong, Yeonjoong; Cho, Hi Jae; Koh, Dongsoo; Lee, Young Han; Lim, Yoongho

doi:10.1016/j.bmc.2014.01.058

Cited by 50 publications

(30 citation statements)

References 36 publications

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“…The 3T3L1 cells were treated with 20 lM quercetin or 20 lM kaempferide for different time periods, harvested and lysed in a buffer containing 20 mM HEPES (pH 7.2), 1 % Triton X-100, 10 % glycerol, 150 mM NaCl, 10 lg/mL leupeptin, and 1 mM phenylmethylsulfonyl fluoride (PMSF). Electrophoresis and immunoblotting were performed as previously described (Shin et al 2014). Anti-phospho-AMPKa (Thr172) was purchased from Cell Signaling Technology (Beverly, MA, USA).…”

Section: Methodsmentioning

confidence: 99%

Flavonoids activating adenosine monophosphate-activated protein kinase

Yong

Shin

Jung

et al. 2015

J Korean Soc Appl Biol Chem

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Eighteen flavonoids were tested as adenosine monophosphate-activated protein kinase (AMPK) activators. The AMPK activation induced by kaempferide was 1.75 times better than the value obtained at 100 % AMPK phosphorylation. Western blotting analysis of kaempferide demonstrated that it increased the phosphorylation of AMPK in vitro. In silico docking results carried out to elucidate the binding mode between kaempferide and AMPK showed the docking pose of kaempferide in the binding site of AMPK was similar to that of the substrate contained in the crystallographic structure of AMPK. Flavonoids, including kaempferide, are promising potential AMPK activators.

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Section: Methodsmentioning

confidence: 99%

Flavonoids activating adenosine monophosphate-activated protein kinase

Yong

Shin

Jung

et al. 2015

J Korean Soc Appl Biol Chem

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“…The 42 compounds were divided into two groups: a training set used to create the QSAR models and a test set (derivatives 2 , 4 , 12 , 15 , 24 , 29 , 30 , and 36 in Table ) used to validate the models. To confirm whether the eight derivatives used as the test set were chosen arbitrarily, hierarchical clustering analysis was performed . As shown in Figure S1, the eight derivatives belong to separate structural groups.…”

Section: Resultsmentioning

confidence: 99%

Quantitative Relationships Between the Cytotoxicity of Flavonoids on the Human Breast Cancer Stem‐Like Cells MCF7‐SC and Their Structural Properties

et al. 2015

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As some breast cancer-related deaths can be attributed to the metastasis of cancer stem cells, chemotherapeutic agents targeting breast cancer stem cells are of interest as a potential treatment. Flavonoids that exhibit cytotoxicity on breast cancer stem cells have rarely been observed. Thus, the objective of this study was to measure potential cytotoxic effects of 42 different flavonoids on the human breast cancer stem-like cell line, MCF7-SC. The relationship between flavonoid structural properties and cytotoxicity has not been reported previously; therefore, we determined quantitative structure-activity relationships using both comparative molecular field analysis and comparative molecular similarity analysis. Further biological experiments including Western blot analysis, flow cytometry, and immunofluorescence microscopy were also conducted on the most cytotoxic 8-chloroflavanone.

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“…Moreover, the biological model of action studies revealed that one of the synthesized polyphenols induced transcription factor p53‐medated upregulation of the cell cycle inhibitor P21, while silencing p53 protein resulted in a decrease in cell cycle arrest, suggesting that the antitumor activity of polyphenols is associated with p53‐mediated inhibition of cell cycle progression at G1 phase . Using the similar approach, Shin and co‐workers also demonstrated that polyphenols bearing cinnamaldehyde scaffold exhibited marked inhibitory effects on the clonogenicity of cisplatin‐resistant A2780/Cis ovarian cancer cells …”

Section: Structure‐activity Relationship Of Polyphenols As Anticancermentioning

confidence: 94%

Multifaceted ability of naturally occurring polyphenols against metastatic cancer

Zhou

Bennett

Zhou

2016

Clin Exp Pharma Physio

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SUMMARYAlthough cancer metastases are known to be the main cause of cancer-related deaths, truly effective antimetastatic therapeutics remain scarce in clinical practice. Naturally occurring polyphenols are the most abundant antioxidants in human diets. Many of them possess chemopreventive and chemotherapeutic properties against various types of cancer. Recent advances in understanding the molecular pathways that mediate cancer development and progression have led to an increase of interest in preclinical investigations on the mechanisms underlying anticancer activity of polyphenols. In particular, an increasing number of preclinical studies using cultured cells and animal models have demonstrated the inhibitory effects of polyphenols on tumour cell invasion and metastasis, thereby highlighting the potential of polyphenols against metastatic cancer. This review specifically addresses growing evidence of the capability of polyphenols to impair the invasion and migration of tumour cells through a diverse set of mechanisms, including downregulation of expression of matrix metalloproteinases, modulation of regulators of epithelial-mesenchymal transition, interference with Met signalling, inhibition of nuclear factor-kappa B mediated transcription, and so on. Given that metastasis occurs through a multistep process in which each step is regulated by a complex network of signalling pathways, the multi-function and multi-target characteristics of polyphenols render those promising candidates for effective adjuvant therapy against metastatic cancer.

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Polyphenols bearing cinnamaldehyde scaffold showing cell growth inhibitory effects on the cisplatin-resistant A2780/Cis ovarian cancer cells

Cited by 50 publications

References 36 publications

Flavonoids activating adenosine monophosphate-activated protein kinase

Flavonoids activating adenosine monophosphate-activated protein kinase

Quantitative Relationships Between the Cytotoxicity of Flavonoids on the Human Breast Cancer Stem‐Like Cells MCF7‐SC and Their Structural Properties

Multifaceted ability of naturally occurring polyphenols against metastatic cancer

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