Polypoid Colonic Hamartomatous Inverted Polyp

Tanaka, Shouichi; Iwamuro, Masaya; Kubota, Junichi; Goubaru, Motohiro; Ohta, Takeyuki; Ogata, Masatoshi; Murakami, Ichiro

doi:10.1111/j.1443-1661.2007.00674.x

Cited by 4 publications

(5 citation statements)

References 6 publications

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“…Tanaka et al [ 8 ] reported a polypoid colonic hamartomatous inverted polyp. Hamartomatous inverted polyps are benign masses formed by an inverted or downward growth of mucosal glands through the muscularis mucosa into the submucosa, occurring in the rectum.…”

Section: Discussionmentioning

confidence: 99%

Inverted Lymphoglandular Polyp in Descending Colon

Zhou

Chandrasoma

2015

Case Reports in Pathology

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A 47-year-old male with a history of left colon cancer, status post left colon resection for 12 years, presented with rectal bleeding. Colonoscopic examination revealed an 8 mm sessile polyp in the proximal descending colon. Microscopic examination showed that the surface of this polyp was covered with a layer of normal colonic mucosa with focal surface erosion. In the submucosal layer, an intimate admixture of multiple cystically dilated glands and prominent lymphoid aggregates with germinal centers was seen. The glands were lined by columnar epithelium. Immunohistochemical staining showed the glands were positive for CK20 and CDX2 and negative for CK7, with a low proliferative index, mostly consistent with reactive colonic glands. The patient remained asymptomatic after one-year follow-up. A review of the literature shows very rare descriptions of similar lesions, but none fits exactly this pattern. We would designate this inverted lymphoglandular polyp and present this case to raise the awareness of recognizing this unusual histological entity.

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Section: Discussionmentioning

confidence: 99%

Inverted Lymphoglandular Polyp in Descending Colon

Zhou

Chandrasoma

2015

Case Reports in Pathology

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“…The first report described three cases of this polyp in the rectum; however, almost all cases subsequently reported have been of the stomach. Apart from the first report, only one case of this polyp in the colorectum has been reported in English to date . We have shown the fifth case of hamartomatous inverted polyp in the colorectum along with its immunohistochemical characteristics.…”

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confidence: 56%

“…Apart from the first report, only one case of this polyp in the colorectum has been reported in English to date. 2 We have shown the fifth case of hamartomatous inverted polyp in the colorectum along with its immunohistochemical characteristics. Next, we provide a discussion about its differential diagnoses, particularly from Peutz-Jeghers-type hamartomatous polyps and inverted hyperplastic polyps.…”

Section: To the Editormentioning

confidence: 85%

Hamartomatous inverted polyp of the sigmoid colon: A case demonstrating its immunohistochemical characteristics

Hashimoto

Negishi

Ohata

et al. 2018

Pathology International

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“…Polypoid colonic hamartomatous inverted polyp is a benign lesion of the rectum, due to an inverted or downward growth of mucosal glands through the muscularis mucosa into the submucosa[46]. Microscopically, a circumscribed group of ectopic distorted, slightly atypical mucus glands are present in the submucosa, pushing the mucosa up to form a polypoid mass[50]. Epithelial eosinophilia and lymphoid aggregates are not a feature of this lesion.…”

Section: Discussionmentioning

confidence: 99%

Gut-associated lymphoid tissue or so-called “dome” carcinoma of the colon: Review

McCarthy

Chetty

2019

WJGO

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AIM To present a comprehensive review of the etiology, clinical features, macroscopic and pathological findings, and clinical significance of Gut-associated lymphoid tissue or “dome” carcinoma of the colon. METHODS The English language medical literature on gut- or gastrointestinal-associated lymphoid tissue (GALT) or “dome” carcinoma of the colon was searched and appraised. RESULTS GALT/dome-type carcinomas of the colon are thought to arise from the M-cells of the lymphoglandular complex of the intestine. They are typically asymptomatic and have a characteristic endoscopic plaque- or “dome”-like appearance. Although the histology of GALT/dome-type carcinomas displays some variability, they are characterized by submucosal localization, a prominent lymphoid infiltrate with germinal center formation, tumor-infiltrating lymphocytes, absence of desmoplasia, and dilated glands lined by columnar epithelial cells with bland nuclear features and cytoplasmic eosinophilia. None of the patients reported in the literature with follow-up have developed metastatic disease or local recurrence. CONCLUSION Increased awareness amongst histopathologists of this variant of colorectal adenocarcinoma is likely to lead to the recognition of more cases.

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Polypoid Colonic Hamartomatous Inverted Polyp

Cited by 4 publications

References 6 publications

Inverted Lymphoglandular Polyp in Descending Colon

Inverted Lymphoglandular Polyp in Descending Colon

Hamartomatous inverted polyp of the sigmoid colon: A case demonstrating its immunohistochemical characteristics

Gut-associated lymphoid tissue or so-called “dome” carcinoma of the colon: Review

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