Polyphosphate coated nanoparticles: Enzyme-activated charge-reversal gene delivery systems

Akkuş-Dağdeviren, Zeynep Burcu; Arısoy, Sema; Friedl, Julian David; Fürst, Andrea; Saleh, Ahmad; Bernkop-Schnürch, Andreas

doi:10.1016/j.ijpharm.2023.123474

International Journal of Pharmaceutics

2023

DOI: 10.1016/j.ijpharm.2023.123474

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Polyphosphate coated nanoparticles: Enzyme-activated charge-reversal gene delivery systems

Zeynep Burcu Akkuş-Dağdeviren,

Sema Arısoy,

Julian David Friedl

et al.

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Cited by 3 publications

References 62 publications

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Controlled lipid digestion in the development of functional and personalized foods for a tailored delivery of dietary fats

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Controlled lipid digestion in the development of functional and personalized foods for a tailored delivery of dietary fats

Kupikowska-Stobba,

Niu,

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et al. 2025

Food Chemistry

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The power of sulfhydryl groups: Thiolated lipid-based nanoparticles enhance cellular uptake of nucleic acids

Stengel,

Jörgensen,

Polidori

et al. 2024

Journal of Colloid and Interface Science

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Charge-Reversal Nano-Drug Delivery Systems in the Tumor Microenvironment: Mechanisms, Challenges, and Therapeutic Applications

Liang,

Wu,

Yan

et al. 2024

IJMS

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The charge-reversal nano-drug delivery system (CRNDDS) is a promising system for delivering chemotherapy drugs and has gained widespread application in cancer treatment. In this review, we summarize the recent advancements in CRNDDSs in terms of cancer treatment. We also delve into the charge-reversal mechanism of the CRNDDSs, focusing on the acid-responsive, redox-responsive, and enzyme-responsive mechanisms. This study elucidates how these systems undergo charge transitions in response to specific microenvironmental stimuli commonly found in tumor tissues. Furthermore, this review explores the pivotal role of CRNDDSs in tumor diagnosis and treatment, and their potential limitations. By leveraging the unique physiological characteristics of tumors, such as the acidic pH, specific redox potential, and specific enzyme activity, these systems demonstrate enhanced accumulation and penetration at tumor sites, resulting in improved therapeutic efficacy and diagnostic accuracy. The implications of this review highlight the potential of charge-reversal drug delivery systems as a novel and targeted strategy for cancer therapy and diagnosis.

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Polyphosphate coated nanoparticles: Enzyme-activated charge-reversal gene delivery systems

Cited by 3 publications

References 62 publications

Controlled lipid digestion in the development of functional and personalized foods for a tailored delivery of dietary fats

Controlled lipid digestion in the development of functional and personalized foods for a tailored delivery of dietary fats

The power of sulfhydryl groups: Thiolated lipid-based nanoparticles enhance cellular uptake of nucleic acids

Charge-Reversal Nano-Drug Delivery Systems in the Tumor Microenvironment: Mechanisms, Challenges, and Therapeutic Applications

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