Polyphosphazene polymers: The next generation of biomaterials for regenerative engineering and therapeutic drug delivery

Ogueri, Kenneth S.; Ogueri, Kennedy S.; Allcock, Harry R.; Laurencin, Cato T.

doi:10.1116/6.0000055

Cited by 34 publications

(58 citation statements)

References 93 publications

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“…d, H & E-stained section illustrating the in vivo biocompatibility of the PZ-PLGA. The histological image is also demonstrating the formation of polymer spheres with pore system and collagen tissue infiltration within the pores (Deng, Nair, Nukavarapu, Kumbar, et al, 2010) 2018; Ogueri et al, 2020a;Ogueri et al, 2020b;Zhou et al, 2020).…”

Section: F I G U R Ementioning

confidence: 96%

“…The biomedical research on polyphosphazenes has garnered relatively considerable interest, especially in bone regenerative engineering and drug delivery (Allcock, 2016;Allcock & Morozowich, 2012;Baillargeon & Mequanint, 2014;Ni et al, 2020;. One of the most intriguing parts of macromolecular substitution reaction is its variability that allows the incorporation of several biologically relevant groups onto the skeletal backbone of polyphosphazenes (Ogueri et al, 2020a).…”

Section: B I Omed I C Al a S Pec Ts And Implic Ationsmentioning

confidence: 99%

“…Hence, polyphosphazenes can possess immobilization capabilities and tend to degrade to release the immobilized molecules, which can have therapeutic effects (Figure 2; Ni et al, 2020;Ogueri et al, 2020a;Strasser & Teasdale, 2020).…”

Section: B I Omed I C Al a S Pec Ts And Implic Ationsmentioning

confidence: 99%

“…Interestingly, polyphosphazenes offer the dynamism to personalize and adapt the nanofibre properties to precisely meet the needs of intended applications. Polyphosphazene nanofibres have shown excellent prospects as a carrier matrix for controlling and sustaining therapeutic drug release (Deng et al, 2011;Ogueri et al, 2020a). Currently, there is increasing interest in the utility of polyphosphazene in nanolayer device surface modification (Bates, Yousaf, Sun, Barakat, & Kueller, 2019;L.-C. Xu et al, 2018;L.…”

Section: F I G U R Ementioning

confidence: 99%

“…For example, Deng et al (Deng et al, 2011) (Allcock, 2018;Ogueri, Escobar Ivirico, et al, 2019). These stringent conditions pose a formidable hurdle to the manufacturing process development and scale-up (Ogueri et al, 2020a). Additionally, the properties of a linear polyphosphazene can sometimes be problematic to control due to its high molecular weight and broad molecular weight distribution (Ogueri et al, , 2020a.…”

Section: F I G U R Ementioning

confidence: 99%

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Biomedical applications of polyphosphazenes

Ogueri

Ude

et al. 2020

Med Devices & Sens

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Although numerous conventional organic polymers have been utilized in biomedical applications, a few numbers of them have had expected and desired success for essential medical use such as scaffolding materials for regenerative engineering, controlled drug delivery systems, and surgical sutures (Ogueri, Jafari, Ivirico, & Laurencin, 2019). This is because most organic polymers (with few exceptions) lack the design flexibility and property tunability as materials scientist and engineers often focus on harnessing and optimizing the physicochemical properties of polymers during design, scale-up, and commercialization (Ogueri, Ivirico, Nair, Allcock,

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Section: F I G U R Ementioning

confidence: 96%

Section: B I Omed I C Al a S Pec Ts And Implic Ationsmentioning

confidence: 99%

Section: B I Omed I C Al a S Pec Ts And Implic Ationsmentioning

confidence: 99%

Section: F I G U R Ementioning

confidence: 99%

Section: F I G U R Ementioning

confidence: 99%

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Biomedical applications of polyphosphazenes

Ogueri

Ude

et al. 2020

Med Devices & Sens

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Phosphazene Tripeptide Conjugates: Design, Synthesis, In Vitro Cytotoxicity and Genotoxicity, Molecular Interactions in Binding Pockets on Human Breast and Colon Cancer Cell Lines

Çalışkan,

Yüksel,

Çapan

et al. 2024

ChemMedChem

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The biological activity of both cyclophosphazenes and peptides makes these compounds important for new studies in medicinal chemistry. For this purpose, five different phosphazene‐peptide conjugates synthesized from dichlorocyclotriphosphazene and tyrosine‐containing tripeptides. The synthesized compounds were evaluated for their in vitro cytotoxic activities against human breast (MCF‐7) and colon (Caco‐2) cancer cell lines using MTT assay. The derivatives induced cell death through DNA damage, with notable effects in Caco‐2 cell lines. Specifically, DTVV, DTVG, and DTVA were cytotoxic at 50 and 100 µM, while DTVP and DTVM were effective at 25, 50, and 100 µM. DTVM outperformed Tamoxifen at 50 µM in the MCF‐7 cell line. DNA damage studies of the compounds were performed using the comet assay method.The findings indicated that cell death occurred via a DNA damage mechanism. The molecular intricacies of DTVA, DTVG, DTVM, DTVP and DTVV within the VEGFR2 kinase domain and Cyclophilin_CeCYP16‐Like Domain binding pockets and various interactions, docking scores and potential activities of these derivatives were investigated. The differences in docking scores and interaction profiles highlight the potential efficacy and specificity of these compounds in targeting breast and colon cancer cells. These findings highlight the potential of phosphazene‐peptide derivatives as therapeutic agents in cancer treatment.

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Polyphosphazenes—A Promising Candidate for Drug Delivery, Bioimaging, and Tissue Engineering: A Review

Ilayaperumal¹,

Chelladurai²,

Vairan³

et al. 2023

Macro Materials & Eng

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Synthetic polymer materials have been surged to the forefront of research in the fields of tissue engineering, drug delivery, and biomonitoring in recent years. Biodegradable synthetic polymers are increasingly needed as transient substrates for tissue regeneration and medicine delivery. In contrast to commonly used polymers including polyesters, polylactones, polyanhydrides, poly(propylene fumarates), polyorthoesters, and polyurethanes, biodegradable polyphosphazenes (PPZs) hold great potential for the purposes indicated above. PPZ's versatility in the synthetic process has enabled the production of a variety of polymers with various physico-chemical, and biological properties have been produced, making them appropriate for biomedical applications. Biocompatible PPZs are often used as scaffolds in the regeneration of skeleton, bones, and other tissues. PPZs have also received special attention as potential drug vehicles of high-value biopharmaceuticals such as anticancer drugs. Additionally, by incorporating fluorophores into the PPZ backbone to produce photoluminescent biodegradable PPZs, the utility of polyphosphazenes is further expanded as they are used in tracking the regeneration of the target tissue as well as the fate of PPZ based scaffolds or drug delivery vehicles. This review provides a summary of the evolution of PPZ applications in the fields of tissue engineering, drug delivery, and bioimaging in recent 5 years.

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Polyphosphazene polymers: The next generation of biomaterials for regenerative engineering and therapeutic drug delivery

Cited by 34 publications

References 93 publications

Biomedical applications of polyphosphazenes

Biomedical applications of polyphosphazenes

Phosphazene Tripeptide Conjugates: Design, Synthesis, In Vitro Cytotoxicity and Genotoxicity, Molecular Interactions in Binding Pockets on Human Breast and Colon Cancer Cell Lines

Polyphosphazenes—A Promising Candidate for Drug Delivery, Bioimaging, and Tissue Engineering: A Review

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