Polyphenols for Brain and Cognitive Health

Cox, Katherine; Scholey, Andrew

doi:10.1002/9781118883303.ch12

Cited by 6 publications

(6 citation statements)

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“…The positive changes might be attributed to the polyphenol content in GSEe. Polyphenols have been strongly associated with higher cognitive function, better mood, and protective effects against various brain diseases in literature [ 46 , 47 , 48 ]. In a study with healthy subjects, purple grape juice significantly improved reaction time on a composite attention measure and increased calm ratings when compared to placebo [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers

et al. 2021

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It is well established that maintaining healthy blood pressure is fundamental in order to avoid disorders to the heart and blood vessels. In prevention, and alongside pharmacological therapy, the use of natural substances has been proven to be extremely helpful for pre- and mild hypertensive subjects. Our study was therefore focused on the effects, both in vitro and in humans, of a grape seed extract, Enovita (GSEe), a highly standardized extract in polyphenols of Vitis vinifera L. The in vitro human umbilical vein endothelial cells (HUVEC) model was chosen to explore the extract properties related to vascular inflammation/vasodilation. A significant reduction of both soluble Inter-Cellular Adhesion Molecule-1 (sICAM) and endothelin-1 secretion/release was induced by GSEe in HUVEC cells. A randomized, double-blind, placebo-controlled clinical study in healthy volunteers was further performed to investigate GSEe benefits. In healthy volunteers, both supplementations significantly modulated blood pressure, with a pronounced effect after GSEe tablets (300 mg/day for 16 weeks) in respect to placebo. In the male gender subgroup, no placebo effect was observed as it was for the female group. As an additional outcome, an overall GSEe positive modulation emerged on mood related to stress perception. Thus, GSEe resulted in a benefit of modulating endothelial functionality and blood pressure. It was noteworthy that GSEe relieved the perceived stress, promising new future perspectives on mood comfort.

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Section: Discussionmentioning

confidence: 99%

Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers

et al. 2021

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“…It thus seems that polyphenols are molecules of interest which could have a potentially positive effect on BDNF. Epidemiological studies and randomized controlled trials have indeed shown that an elevated intake of polyphenols can be linked to neuroprotective effects associated with improved cognitive function [66]. Based on polyphenols' chemical structure, they can be classified into flavonoids, phenolic acids, stilbenes, lignans, and other phenolic compounds [67].…”

Section: Discussionmentioning

confidence: 99%

Effects of nutritional interventions on BDNF concentrations in humans: a systematic review

Gravesteijn

Mensink

2021

Nutritional Neuroscience

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“…However, effects on fasting glycaemia were mixed and no studies to date have examined the anti-inflammatory effects of these extracts in humans 18. Furthermore, a recent chapter by Cox and Scholey indicated that polyphenols from terrestrial sources (eg, tea, cocoa) had positive impacts on mood and cognition, however, no studies to date have examined the long-term impact of a polyphenol-rich brown seaweed extract on these outcomes 39…”

Section: Discussionmentioning

confidence: 99%

“…A further novel aspect of this study will be the investigation of the effects of a polyphenol-rich brown seaweed extract on cognitive function and mood. The brain is a highly metabolically active organ making it susceptible to oxidative stress, inflammatory processes and fluctuations in blood flow and vascular processes 39. Management of these processes involves multiple biological systems which are influenced by dietary intake, including polyphenols.…”

Section: Introductionmentioning

confidence: 99%

Study protocol for a double-blind randomised controlled trial investigating the impact of 12 weeks supplementation with aFucus vesiculosusextract on cholesterol levels in adults with elevated fasting LDL cholesterol who are overweight or have obesity

et al. 2018

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IntroductionHyperlipidaemia, hyperglycaemia and chronic inflammation are risk factors for chronic diseases cardiovascular disease and type 2 diabetes. Polyphenols are bioactive compounds found in marine algae with potential antihyperlipidaemic, antihyperglycaemic and anti-inflammatory effects. The modulation of these risk factors using bioactive polyphenols may represent a useful strategy for disease prevention and management; research in humans, however, remains limited. This trial aims to determine the impact of a polyphenol-rich brown seaweed extract on fasting hyperlipidaemia, hyperglycaemia and inflammation. Effects on mood and cognition will also be evaluated.Methods and analysisFifty-eight hypercholesterolaemic participants who are overweight or have obesity will be randomised to receive either a polyphenol-rich brown seaweed extract (2000 mg dose containing 600 mg polyphenols) or placebo (2000 mg rice flour) daily for 12 weeks. Fasting venous blood samples will be taken at baseline, week 6 and week 12 of the intervention to assess serum cholesterol (total, low-density lipoprotein and high-density lipoprotein) and triglyceride concentrations, plasma glucose and insulin concentrations and markers of inflammation. Mood and cognitive function will be evaluated as exploratory outcomes. Independent t-tests or equivalent will be used to determine differences between the two groups in changes from baseline to week 12. Analysis of variance will be used to assess differences between the groups across the three time points (baseline, week 6 and week 12).Ethics and disseminationEthics approval has been granted by the Monash University Human Research Ethics Committee (2017-8689-10379). Results from this trial will be disseminated through publication in peer-reviewed journals, national and international presentations, and a PhD thesis. These results are essential to inform the use of polyphenol-rich brown seaweeds as a functional food or nutritional supplement ingredients for health promotion and disease prevention and management in humans.Trial registration numberACTRN12617001039370; Pre-results.

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Polyphenols for Brain and Cognitive Health

Cited by 6 publications

References 87 publications

Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers

Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers

Effects of nutritional interventions on BDNF concentrations in humans: a systematic review

Study protocol for a double-blind randomised controlled trial investigating the impact of 12 weeks supplementation with aFucus vesiculosusextract on cholesterol levels in adults with elevated fasting LDL cholesterol who are overweight or have obesity

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