Polyphenols compounds from red grapes acutely improve endothelial function in patients with coronary heart disease

Abstract

Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. These results could probably, at least partly, explain the favorable effects of red wine on the cardiovascular system.

Use of Resveratrol in Cardiovascular Diseases Prevention: A Systematic Review

“…The follow-up period ranged from 4 to 48 weeks18,19, and in spite of all the studies being randomized clinical trials, six were of the crossover type 16,18,20,22,23,26 ,and four were parallel studies 17,19,21,24 . Of the ten studies selected, six used capsules composed of resveratrol only 17,18,19,22,23,26 , in different doses (10 mg, 150 mg, 8 or 16 mg, 100mg, 30 or 90 or 270mg or 150mg respectively) and four made use of capsules mixed with different compounds 16,20,21,24 , including resveratrol.…”

“…Of the ten studies selected, six used capsules composed of resveratrol only 17,18,19,22,23,26 , in different doses (10 mg, 150 mg, 8 or 16 mg, 100mg, 30 or 90 or 270mg or 150mg respectively) and four made use of capsules mixed with different compounds 16,20,21,24 , including resveratrol. The quantity of resveratrol used in the intervention fluctuated from minimum concentrations of 0.54 mg⁄day21, to doses of 36g⁄day16.…”

“…With regard to the presence of blinding, six studies were double-blind 17,18,21,22,23 , one simple-blind…”

“…19,24 , for bias of selection. The articles that were double-blind presented low risk for bias of performance 17,18,20,21,22,23 . Of the simple-blind type, one also had low risk16, since the composition of the placebo and the substance tested was similar, the other had high risk 24 , since the composition of the placebo was different and the other had an uncertain risk 26 .…”

“…Of the simple-blind type, one also had low risk16, since the composition of the placebo and the substance tested was similar, the other had high risk 24 , since the composition of the placebo was different and the other had an uncertain risk 26 . As regards bias of detection, seven studies presented low risk 17,18,19,20,21 , and three uncertain risk 16,24,26 , since the existence of blinding or not of the researchers responsible for collection of the exams was not informed. All the studies were considered low risk for bias of loss, since the articles that presented loss during follow-up 18,20,22,23,24 , had a value lower than 20% in comparison with the beginning of randomization.…”