Polyploidy in islets of normal and diabetic humans

Pohl, M.; Swartz, Frank J.; Carstens, Per H.B.

doi:10.1016/s0046-8177(81)80106-2

Cited by 14 publications

(3 citation statements)

References 4 publications

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“…NSZ animals.6' This finding is similar to that in the dbldb mouse57r58 and in diabetic man. 59 Although there is regeneration of the B-cell after the SZ insult, there still remains the puzzle as to why the B-cell mass does not return to normal. In a series of experiments we gave 10-wk-old male animals dexamethasone (0.125 mglkg intramuscularly) for 13 days.61 In control animals treated with dexamethasone there was an increase in islet size, B-cell number per islet, and pancreatic insulin concentration as compared with controls not reoeiving steroids.…”

Section: A Neonatal Streptozocin Modelmentioning

confidence: 99%

Experimental reduction of B‐cell mass: Implications for the pathogenesis of diabetes

Weir

Leahy

Bonner-Weir

1986

Diabetes Metab. Rev.

141

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Section: A Neonatal Streptozocin Modelmentioning

confidence: 99%

Experimental reduction of B‐cell mass: Implications for the pathogenesis of diabetes

Weir

Leahy

Bonner-Weir

1986

Diabetes Metab. Rev.

141

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“…Histopathologists also reported an intercellular heterogeneity in the DNA content, demonstrating the presence of diploid, tetraploid, and octaploid beta cells in the human pancreas; this was not the case for other endocrine islet cells [ 23 ]. Polyploid beta cells have also been noticed in normal mice, and found to increase in percentage following prolonged hyperglycemia [ 24 ]; a subsequent study in human organs also showed higher percentages in long-standing diabetes [ 25 ]. The functional significance of polyploidy in beta cells has so far not been studied.…”

Section: Types Of Heterogeneity In the Pancreatic Beta-cell Populatiomentioning

confidence: 99%

Heterogeneity in the Beta-Cell Population: a Guided Search Into Its Significance in Pancreas and in Implants

et al. 2017

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Purpose of ReviewIntercellular differences in function have since long been noticed in the pancreatic beta-cell population. Heterogeneity in cellular glucose responsiveness is considered of physiological and pathological relevance. The present review updates evidence for the physiologic significance of beta-cell heterogeneity in the pancreas. It also briefly discusses what this role would imply for beta-cell implants in diabetes.Recent FindingsOver the past 3 years, functionally different beta cells have been related to mechanisms that may underlie their heterogeneity in the pancreas, such as the stage in their life cycle and the degree of their clustering to islets with varying vascularization. Markers were identified for detecting these subpopulations in tissues.SummaryThe existence of a functional heterogeneity in the pancreatic beta-cell population is further supported. Views on its origin and methods for its analysis in pancreas and implants will help guide the search into its significance in beta-cell biology, pathology, and therapy.

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“…immunohistochemical and semiquantitative study of the pancreatic islet cells containing macronuclei in 14 infants with persistent neonatal hypoglycemia (PN H) and 6 IDM.…”

Section: Introductionmentioning

confidence: 99%

An immunohistochemical Study of Islet Cells with Macronuclei in Infancy

Drut

1987

Pediatric Pathology

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The presence of hypertrophic islet cells in infancy as evidenced by nuclear enlargement (2 to 6 times normal size) has been mentioned as a morphological accompaniment of hyperinsulinemic hypoglycemia of infancy. We report an immunohistochemical and semiquantitative study of hypertrophic islet cells in 14 infants with neonatal hypoglycemia (10 with documented persistent neonatal hypoglycemia and 4 with probable persistent neonatal hypoglycemia) and 6 infants born to diabetic mothers (IDM), using an indirect immunoperoxidase methods for the demonstration of insulin, somatostatin, and glucagon. Quantitation of immunoreactivity was performed in each case on 20 hypertrophic cells. Polyploid cells were positive for insulin and somatostatin but negative for glucagon; insulin-positive cells outnumbered somatostatin-positive cells in both groups. As nuclear hypertrophy is considered to be a sign of hyperfunction, our findings are in accordance with the concept that IDM involves reactive beta-cell hypertrophy and similar findings in the pancreases of infants with persistent neonatal hypoglycemia (PNH) suggest a primary dysfunction of their beta cells, too.

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Polyploidy in islets of normal and diabetic humans

Cited by 14 publications

References 4 publications

Experimental reduction of B‐cell mass: Implications for the pathogenesis of diabetes

Experimental reduction of B‐cell mass: Implications for the pathogenesis of diabetes

Heterogeneity in the Beta-Cell Population: a Guided Search Into Its Significance in Pancreas and in Implants

An immunohistochemical Study of Islet Cells with Macronuclei in Infancy

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