Polyps and Polypoid Lesions of the Colon

Mansoor, Sharmeen; Dolkar, Tsetan; El-Fanek, Hani

doi:10.1177/1066896913481060

Cited by 6 publications

(9 citation statements)

References 19 publications

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“…It was estimated that more than 80 % of colorectal cancers arise from colorectal adenomas. Based on histological architecture, colorectal adenomas can be divided into tubular adenomas (TAs), villous adenomas (VAs), and tubulovillous adenomas (TVAs) which have a mixture of tubular and villous compounds [ 8 ]. VAs are considered to bring a higher risk of malignant transformation (40 % risk of cancer) than TAs (5 % risk of cancer) or TVAs (20 % risk of cancer) [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Sphingolipid metabolism in colorectal adenomas varies depending on histological architecture of polyps and grade of nuclear dysplasia

Kurek

Łukaszuk

Świdnicka-Siergiejko

et al. 2015

Lipids

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Incidence of colorectal cancer (CRC) is growing worldwide. Pathogenetic mechanisms responsible for its onset and progression need further clarification. Colorectal adenomatous polyps are precancerous lesions with malignant potential dependent on histological architecture and grade of nuclear dysplasia. One of the factors conditioning CRC development are abnormalities in sphingolipid metabolism. The aim of this study was to assess the levels of sphingolipids in human colorectal adenomas. The control group (C, n = 12) consisted of patients with no colonic polyps. The examined group consisted of patients with prior diagnosed colonic polyps, qualified to endoscopic polypectomy. This group was further divided due to histological architecture into tubular adenomas group (TA, n = 10), tubulovillous adenomas with low-grade dysplasia (LGD-TVA, n = 10), and tubulovillous adenomas group with high-grade dysplasia (HGD-TVA, n = 11). In tissue samples, sphingolipd metabolite contents were measured using high performance liquid chromatography (HPLC). In cases of polypoid lesions with low malignancy potential (tubular adenomas), concentration of ceramide, which is characterized by proapoptotic and anti-proliferative properties, increases compared with control group (p < 0.05), whereas content of sphingosine-1-phosphate with anti-apoptotic and stimulating cellular proliferation properties is reduced in comparison with control group (p < 0.05). On the contrary, in cases of more advanced form of adenomatous polyps (tubulovillous adenomas with high-grade dysplasia), the ceramide level decreases compared with control group (p < 0.05) while sphingosine-1-phosphate concentration is elevated (p < 0.05). We found that concentrations of pro-apoptotic ceramide are decreased and pro-proliferative S1P levels are increased in polypoid lesions with high malignancy potential, and it was the opposite in those with low malignancy potential.

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Section: Introductionmentioning

confidence: 99%

Sphingolipid metabolism in colorectal adenomas varies depending on histological architecture of polyps and grade of nuclear dysplasia

Kurek

Łukaszuk

Świdnicka-Siergiejko

et al. 2015

Lipids

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“…21 Histologically, polypoid leiomyomas arising from or limited to the muscularis mucosae are well-circumscribed nodules composed of well-differentiated smooth muscle cells. 22 Immunohistochemically, leiomyomas are positive for -smooth muscle actin, muscle specific actin, and desmin, but negative for CD34, CD117 or S100 protein. 23 In this study, no leiomyomas of the muscularis mucosae had the significant atypia that is usually seen in other leiomyomas, such as those of the uterus.…”

Section: In a Large Series Involving Two Referral Centers In The Unitedmentioning

confidence: 99%

Clinical Outcomes of Endoscopic Removal in Patients with Colorectal Polypoid Leiomyomas

Choi

Cho

Choi

et al. 2016

Korean J Gastroenterol

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Background/Aims: Although polypoid leiomyomas in the colon and rectum are rare, they are increasingly detected during colonoscopy. The aim of this study was to evaluate the efficacy and clinical outcomes of endoscopic removal for colorectal polypoid leiomyoma. Methods: Data were retrospectively collected from 22 patients with polypoid leiomyoma arising from the muscularis mucosae in the colon and rectum who underwent endoscopic removal at single referral gastrointestinal endoscopy unit. Colonoscopic findings, endoscopic removal, success rates, complication rates (bleeding or perforation), pathologic characteristics, and recurrence rates were investigated. Results: Most polypoid leiomyomas were small asymptomatic lesions less than 1 cm. The tumors were located predominantly in the left colon. Ten leiomyomas were removed using cold biopsy forceps, and 12 were resected by conventional polypectomy or endoscopic mucosal resection. All tumors arose from or involved the muscularis mucosa. There were no complications, such as bleeding or perforation. No local remnant lesions were found in 19 patients who underwent at least one follow-up colonoscopy. Conclusions: This case series represent cases of small colorectal polypoid leiomyoma that were safely removed endoscopically. An awareness of their endoscopic and clinic-pathological characteristics may provide safe treatment strategy for colonic leiomyomatous tumors of similar size in capable hands. (Korean J Gastroenterol 2016;68:179-185)

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“…El tiempo de desarrollo de los pólipos adenomatosos y su conversión a cáncer amerita el tamizaje en la población en riesgo 4,7 . Es importante determinar la prevalencia de los adenomas para la prevención, la cual se ha reportado en la literatura del 5.6 al 9.4%, así como la presencia de pólipos, que se observa en el 10 al 33.7% 2 .…”

Section: Antecedentesunclassified

Prevalencia y factores de riesgo para lesiones premalignas en pacientes menores de 55 años sometidos a colonoscopia en un hospital de tercer nivel

Jiménez-López¹,

García-Romero²,

Rojas-Illanes³

et al. 2019

CIRU

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Polyps and Polypoid Lesions of the Colon

Abstract: Polypoid lesions of the colon can be thought of to be under 3 broad categories: syndromic, mesenchymal, and epithelial.

Cited by 6 publications

References 19 publications

Sphingolipid metabolism in colorectal adenomas varies depending on histological architecture of polyps and grade of nuclear dysplasia

Sphingolipid metabolism in colorectal adenomas varies depending on histological architecture of polyps and grade of nuclear dysplasia

Clinical Outcomes of Endoscopic Removal in Patients with Colorectal Polypoid Leiomyomas

Prevalencia y factores de riesgo para lesiones premalignas en pacientes menores de 55 años sometidos a colonoscopia en un hospital de tercer nivel

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