Polyphyllin I modulates MALAT1/STAT3 signaling to induce apoptosis in gefitinib-resistant non-small cell lung cancer

Yang, Qi; Chen, Wenyu; Xu, Yuanzhi; Liu, Xiaodong; Zhang, Ming; Jiang, Hao

doi:10.1016/j.taap.2018.07.031

Cited by 63 publications

(35 citation statements)

References 42 publications

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“…The compounds of polyphyllin I, polyphyllin II, gracillin and dioscin, which are quality control markers of PR, present excellent antitumor activity in recent reports [41][42][43][44][45][46]. In this work, the content of polyphyllin I, polyphyllin II, gracillin and dioscin increased signi cantly in PR after processing, showing consistence with the fact that PPR exhibited a stronger effect on tumor cell lines than CPR in both MTT assay and scratch test.…”

Section: Discussionsupporting

confidence: 75%

A Simple and Economic Limewater-based Conversion of Spirostanol Saponins: Using Paridis Rhizoma as a case study

Yu¹,

Bu²,

Shen³

et al. 2020

Preprint

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Background Green and economic conversion of spirostanol saponins in the plant is considered as an attracting area in pharmaceutical applications. We aimed to provide a practical paradigm named limewater-based conversion of spirostanol saponins (LCSS), meanwhile, a widely-used traditional Chinese herbal medicine, Paridis Rhizoma (PR), was selected as a case study. Methods Based on single factor experiments, response surface methodology (RSM) using a Box-Behnken design (BBD) was employed to optimize processing time, limewater concentration and solvent volume to obtain a maximum total saponins yield from PR. H1299, A549 and HeLa cell lines was carried out to check pharmacological effect of Crude Paridis Rhizoma (CPR) and Processed Paridis Rhizoma (PPR), and the technology was reconfirmed by another herbal medicine, Anemarrhenae Rhizoma (AR). Results The optimal conditions were: processing time of 24 h, limewater concentration of 0.12% limewater and solvent volume of 60 mL/30 g. Under these conditions, the contents of polyphyllin VII, polyphyllin II, dioscin, gracillin, and polyphyllin I had 1.131 ± 0.448, 1.835 ± 0.479, 1.430 ± 0.550, 1.761 ± 0.571 and 1.668 ± 0.360 times increasing in four batches of PR, which was responsible for the increasing of total spirostanol saponins (TSS) in PPR. In addition, the extracts of PPR exhibited stronger antitumor potential than that of CPR on H1299, A549 and HeLa cell lines based on MTT test and cell scratch test. The efficiency of proposed LCSS was then reconfirmed by Anemarrhenae Rhizome (AR), indicating its capacity in broader application. Conclusion This study depicted a LCSS strategy that may have great potential in achieving effective and economic improvement of spirostanol saponin accumulation in herbal medicines.

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Section: Discussionsupporting

confidence: 75%

A Simple and Economic Limewater-based Conversion of Spirostanol Saponins: Using Paridis Rhizoma as a case study

Yu¹,

Bu²,

Shen³

et al. 2020

Preprint

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“…HULC silencing suppressed angiogenesis by regulating ESM-1 via the PI3K/Akt/mTOR signaling pathway in human gliomas [34]. Recently, a growing number of novel treatment strategies, such as compounds derived from natural products, have been developed for cancer therapy by targeting lncRNAs [35][36][37]. Previous study reported that β-elemene inhibited the growth of esophageal cancer by modulating lncRNA-mediated inhibition of hTERT [38].…”

Section: Discussionmentioning

confidence: 99%

β-Elemene suppresses tumor growth of diffuse large B-cell lymphoma through regulating lncRNA HULC-mediated apoptotic pathway

Gao

2020

Bioscience Reports

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Background: Diffuse large B-cell lymphoma (DLBCL) is considered the most common aggressive subtype of lymphoma. A number of DLBCL patients fail to achieve a response to currently available therapies or develop resistance. β-Elemene is derived from herb Curcuma wenyujin, and exhibits anti-tumor activity in both solid and non-solid tumors through modulating several molecular signaling pathways. We aimed to explore the role of β-elemene in DLBCL treatment and elucidate the involved mechanism. Materials and methods: Cell viability, apoptosis and expressions of related proteins were assessed and in vivo study were performed to determine the tumor suppressive effect of β-elemene and explore the molecular mechanisms. Results: β-Elemene significantly suppressed the viability of DLBCL cells, and β-elemene down-regulated the lncRNA HULC expression and regulated key pro-apoptotic and anti-apoptotic proteins to induce significant apoptosis of DLBCL cells. HULC overexpression could decrease the β-elemene induced apoptosis, while HULC knockdown increased the apoptosis in DLBCL cells. In vivo study further confirmed that β-elemene could suppress the growth of DLBCL xenograft and regulate the HULC expression and the critical proteins of the apoptotic pathway. Conclusion: β-Elemene performs as a tumor suppressor and modulator of HULC-mediated apoptotic pathway in DLBCL and will be an alternative candidate for clinical application.

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“…[74][75][76][77][78][79][80][81][82][83] In the MDP, PPI inhibits Bcl-2 [74][75][76][77][78][79] and Bclxl 75 while activating Bax 74,75,78 and Bak, 75 triggering Cyt-c release from the mitochondria to the cytosol. 61,78,79 The PPI-induced release of Cyt-c in the cytosol activates caspase-9, 61,82,83 caspase-3, [74][75][76][77]80,82 and PARP. 61,[74][75][76]80,82 The activated PARP enters the nucleus and causes DNA damage, leading to cell apoptosis.…”

Section: Mitochondrial-dependent Pathwaymentioning

confidence: 99%

Natural Polyphyllins (I, II, D, VI, VII) Reverses Cancer Through Apoptosis, Autophagy, Mitophagy, Inflammation, and Necroptosis

Ahmad¹,

Gamallat²,

Khan³

et al. 2021

OTT

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Cancer is the second leading cause of mortality worldwide. Conventional therapies, including surgery, radiation, and chemotherapy, have limited success because of secondary resistance. Therefore, safe, non-resistant, less toxic, and convenient drugs are urgently required. Natural products (NPs), primarily sourced from medicinal plants, are ideal for cancer treatment because of their low toxicity and high success. NPs cure cancer by regulating different pathways, such as PI3K/AKT/mTOR, ER stress, JNK, Wnt, STAT3, MAPKs, NF-kB, MEK-ERK, inflammation, oxidative stress, apoptosis, autophagy, mitophagy, and necroptosis. Among the NPs, steroid saponins, including polyphyllins (I, II, D, VI, and VII), have potent pharmacological, analgesic, and anticancer activities for the induction of cytotoxicity. Recent research has demonstrated that polyphyllins (PPs) possess potent effects against different cancers through apoptosis, autophagy, inflammation, and necroptosis. This review summarizes the available studies on PPs against cancer to provide a basis for future research.

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Polyphyllin I modulates MALAT1/STAT3 signaling to induce apoptosis in gefitinib-resistant non-small cell lung cancer

Cited by 63 publications

References 42 publications

A Simple and Economic Limewater-based Conversion of Spirostanol Saponins: Using Paridis Rhizoma as a case study

A Simple and Economic Limewater-based Conversion of Spirostanol Saponins: Using Paridis Rhizoma as a case study

β-Elemene suppresses tumor growth of diffuse large B-cell lymphoma through regulating lncRNA HULC-mediated apoptotic pathway

Natural Polyphyllins (I, II, D, VI, VII) Reverses Cancer Through Apoptosis, Autophagy, Mitophagy, Inflammation, and Necroptosis

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