Polyphenols inhibiting MAPK signalling pathway mediated oxidative stress and inflammation in depression

Behl, Tapan; Rana, Tarapati; Alotaibi, Ghallab; Shamsuzzaman, Md.; Naqvi, Maaz; Sehgal, Aayush; Singh, Sukhbir; Sharma, Neelam; Almoshari, Yosif; Abdellatif, Ahmed A.H.; Iqbal, Muhammad Shahid; Bhatia, Saurabh; Al‐Harrasi, Ahmed; Bungău, Simona

doi:10.1016/j.biopha.2021.112545

Cited by 118 publications

(45 citation statements)

References 177 publications

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“…In addition, we found that miR-1202, which has consistently been reported to be associated with treatment response to antidepressants using the candidate approach [ 46 , 50 ], was also correlated with treatment response based on our genome-wide approach. In silico pathway analysis enabled us to identify 21 pathways associated with the 228 miRNAs and their interacting genes such as TGFBR2, TNF, MAPK, SMAD, including the TGF-β, glutamatergic synapse, and long-term depression pathways, associated with major depressive disorder, as well as the MAPK signaling pathway reported in previous studies [ 30 , 59 , 63 , 64 , 65 , 66 , 67 , 68 ]. Although preliminary, the findings of this study indicate that these miRNAs could be used to predict groups with the highest and least likelihood of antidepressant response at 2 weeks.…”

Section: Discussionmentioning

confidence: 99%

Multiple Pre-Treatment miRNAs Levels in Untreated Major Depressive Disorder Patients Predict Early Response to Antidepressants and Interact with Key Pathways

Kato

Ogata

Tahara

et al. 2022

IJMS

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Major depressive disorder (MDD) is a life-impairing disorder, and early successful treatment is important for a favorable prognosis. However, early response to antidepressants differs widely among individuals, and is difficult to predict pre-treatment. As miRNAs have been reported to play important roles in depression, identification of miRNAs associated with antidepressant treatment responses and their interacting genes and pathways will be beneficial in understanding the predictors and molecular mechanisms of depression treatment. This randomized control trial examined miRNAs correlated with the early therapeutic effect of selective serotonin reuptake inhibitors (SSRIs; paroxetine or sertraline) and mirtazapine monotherapy. Before medication, we comprehensively analyzed the miRNA expression of 92 depressed participants and identified genes and pathways interacting with miRNAs. A total of 228 miRNAs were significantly correlated with depressive symptoms improvements after 2 weeks of SSRIs treatment, with miR-483.5p showing the most robust correlation. These miRNAs are involved in 21 pathways, including TGF-β, glutamatergic synapse, long-term depression, and the mitogen-activated protein kinase (MAPK) signaling pathways. Using these miRNAs enabled us to predict SSRI response at week 2 with a 57% difference. This study shows that pre-treatment levels of miRNAs could be used to predict early responses to antidepressant administration, a knowledge of genes, and an identification of genes and pathways associated with the antidepressant response.

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Section: Discussionmentioning

confidence: 99%

Multiple Pre-Treatment miRNAs Levels in Untreated Major Depressive Disorder Patients Predict Early Response to Antidepressants and Interact with Key Pathways

Kato

Ogata

Tahara

et al. 2022

IJMS

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“…The polyphenols may be responsible for the antioxidant activities observed in the present study. Polyphenols are a class of compounds with various biological activities, including antibacterial activity, antioxidant, and anti-inflammatory activities, among others [ 41 , 42 ]. Additionally, the unsaturated fatty acids in emu oil would scarcely react with free radicals [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Chemical Characterization and In Vivo Toxicological Safety Evaluation of Emu Oil

