Polyphenols delivery by polymeric materials: challenges in cancer treatment

Vittorio, Orazio; Curcio, Manuela; Cojoc, Monica; Goya, Gerardo F.; Hampel, Silke; Iemma, Francesca; Dubrovska, Anna; Cirillo, Giuseppe

doi:10.1080/10717544.2016.1236846

Cited by 53 publications

(31 citation statements)

References 249 publications

(311 reference statements)

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“…On the other hand, when the cancer cells were treated with free drugs for 24h, antagonistic effects were observed for all the tested concentrations (CI > 1.2), becoming synergistic only after 48 h incubation with 22 µmol L −1 MTX. This is in accordance with our expectation and with literature data proving the ability of polyphenol conjugates and nanoparticle systems to increase the therapeutic efficiency of conventional anticancer drugs [16,40]. The therapeutic performance of the proposed nanoformulation, which can potentially accumulate in cancer tissues by the enhanced permeability and retention (EPR) effect, will be further investigated in suitable xenograft models, with the aim to evaluate both the pharmacokinetics profiles and the anticancer activity in vivo.…”

Section: Pharmaceuticals 2020 13 X For Peer Review 7 Of 13supporting

confidence: 89%

Dextran-Curcumin Nanoparticles as a Methotrexate Delivery Vehicle: A Step Forward in Breast Cancer Combination Therapy

et al. 2019

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With the aim to effectively deliver methotrexate (MTX) to breast cancer cells, we designed a nanocarrier system (DC) derived from the self-assembly of a dextran-curcumin conjugate prepared via enzyme chemistry with immobilized laccase acting as a solid biocatalyst. Nanoparticles consisted of homogeneously dispersed nanospheres with a mean diameter of 290 nm, as characterized by combined transmission electron microscopy and dynamic light scattering investigations. DC was able to control the MTX release overtime (t1/2 value of 310 min), with cell internalization studies proving its presence inside MCF-7 cytoplasm. Finally, improved MTX efficacy was obtained in viability assays, and attributed to the synergy of curcumin moieties and loaded MTX as underlined by a combination index (CI) < 1.

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Section: Pharmaceuticals 2020 13 X For Peer Review 7 Of 13supporting

confidence: 89%

Dextran-Curcumin Nanoparticles as a Methotrexate Delivery Vehicle: A Step Forward in Breast Cancer Combination Therapy

et al. 2019

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“…Nano-size drug particles can solve the problem and penetrate into solid tumors, due to the same nano-size property 12,13 . Therefore, along with the necessity for effective cancer therapy, high cellular uptake of NPs containing drugs may enhance the internalization of chemicals into cancer cells which leads to the improvement of anticancer efficacy 14 . In the recent years, amphiphilic copolymers with hydrophobic and hydrophilic segments have attracted considerable attention due to their unique phase behavior in the aquatic environment and potential applications for drug delivery systems [15][16][17][18] .…”

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confidence: 99%

Novel nano-vehicle for delivery and efficiency of anticancer auraptene against colon cancer cells

