Polyposis coli associated with adenocarcinoma of the gallbladder. Report of a case

Bombí, Josep Antoni; Rives, A; Cardesa, Antonio; Astudillo, E.; Pera, C

doi:10.1002/1097-0142(19840601)53:11<2561::aid-cncr2820531132>3.0.co;2-r

Cited by 18 publications

(1 citation statement)

References 15 publications

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“…Sie werden bei Vorliegen von Osteomen, Fibromen, Epidermoidzysten und Desmoidtumoren als Gardner-Syndrom, bei Kombination mit multiplen kartilaginären Exostosen, Talgzysten sowie neuro-epithelialen Geschwülsten des ZNS als Zanca-, Oldfield-und Turcot-Syndrom bezeichnet (4,9,13,26,32,35,37,39,. Darüber hinaus sind Einzelbeobachtungen mit retroperitonealer Fibrose und Adenokarzinomen der Gallenblase oder ableitenden Gallenwege bekannt geworden (2,7). Zudem wurde kürzlich über das gehäufte Vorkommen von Hepatoblastomen bei Kindern in Polyposis-Familien berichtet (23).…”

Section: Die Sonstigen Routinemäßig Bestimmten Laborchemischenunclassified

Die familiäre Adenomatosis coli - eine obligate Präkanzerose

Knöpfle¹,

Födisch²,

Gharib³

et al. 1985

Klin Padiatr

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The presented paper includes the medical records of five children with familial adenomatous polyposis coli on the one hand and the detailed description of the pathologic findings of the disease on the other hand. Particular emphasis is given to the morphologic criteria of the disorder predisposing the affected individuals to development of colorectal cancer at unusually early ages. In the current cases there was a so-called classical presentation of diffuse polyposis in the early and late childhood respectively. The diagnosis was established in supposedly unaffected siblings due to colonoscopy and radiologic procedures. Prophylactic total colectomy was performed in all proven cases. The association with extracolonic tumours has proved to be a remarkable feature of the disease. This fact is especially stressed.

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Section: Die Sonstigen Routinemäßig Bestimmten Laborchemischenunclassified

Die familiäre Adenomatosis coli - eine obligate Präkanzerose

Knöpfle¹,

Födisch²,

Gharib³

et al. 1985

Klin Padiatr

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Tumours of the liver, bile ducts, pancreas and duodenum in a single patient with familial adenomatous polyposis

Spigelman

Farmer

Moon

et al. 1991

Journal of British Surgery

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Management of the transected pancreas following distal pancreatectomy. Surg Gvnecol Obstet 1982; 154: 225-31. Lansing PB, Browder IW. Harkness SO, Kitahama A. Staple closure of the pancreas. Am Surg 1983; 49: 214-17. Scott-Conner CEH, Dawson DL. Technical considerations in distal pancreatectomy with splenic preservation. Sury Gynecol Obstet 1989; 168: 451-3. Sadek S, Holdsworth R, Cuschieri A. Experience with pancreatic banding: results of a simple techniqde for dealing with the pancreatic remnant after distal partial pancreatectomy. Br J Surg 13. Longmire WP, Jordan PH, Briggs JD. Experience with resection of the pancreas in the treatment of chronic relapsing pancreatitis. Ann Sury 1956; 144: 681-95. 14. Leger L. Technique de la pancreato-jejunostomie apres pancreatectomie gauche pour pancreatite chronique. J Chir (Paris) 1958; 76: 4J-115. Patcher HL, Pennington R. Chassin J, Spencer FC. Simplified distal pancreatectomy with the Auto Suture stapler: preliminary clinical observations. Surgery 1979; 85: 16670. Anderson DK, Bolman RM 111, Moylan JA Jr. Management of penetrating pancreatic injuries; subtotal pancreatectomy using the Auto Suture stapler.

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Gallbladder dysplasia in patients with familial adenomatous polyposis

Nugent

Spigelman

Talbot

et al. 1994

Journal of British Surgery

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Patients with familial adenomatous polyposis (FAP) are at increased risk of dying from upper gastrointestinal malignancy'.Common tumours are adenoma and adenocarcinoma involving the duodenum and ampulla of Vater. O f patients with FAP, 90 per cent have adenomas in the duodenum, with marked periampullary clustering, but the incidence of adenoma or dysplasia within the biliary tree itself is unknown and diilicult to assess. There have been case reports of polyps and cancer in the gallbladder2, bile ducts3 and liveP, supporting the hypothesis that mucosa exposed to bile in patients with FAP is at risk of undergoing adenomatous and malignant transformation.The prevalence of dysplasia in the gallbladder of a group of patients with FAP who had undergone cholecystectomy is reported. Patients and methodsThe St Mark's Polyposis Registry keeps a record of all patients with FAP who have undergone cholecystectomy. The blocks and slides of patients undergoing cholecystectomy at St Mark's Hospital were retrieved. Of those not undergoing treatment at St Mark's, if the year and place of the operation were known, a letter was sent to the pathology department requesting copies of the slides and reports. When the year was known but the hospital was not, local hospitals were approached. When no details were available and the patient had died, no further action was taken. There was only a small portion of gallbladder available for histological assessment as the whole organ was not retained by any pathology department.Each set of slides was reviewed by a single histopathologist (I.C.T.) for epithelial dysplasia, microadenoma, adenomatous polyps and carcinoma. Whenever possible, the stage of duodenal polyposis and histology assessed at upper gastrointestinal endoscopy, together with Paper accepted 7 May 1993 the presence or absence of gallstones, were also noted. The Spigelman stage of duodenal polyposis was calculated using scores for the number, size, degree of dysplasia and histological architecture of polyps, and was graded from stage 0 to IV, where stage IV represents severe disease'. ResultsA total of 25 cholecystectomies in patients with FAP were registered between 1965 and 1991. The mean age of patients was 48 years and 16 were female. Ten operations were performed at St Mark's, ten hospitals supplied slides and no slides were available in five.Gallbladder dysplasia was seen in eight of 20 patients, comprising two examples of flat epithelial dysplasia, four of microadenoma and two of adenomatous polyps (3 x 2 cm and 0.5 x 0.5 cm in size). One adenoma was villous with moderate dysplasia, the other tubular with mild dysplasia The remaining 12 specimens showed no epithelial abnormality.Age, sex, presence of gallstones, pathology department (St Mark's versus elsewhere) and the stage of duodenal polyposis were not related to the finding of gallbladder dysplasia (Table I). DiscussionIn this series of 20 gallbladder specimens from patients with FAP, 40 per cent had epithelial dysplasia. This must be an underestimate of the true incide...

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Polyposis coli associated with adenocarcinoma of the gallbladder. Report of a case

Cited by 18 publications

References 15 publications

Die familiäre Adenomatosis coli - eine obligate Präkanzerose

Die familiäre Adenomatosis coli - eine obligate Präkanzerose

Tumours of the liver, bile ducts, pancreas and duodenum in a single patient with familial adenomatous polyposis

Gallbladder dysplasia in patients with familial adenomatous polyposis

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