Polyphenols with Antiulcerogenic Action from Aqueous Decoction of Mango Leaves (Mangifera indica L.)

Severi, Juliana Aparecida; Lima, Zeila Pinheiro; Kushima, Hélio; Brito, Alba Regina Monteiro Souza; Santos, Lourdes Campaner dos; Vilegas, Wagner; Hiruma-Lima, Clélia Akiko

doi:10.3390/molecules14031098

Cited by 80 publications

(52 citation statements)

References 56 publications

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“…Considering the individual plant components of DAS-77, Severi et al [25] reported the gastroprotective effect of the aqueous decoction of Mangifera indica leaves in several ulcer models in rats. Phenolic compounds consequently isolated from the extract include mangiferin and cglucosylbenzophenone.…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective Effects of DAS-77 (a Phytomedicine) in Ulcer Models in Rats

Akindele¹,

Aigbe²,

Olowe³

et al. 2013

Trop. J. Pharm Res

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Purpose: DAS-77 is a phytomedicine that contains the dried bark of Mangifera indica and root of Carica papaya. This study investigated the antiulcer effects of DAS-77 in rats. Methods: DAS-77 was administered orally twice daily for five consecutive days at doses of 50 -400 mg/kg. Ulcer was induced in rats with ethanol, indomethacin, pylorus ligation (PL) and cold restraint stress (CRS). Ulcer scores were recorded based on examination of excised stomachs. Estimations of gastric content volume, pH and titratable acidity in the PL model and determination of the levels of antioxidants and malondialdehyde (MDA) in gastric tissues in the CRS model were also done. Results: In all the models, DAS-77 produced significant dose-dependent reductions in ulcer score. Peak effects were produced at the dose of 400 mg/kg with ulcer inhibition values of 98.57, 76.23, 99.28 and 96.70 % compared to 100.00, 93.79, 98.92 and 96.79 % for misoprostol/cimetidine, respectively, for the ethanol, indomethacin, PL and CRS models. In the PL model, DAS-77 caused a significant increase in pH of gastric content but a reduction in volume and titratable acidity. At doses of 50 and 100 mg/kg in the CRS model, DAS-77 significantly increased the level of reduced glutathione (GSH) and diminished MDA. Conclusion:The results obtained in this study suggest that DAS-77 possesses gastroprotective activity possibly due to reduced gastric secretion and acidity, and antioxidant activity.

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Section: Discussionmentioning

confidence: 99%

Gastroprotective Effects of DAS-77 (a Phytomedicine) in Ulcer Models in Rats

Akindele¹,

Aigbe²,

Olowe³

et al. 2013

Trop. J. Pharm Res

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“…Many evidence support that mango also possesses gastro-protective effects. To this purpose, Severi et al [23] showed that a Mangifera indica leaf decoction attenuated in mice the gastric damage induced by HCl/ethanol. This effect seems to be related to mangiferin and benzophenone glycoside, the main bioactive molecules present in leaf decoction.…”

Section: Anti-inflammatory Effects Of Mangomentioning

confidence: 99%

Multifaceted Healthy Benefits of <em>Mangifera Indica</em> L. (Mango): The Inestimable Value of an Orchard Recently Rooted in Sicilian Rural Areas

Lauricella¹,

Emanuele²,

Calvaruso³

et al. 2017

Preprint

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Abstract:Historically, Mangifera indica L. cultivations have been widely rooted in tropical areas of India, Africa, Asia and Central America. However, at least 20 years ago its spreading allowed the development of some cultivars, also in Sicily, the South of Italy, where the favorable subtropical climate and adapted soils represent the perfect field to create new sources of production for Sicilian agricultural supply chain. Currently, cultivations of Kensington Pride, Keitt, Klenn, Maya and Tommy Atkins varieties are active in Sicilian island and their products meet the requirements of local and European markets. Mango plants produce fleshy stone fruits rich in phytochemicals with an undisputed nutritional value for its high content of flavonoids, vitamins, micro-and macro-elements, vital for maintaining health. This review provides an overview of the antioxidant, anti-inflammatory and anticancer properties of Mango, a fruit that should be included in everyone's diet for its multifaceted biochemical actions and nutraceutical potential.

