Polyphenols from Brown Seaweeds (Ochrophyta, Phaeophyceae): Phlorotannins in the Pursuit of Natural Alternatives to Tackle Neurodegeneration

Barbosa, Mariana; Valentão, Patrı́cia; Andrade, Paula B.

doi:10.3390/md18120654

Cited by 22 publications

(24 citation statements)

References 105 publications

(213 reference statements)

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“…A growing number of studies have indicated the bioactive potential of phlorotannins in regard to neuroprotection via antioxidant and anti‐neuroinflammatory properties, in addition to some reported anti‐aggregatory activity vs. amyloid β (Ahn et al ., 2012; Wang et al ., 2018; Lee et al ., 2019; Barbosa et al ., 2020; Shrestha et al ., 2021b). Overall, this study suggests that while diverse phlorotannins more broadly share free radical scavenging and antioxidant neuroprotective properties, not all phlorotannin classes provide discreet protection against amyloid β‐evoked neurotoxicity.…”

Section: Discussionmentioning

confidence: 99%

“…These brown algae (Phaeophyta) synthesise a variety of phloroglucinol‐based polyphenols as phlorotannins. Phlorotannins have been previously demonstrated to have neuroprotective activity via various modes of action including inhibition of acetylcholinesterase, butyrylcholinesterase, monoamine oxidase and beta‐site amyloid precursor protein cleaving enzyme 1 (BACE‐1) activity (Barbosa et al ., 2020). Phlorotannins can also modulate neuronal receptors and regulate signalling pathways linked to neuroinflammation, oxidative stress and neuronal cell death (Barbosa et al ., 2020; Shrestha et al ., 2021b).…”

Section: Introductionmentioning

confidence: 99%

“…Phlorotannins have been previously demonstrated to have neuroprotective activity via various modes of action including inhibition of acetylcholinesterase, butyrylcholinesterase, monoamine oxidase and beta‐site amyloid precursor protein cleaving enzyme 1 (BACE‐1) activity (Barbosa et al ., 2020). Phlorotannins can also modulate neuronal receptors and regulate signalling pathways linked to neuroinflammation, oxidative stress and neuronal cell death (Barbosa et al ., 2020; Shrestha et al ., 2021b). Previous studies have shown that eckol, dieckol and phlorofucofuroeckol A (PFFA) decreased Aβ‐induced cell death, inhibited intracellular ROS generation and calcium generation (Ahn et al ., 2012), while Lee et al .…”

Section: Introductionmentioning

confidence: 99%

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Neuroprotective activity of macroalgal fucofuroeckols against amyloid β peptide‐induced cell death and oxidative stress

Shrestha

Choi

Zhang

et al. 2022

Int J of Food Sci Tech

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Summary Phlorotannins are polyphenolic compounds predominantly found in brown seaweeds tentatively identified as having neuroprotective bioactivity; however, the effects of individual constituent phlorotannins against amyloid β neurotoxicity, the main hallmark neurotoxic protein in Alzheimer’s disease (AD), is yet to be fully characterised. In this study, four phlorotannins, namely eckol, dieckol, phlorofucofuroeckol‐A (PFFA) and 974‐A sourced from the brown seaweed Ecklonia species were assessed for their ability to protect against the toxic effects of H2O2, lipid peroxidation via tert‐butyl hydroperoxide (t‐BHP) and Aβ1–42 in neuronal PC12 cells. All compounds significantly scavenged reactive oxygen species (ROS). However, only PFFA and 974‐A protected PC12 cells from oxidative stress‐evoked neurotoxicity, providing significant increases in cell viability in response to both cytosolic (H2O2) and lipid peroxidation‐evoked (t‐BHP) cell stress. None of the phlorotannins tested inhibited Aβ1–42 aggregate morphology, which suggested that their neuroprotective activity was unrelated to direct interactions with Aβ1–42 protein. Our results indicate that while all phlorotannins tested exhibited ROS scavenging activity, only fucofuroeckol‐type phlorotannins such as PFFA and 974‐A afforded broader neuroprotective activity in response to both oxidative stress and amyloid β exposure. The additional amyloid‐protective capacity of fucofuroeckols reveals the potential importance of the benzofuran moiety in neuroprotection and further studies are encouraged to investigate the chemico‐biological basis of this distinction in the search for neuroprotective therapies in dementia and other neurodegenerative conditions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neuroprotective activity of macroalgal fucofuroeckols against amyloid β peptide‐induced cell death and oxidative stress