Jalilzadeh

Samadi

Salehi

et al. 2020

Sci Rep

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The aim of this study is to devise, prepare and characterize nano encapsulated auraptene (AUR) and evaluate cytotoxic and apoptotic effects on HT-29 colon cancer cells. Herein, AUR nano formulations were prepared by triblock (PCL-PEG-PCL) and pentablock (PLA-PCL-PEG-PCL-PLA) biodegradable copolymers in order to increase AUR bioavailability as an anticancer agent. The preparation of nano particles (NPs) was done with rotor stator homogenization (RSH) and Ultrasonic homogenization (USH) methods. The physicochemical characteristics of prepared nanoparticles (NPs) were studied using HNMR, FTIR, GPC, DLS and SEM techniques. The smaller hydrodynamic size (110 nm) and polydispersity index (PDI: 0.288) as well as higher cellular uptake (89%) were observed in PB NPs rather than TB NPs. The highest cytotoxic and apoptotic effects were observed in AUR loaded PB NPs compared to AUR loaded TB NPs and free AUR obtained by MTT assay, cell cycle arrest, Annexin V-FITC, DAPI staining and RT-PCR techniques. Real time PCR results indicated that Bax /Bcl2 expression ratio as an apoptosis predicting criterion, in free AUR, AUR loaded TB and AUR loaded PB have increased 6, 9 and 13 times, respectively (p value < 0.05). In conclusion, using biodegradable nano-vehicles for sustained delivery of natural anti-cancer compounds may open new perspectives for treatment of cancer patients. NP preparation and characterization. Nano particles size, zeta potential and morphology. Table 1 summarized the size distribution, polydispersity index and zeta potential of TB and PB NPs prepared by RSH and USH methods, measured by DLS technique. Blank PB and TB NPs size prepared by RSH method were 170 and 308 nm, while size of NPs prepared by USH method were 109.8 and 314.5 nm, respectively. PDI values of PB and TB NPs prepared by RSH method were 0.805 and 0.675 while, this value for NPs prepared by USH methods were 0.288 and 0.192, respectively (Figs. S3-S10). Surface charge of TB and PB NPs which were prepared by RSH method were −26.4 mV and −19.6 mV and for TB and PB NPs which were prepared by USH method were −17.5 mV and −9.26 mV. Due to the superiority of USH compare to RSH method in terms of smaller size, narrower PDI and lower negative surface charge, we used USH method in rest of this study. Figures 5 and 6 show the SEM images of TB and PB NPs prepared by both RSH and USH methods. As it has been seen in the SEM images revealed that NPs real size were in the range of 10 nm to 50 nm also NPs had homo-dispersed spherical morphology. Scientific RepoRtS |(2020) 10:1606 | https://doi. Auraptene release.In the current study, the release of AUR from TB and PB NPS was studied over 120 h and the controlled-release potential was assessed (Fig. 7). The release data generated in this work indicated that in pH 7.4 environment over 24 h only 16.74% and 14.29% of the drug were released from AUR loaded PB and AUR loaded TB NPs respectively. Which in pH 5.4 environment AUR release from AUR loaded PB and AUR loaded TB NPs at the same time were 14.39% and 12.76% respe...

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“…Such tunable antioxidant activity is a desirable feature for either biomedical or food applications. The ability to quench free radical species, indeed, can help in preserving the biological environment from oxidative stress, or extending the shelf‐life of foodstuffs …”

Section: Resultsmentioning

confidence: 99%

Chitosan–Quercetin Bioconjugate as Multi‐Functional Component of Antioxidants and Dual‐Responsive Hydrogel Networks

Cirillo

Curcio

Spizzirri

et al. 2019

Macro Materials & Eng

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Multifunctional hydrogels based on chitosan–quercetin (CHITQ) conjugate are prepared by a thermo‐induced radical procedure in the presence of N‐isopropylacrylamide (NIPAAm), acrylamide (AAm), and N,N′‐methylenebis(acrylamide) (MEBA). At first, quercetin (Q) is grafted onto chitosan backbone with a functionalization degree of 275 mg of Q per gram of conjugate, as calculated by 1H‐NMR analyses to impart antioxidant properties to the polysaccharide. Then, a pH and temperature sensitive hydrogel was obtained by involving CHITQ and NIPAAm in the polymerization reaction. The accessibility of phenolic moieties is modified in response to the hydrogel swelling/deswelling, as confirmed by antioxidant tests performed at different temperatures. Dual stimuli‐responsive hydrogels are proposed for the delivery of caffeine as model drug. The release profiles of caffeine depict a system particularly performing as on/off device at acidic pH with excellent applicability prospects.

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Polyphenols delivery by polymeric materials: challenges in cancer treatment

Cited by 53 publications

References 249 publications

Dextran-Curcumin Nanoparticles as a Methotrexate Delivery Vehicle: A Step Forward in Breast Cancer Combination Therapy

Dextran-Curcumin Nanoparticles as a Methotrexate Delivery Vehicle: A Step Forward in Breast Cancer Combination Therapy

Novel nano-vehicle for delivery and efficiency of anticancer auraptene against colon cancer cells

Chitosan–Quercetin Bioconjugate as Multi‐Functional Component of Antioxidants and Dual‐Responsive Hydrogel Networks

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