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“…13 Two main phenolic compounds were isolated from M. indica leaves aqueous decoction, specifically mangiferin and C-glucosylbenzophenone. 14 Six different extracts from the leaves of Mangifera indica was extracted. In that study, a hexane-ethyl acetate extract was characterized by gas chromatography-mass spectroscopy.…”

Section: Introductionmentioning

confidence: 99%

In vitro Antioxidant Activities of Aqueous and Ethanol Extracts of Mangifera indica Leaf, Stem-Bark and Root-Bark

Udem¹,

Dahiru²,

Etteh³

2018

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Introduction: Mangifera indica is a rampant Nigerian plant with history of application in traditional medicine for the treatment of degenerative diseases by indigenous Nigerians. Methods: The leaf, stem-bark and root-bark of M. indica were screened for phytoconstituents. The dried powdered plant parts were extracted using aqueous and ethanol solvents. The antioxidant activity of the concentrated extracts was determined using the ferric reducing anti-oxidant power (FRAP), 2, 2'-diphenyl-1-picrylhydrazyl (DPPH) and thiobarbi-turic acid reactive substance (TBARS) assay methods. Result: The results obtained were analysed statistically by one -way analysis of variance with level of statistical significance taken as p<0.05. In FRAP assay, leaf and stem-bark aqueous extracts showed the highest antioxidant activity with values 92.75 ± 0.48% and 94.49 ± 0.48% respectively while the root-bark ethanol extract (68.67 ± 1.49%) showed the highest activity. In DPPH assay, the leaf, stem-bark and root-bark ethanol extracts showed the best percentage DPPH scavenging activity with values 79.09 ± 0.42%, 59.86 ± 0.32% and 80.70 ± 0.42% respectively. In TBARS assay, the leaf and root-bark aqueous extracts showed the best activities with values 97.75 ± 0.56% and 99.48 ± 0.33% and the stem-bark ethanol extract (99.62 ± 0.26%). Conclusion: The study shows that both the aqueous and ethanol extracts of M. indica could be useful to combat free radical mediated diseases.Key words: Mangifera indica leaf, 2,2'-diphenyl-1-picrylhydrazyl (DPPH), Thiobarbituric acid reactive substance (TBARS), Stem-Bark, Root-Bark, Antioxidant activity. Correspondence INTRODUCTIONRecently, antioxidant activity (AOA) has been used as a parameter to characterize various products' health-enhancing properties. This is connected with a common opinion on antioxidants' crucial role in the prevention of oxidative stress 1 related diseases and on the reduction of total mortality, 2-3 associated with diets rich in plant foods, particularly fruits and vegetables. 4 In most areas of food manufacturing, precise knowledge of antioxidant capacity (AOC) is becoming of great importance; thus many analytical methods and measuring systems have been developed. Certain antioxidants or reactions are method-specific, so researchers don't just depend on a particular method only, but employ several others for determining the AOC of fruits and vegetables. 5 Cancer prevention with the aid of bioactive fractions as well as with specific phytochemical obtained from plants with proof of cancer-inhibiting properties pose promising alternatives to the present cancer drugs. [6][7] Antioxidant compounds have been widely used to reduce clinical toxicity 8 induced by cancer drugs in patients; there is yet to be any observed reduction in these drugs' efficacy. From time immemorial, plants have been used as a source for drug compounds, and plant derived medicines have made large contributions to human health and wellbeing. 10 Many plants known to possess antioxidant properties have been pr...

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Polyphenols with Antiulcerogenic Action from Aqueous Decoction of Mango Leaves (Mangifera indica L.)

Cited by 80 publications

References 56 publications

Gastroprotective Effects of DAS-77 (a Phytomedicine) in Ulcer Models in Rats

Gastroprotective Effects of DAS-77 (a Phytomedicine) in Ulcer Models in Rats

Multifaceted Healthy Benefits of <em>Mangifera Indica</em> L. (Mango): The Inestimable Value of an Orchard Recently Rooted in Sicilian Rural Areas

In vitro Antioxidant Activities of Aqueous and Ethanol Extracts of Mangifera indica Leaf, Stem-Bark and Root-Bark

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