Lan

Luo

et al. 2022

Nutrients

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In this study, the physicochemical properties, fatty acid composition, antioxidant activities, and in vitro as well as in vivo toxicological safety of emu oil were investigated. Emu oil was shown to have a low acid and peroxide value, low amounts of carotenoid and phenolic compounds, and high doses of oleic acid and linoleic acid. Furthermore, in a bacterial reverse mutation assay, emu oil demonstrated no change in the amount of revertant colonies for all strains. In a chromosomal assay, no aberrations occurred in any of the emu oil treatment groups (1.25, 2.5, and 5 μg/mL). In the bone marrow micronucleus test, emu oil up to 20 mL/kg showed no significant increase in the incidence of micronucleated polychromatic erythrocytes. Moreover, emu oil up to 19.3 mg/kg body weight did not affect body weight in an acute oral toxicity study. These results are crucial for the adoption of emu oil as an alternative source of edible oil.

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“…The anti-inflammatory effects of polyphenols on APCs are implemented by diverse mechanisms ( Figure 4 ). Inflammatory stimuli, e.g., TLR4 engagement, trigger the overproduction of ROS, that promote activation of NF-кB, MAPK, and PI3K/Akt-mediated pathways and gene expression of pro-inflammatory cytokines, whereas polyphenols reduce ROS generation [ 183 ]. Multiple polyphenols inhibit phosphorylation and the degradation of the inhibitor of NF-κB (IκB) and/or phosphorylation of IKK (IκB kinase), due to their antioxidant properties [ 182 ].…”

Section: Cholesterol Lowering Dietary Compoundsmentioning

confidence: 99%

“…Resveratrol upregulates activity of SIRT1, a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, that also induces the hypoacetylation of RelA [ 186 ]. Polyphenols inhibit formation of NLRP3-inflammasome and thereby reduce IL-1β production in APCs [ 183 , 184 , 185 ]. Furthermore, polyphenols act as the natural ligands of nuclear factor erythroid 2-related factor 2 (NRF2), that negatively regulates the gene expression of pro-inflammatory cytokines [ 183 , 184 , 185 ].…”

Section: Cholesterol Lowering Dietary Compoundsmentioning

confidence: 99%

The Impacts of Cholesterol, Oxysterols, and Cholesterol Lowering Dietary Compounds on the Immune System

Yanagisawa

Asai

et al. 2022

IJMS

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Cholesterol and its oxidized forms, oxysterols, are ingested from foods and are synthesized de novo. Cholesterol and oxysterols influence molecular and cellular events and subsequent biological responses of immune cells. The amount of dietary cholesterol influence on the levels of LDL cholesterol and blood oxysterols plays a significant role in the induction of pro-inflammatory state in immune cells, leading to inflammatory disorders, including cardiovascular disease. Cholesterol and oxysterols synthesized de novo in immune cells and stroma cells are involved in immune homeostasis, which may also be influenced by an excess intake of dietary cholesterol. Dietary compounds such as β-glucan, plant sterols/stanols, omega-3 lipids, polyphenols, and soy proteins, could lower blood cholesterol levels by interfering with cholesterol absorption and metabolism. Such dietary compounds also have potential to exert immune modulation through diverse mechanisms. This review addresses current knowledge about the impact of dietary-derived and de novo synthesized cholesterol and oxysterols on the immune system. Possible immunomodulatory mechanisms elicited by cholesterol-lowering dietary compounds are also discussed.

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Polyphenols inhibiting MAPK signalling pathway mediated oxidative stress and inflammation in depression

Cited by 118 publications

References 177 publications

Multiple Pre-Treatment miRNAs Levels in Untreated Major Depressive Disorder Patients Predict Early Response to Antidepressants and Interact with Key Pathways

Multiple Pre-Treatment miRNAs Levels in Untreated Major Depressive Disorder Patients Predict Early Response to Antidepressants and Interact with Key Pathways

Chemical Characterization and In Vivo Toxicological Safety Evaluation of Emu Oil

The Impacts of Cholesterol, Oxysterols, and Cholesterol Lowering Dietary Compounds on the Immune System

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