Shrestha

Choi

Zhang

et al. 2022

Int J of Food Sci Tech

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“…Marine algae-derived polyphenols have been investigated for their photo protective activities. Phlorotannins, as dieckol, phloroglucinol, fucofuroeckol-A, and triphlorethol-A, isolated from marine brown algae, exhibited prominent protective effect against photo damage, induced by UVB radiation [50,51]. Thring et al determined anti-collagenase, anti-elastase, and antioxidant activities of 21 plant extracts and correlated them with the total phenolic content.…”

Section: Polyphenols: Anti-senescence Nutraceuticalsmentioning

confidence: 99%

Impact of Polyphenolic-Food on Longevity: An Elixir of Life. An Overview

Meccariello

D’Angelo

2021

Antioxidants

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Aging and, particularly, the onset of age-related diseases are associated with tissue dysfunction and macromolecular damage, some of which can be attributed to accumulation of oxidative damage. Recently, growing interest has emerged on the beneficial effects of plant-based diets for the prevention of chronic diseases including obesity, diabetes, and cardiovascular disease. Several studies collectively suggests that the intake of polyphenols and their major food sources may exert beneficial effects on improving insulin resistance and related diabetes risk factors, such as inflammation and oxidative stress. They are the most abundant antioxidants in the diet, and their intake has been associated with a reduced aging in humans. Polyphenolic intake has been shown to be effective at ameliorating several age-related phenotypes, including oxidative stress, inflammation, impaired proteostasis, and cellular senescence, both in vitro and in vivo. In this paper, effects of these phytochemicals (either pure forms or polyphenolic-food) are reviewed and summarized according to affected cellular signaling pathways. Finally, the effectiveness of the anti-aging preventive action of nutritional interventions based on diets rich in polyphenolic food, such as the diets of the Blue zones, are discussed.

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“…In the context of multifunctional ligand therapy, marine and terrestrial organisms are a fundamental source for the discovery of new bioactive agents [ 24 , 25 , 26 , 27 , 28 ]. In the last few years, several different compounds isolated from plants and microorganisms have shown good effects for the treatment of AD and several drug candidates are in clinical trials, confirming that the use of natural compounds against AD is an active and interesting area of research [ 23 , 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Small Molecules as Potential Anti-Alzheimer’s Disease Agents

et al. 2021

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Alzheimer’s disease (AD) is a severe multifactorial neurodegenerative disorder characterized by a progressive loss of neurons in the brain. Despite research efforts, the pathogenesis and mechanism of AD progression are not yet completely understood. There are only a few symptomatic drugs approved for the treatment of AD. The multifactorial character of AD suggests that it is important to develop molecules able to target the numerous pathological mechanisms associated with the disease. Thus, in the context of the worldwide recognized interest of multifunctional ligand therapy, we report herein the synthesis, characterization, physicochemical and biological evaluation of a set of five (1a–e) new ferulic acid-based hybrid compounds, namely feroyl-benzyloxyamidic derivatives enclosing different substituent groups, as potential anti-Alzheimer’s disease agents. These hybrids can keep both the radical scavenging activity and metal chelation capacity of the naturally occurring ferulic acid scaffold, presenting also good/mild capacity for inhibition of self-Aβ aggregation and fairly good inhibition of Cu-induced Aβ aggregation. The predicted pharmacokinetic properties point towards good absorption, comparable to known oral drugs.

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Polyphenols from Brown Seaweeds (Ochrophyta, Phaeophyceae): Phlorotannins in the Pursuit of Natural Alternatives to Tackle Neurodegeneration

Cited by 22 publications

References 105 publications

Neuroprotective activity of macroalgal fucofuroeckols against amyloid β peptide‐induced cell death and oxidative stress

Neuroprotective activity of macroalgal fucofuroeckols against amyloid β peptide‐induced cell death and oxidative stress

Impact of Polyphenolic-Food on Longevity: An Elixir of Life. An Overview

Multifunctional Small Molecules as Potential Anti-Alzheimer’s Disease Agents

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