Polypous rhinosinusitis in the children

Карпова, Е. П.; Emelyanova, M. P.; Тулупов, Д. А.

doi:10.17116/otorino201681270-73

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…Some authors point that hypertrophic and hyperplastic changes in the sinonasal mucosa are observed mainly in people over the age of 40 [ 12 ]. However, our studies and reports by others indicate that the debut of hypertrophy and hyperplasia can also occur in childhood, although there is no verified data on the prevalence of this pathology in children [ 3 , 13 , 14 ]. According to Karpova et al [ 14 ], in children, polyposis-associated changes in the mucosa of the nose and paranasal sinuses are mainly due to AR.…”

Section: Introductioncontrasting

confidence: 61%

Periostin as a Biomarker of Allergic Inflammation in Atopic Bronchial Asthma and Allergic Rhinitis (a Pilot Study)

Krasilnikova¹,

Tush²,

Frolov³

et al. 2020

Sovrem Tehnol Med

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The involvement of periostin in Th2-dependent allergic inflammation has been documented. However, the significance of periostin as a biomarker of local allergic inflammation in the nasal mucosa (NM) of patients with atopic bronchial asthma (BA) and allergic rhinitis (AR) is yet to be determined. The aim of the study was to determine the presence of periostin and evaluate its role as a non-invasive marker of allergic inflammation in the nasal secretions of children with atopic BA and AR. Materials and Methods. In 43 patients aged 4–17 years with atopic BA and AR, the NM was examined using nasal video-endoscopy and (if indicated) computed tomography; the amount of periostin in the nasal secretion was determined by the enzyme immunoassay. Results. Exacerbation of AR was accompanied by a statistically significant increase in the level of periostin in the nasal secretion: up to 0.84 [0.06; 48.79] ng/mg, whereas in remission, that was 0.13 [0.00; 0.36] ng/mg; p=0.04. This value increased progressively as the severity of AR increased from 0.16 [0.00; 0.36] ng/mg in the mild course to 0.20 [0.00; 9.03] ng/mg in AR of moderate severity, and to 10.70 [0.56; 769.20] ng/mg in most severe cases; p=0.048. Hypertrophy or polyposis of the nasal and/or paranasal mucosa was detected in 34.9% (15/43) of the examined patients. The concentration of periostin in the nasal secretion was lower in children without NM hypertrophy: 0.18 [0.001; 4.30] ng/mg vs 0.78 [0.13; 162.10] ng/mg in patients with NM hypertrophy; the differences were close to statistically significant: p=0.051. The level of nasal periostin depended on the clinical form of hypertrophy in the sinonasal mucosa, reaching 0.17 [0.00; 0.32] ng/mg in children with polyposis hyperplasia of NM and 21.6 [10.70; 1516.80] ng/mg — with hypertrophy of the NM in the medial surface of the concha; p=0.02. Conclusion. Exacerbation and increased severity of AR in patients with atopic BA are accompanied by an increased level of periostin in the nasal secretion. This allows us to consider the level of nasal periostin as a biomarker of local allergic inflammation in the NM of patients with atopic BA combined with AR. Hypertrophic changes in the sinonasal mucosa are generally accompanied by an increased level of nasal periostin; specifically, this level significantly depends on the clinical form of mucous membrane hypertrophy and requires additional studies.

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Section: Introductioncontrasting

confidence: 61%

Periostin as a Biomarker of Allergic Inflammation in Atopic Bronchial Asthma and Allergic Rhinitis (a Pilot Study)

Krasilnikova¹,

Tush²,

Frolov³

et al. 2020

Sovrem Tehnol Med

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Acute and chronic rhinosinusitis age characteristics

Ryazantsev,

Kirichenko,

Savlevich

et al. 2024

Vestn. otorinolaringol.

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Effect of post-COVID syndrome on the quality of life of patients with allergic rhinitis and eosinophilic phenotype of chronic polyposis rhinosinusitis

Korkmazov,

Lengina,

Korkmazov

et al. 2023

Medical Journal of the Russian Federation

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BACKGROUND.An urgent issue of modern medicine is the study of the quality of life of people with post-COVID syndrome.Particular emphasis is placed on patients with various forms of allergic rhinitis associated with comorbid conditions such as polyposis rhinosinusitis.These diseases are still common and tend to increase.In this context, the study of the effect of conservative methods of treatment of allergic rhinitis and polyposis rhinosinus on the quality of life of patients will improve the effectiveness of the therapy. AIMS: To assess the impact of post-COVID syndrome on the quality of life of patients with various forms of allergic rhinitis and eosinophilic phenotype of chronic polyposis rhinosinusitis and to determine the effectiveness of conservative therapy. MATERIALS AND METHODS: In the period from May to December 2021, a study was conducted on the quality of life in the treatment of 62 patients against the background of post-covid syndrome, of which 32 patients suffered from polypous rhinosinusitis and 30 patients with allergic rhinitis.The disease of coronavirus infection was registered 2-3 months before the visit to the otorhinolaryngologist.The comparison groups included 65 people, including 33 patients with polypous rhinosinusitis and 32 with various forms of allergic rhinitis.The Russian version of the standard SF-36 questionnaire was used to collect anamnesis.A visual analogue scale was used to measure the intensity of rhinological symptoms.All patients were examined three times: before treatment, 1 and 3 months after the course of therapy. RESULTS: A comparative analysis of the quality of life indicators of patients with various forms of allergic rhinitis and polyposis rhinosinusitis showed a direct dependence on the condition of patients after a coronavirus infection. CONCLUSIONS: The use of the assessment of quality of life indicators at the stages of treatment of patients with various forms of allergic rhinitis and polypous rhinosinusitis against the background of post-covid syndrome makes it possible to determine the effectiveness of conservative therapy and timely adjust the treatment.

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Polypous rhinosinusitis in the children

Cited by 3 publications

References 19 publications

Periostin as a Biomarker of Allergic Inflammation in Atopic Bronchial Asthma and Allergic Rhinitis (a Pilot Study)

Periostin as a Biomarker of Allergic Inflammation in Atopic Bronchial Asthma and Allergic Rhinitis (a Pilot Study)

Acute and chronic rhinosinusitis age characteristics

Effect of post-COVID syndrome on the quality of life of patients with allergic rhinitis and eosinophilic phenotype of chronic polyposis rhinosinusitis

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