Polyphenols: Natural Preservatives with Promising Applications in Food, Cosmetics and Pharma Industries; Problems and Toxicity Associated with Synthetic Preservatives; Impact of Misleading Advertisements; Recent Trends in Preservation and Legislation

Abstract

The global market of food, cosmetics, and pharmaceutical products requires continuous tracking of harmful ingredients and microbial contamination for the sake of the safety of both products and consumers as these products greatly dominate the consumer’s health, directly or indirectly. The existence, survival, and growth of microorganisms in the product may lead to physicochemical degradation or spoilage and may infect the consumer at another end. It has become a challenge for industries to produce a product that is safe, self-stable, and has high nutritional value, as many factors such as physical, chemical, enzymatic, or microbial activities are responsible for causing spoilage to the product within the due course of time. Thus, preservatives are added to retain the virtue of the product to ensure its safety for the consumer. Nowadays, the use of synthetic/artificial preservatives has become common and has not been widely accepted by consumers as they are aware of the fact that exposure to preservatives can lead to adverse effects on health, which is a major area of concern for researchers. Naturally occurring phenolic compounds appear to be extensively used as bio-preservatives to prolong the shelf life of the finished product. Based on the convincing shreds of evidence reported in the literature, it is suggested that phenolic compounds and their derivatives have massive potential to be investigated for the development of new moieties and are proven to be promising drug molecules. The objective of this article is to provide an overview of the significant role of phenolic compounds and their derivatives in the preservation of perishable products from microbial attack due to their exclusive antioxidant and free radical scavenging properties and the problems associated with the use of synthetic preservatives in pharmaceutical products. This article also analyzes the recent trends in preservation along with technical norms that regulate the food, cosmetic, and pharmaceutical products in the developing countries.

Dose-response analysis for the effects of Coffea arabica L. on growth performance, health status, and economic efficiency of fattened rabbits raised under high ambient temperature

“…Moreover, the significant decrease in the levels of urea and creatinine concentrations in serum of GC treated rabbits compared to control indicated a potential and positive impact of dietary GC supplementation on normal kidney function and feed utilization. Many phenolic compounds of GC have hepatoprotective effect mainly through their antioxidant, anti-inflammatory and detoxification activities (Rathee et al, 2023).…”

A review on the chemical ecology of the Fucaceae holobionts: from fundamental knowledge to applications

“…For instance, some synthetic preservatives such as parabens are controversial. They are suspected to cause skin sensitization, allergic dermatitis, as well as estrogenic and carcinogenic effects (breast cancer and malignant melanoma) [44]. Due to their antifungal and antibacterial activities, phenolic compounds of Fucaceae are promising alternatives as natural cosmetics preservatives [40,45].…”

Evaluation of the effectiveness of natural extract as a substituent for synthetic preservatives and antioxidants in pharmaceutical preparations

“…Several studies showed that the usage of synthetic antimicrobial agents in pharmaceutical products was associated with many toxic effects on human health, such as ocular toxicity, genotoxicity, and bacterial resistance ( Goto et al, 2003 , Breitkreutz and Boos, 2007 , Shehab et al, 2009 , Kaur et al, 2009 , Sarkar, 2021 ). Therefore, the usage of natural preservatives as an alternative to synthetic preservatives considering their effectiveness and safety, is a promising trend in many industries, such as foods, cosmetics, and pharma ( Rathee et al, 2023 ).…”