Polypseudorotaxane-based supramolecular hydrogels consisting of cyclodextrins and Pluronics as stabilizing agents for antibody drugs

Ohshita, Naoko; Motoyama, Keiichi; Iohara, Daisuke; Hirayama, Fumitoshi; Taharabaru, Toru; Watabe, Naoki; Kawabata, Youhei; Onodera, Risako; Higashi, Taishi

doi:10.1016/j.carbpol.2020.117419

Cited by 17 publications

(5 citation statements)

References 51 publications

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“…10,11 Total molecular weights of NH 2 -PRX and NH 2 -DEX were 114 kDa and 102 kDa, respectively. The stability test of immunoglobulin G (IgG) or panitumumab was performed with reference to our previous report 12 at 500 rpm for 1 week at room temperature. Adsorption test of insulin was performed at 25°C or 4°C using glass tubes or polypropylene tubes.…”

Section: Methodsmentioning

confidence: 99%

Polyrotaxane-Based Supramolecular Material for Improvement of Pharmaceutical Properties of Protein Drugs

Kogo

Utatsu

Taharabaru

et al. 2022

Journal of Pharmaceutical Sciences

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Section: Methodsmentioning

confidence: 99%

Polyrotaxane-Based Supramolecular Material for Improvement of Pharmaceutical Properties of Protein Drugs

Kogo

Utatsu

Taharabaru

et al. 2022

Journal of Pharmaceutical Sciences

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“…Herein, polypseudorotaxane shows an efficient strategy for constructing stimulus-responsive supramolecular RTP hydrogels. 41 CDs and cucurbit [6]uril (CB [6]) to construct the supramolecular hydrogel, which showed excellent ductility and unique photoinduced color change characteristics, and was able to erase discoloration by stretching the hydrogel. 42 Liu et al reported a photocontrolled reversible multicolor RTP emission supramolecular polypseudorotaxane system constructed from CD and polyethylene glycol (PEG) derivatives modified with benzene and naphthalene as luminophores.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Therefore, it is increasingly necessary to develop supramolecular hydrogel materials with RTP emission. , The polypseudorotaxane can be formed by cyclodextrin (CD) threading the polymer chain, which is able to be used as the dominant building block of luminescent supramolecular hydrogels by utilizing the reversible encapsulation of CDs with polymer chains to achieve stimulus response. Herein, polypseudorotaxane shows an efficient strategy for constructing stimulus-responsive supramolecular RTP hydrogels . Yang et al reported luminescent dimers (6-NDI-CDs) prepared by bridging different cyclodextrins with 1,4,5,8-naphthalimide (NDI).…”

Section: Introductionmentioning

confidence: 99%

Water/Light Multiregulated Supramolecular Polypseudorotaxane Gel with Switchable Room-Temperature Phosphorescence

Liu,

Zhang,

et al. 2024

ACS Appl. Mater. Interfaces

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Water/light regulated room-temperature phosphorescence (RTP) of polypseudorotaxane supramolecular gel is constructed by threading the poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (PEG−PPG-PEG) chain with the bromoaromatic aldehyde into mono-(6-ethylenediamine-6-deoxygenated)-β-cyclodextrin (ECD) cavities and further assembling with negatively charged Laponite XLG (CNS) and diarylethene derivative (DAE) through electrostatic interaction. This hydrogel exhibits significant blue fluorescence emission; instead, after lyophilization to xerogel, the system exhibits both blue fluorescence and yellow RTP based on the rigid network structure of the xerogel, which restricts the vibration of the phosphor and suppresses the nonradiative relaxation process. Interestingly, the addition of excess ECDs to the gel system can enhance the RTP emission. Furthermore, the reversible luminescence behavior can be adjusted by the photoresponsive isomerism of DAE and humidity. This polypseudorotaxane supramolecular gel system provides a novel strategy for constructing tunable RTP materials.

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“…In CD-PPRX, several CDs thread onto the polymer chain, generating a column-like structure. Such structure formation is favored by hydrophobic and van der Waals interactions between the polymer chain and CD cavity and hydrogen bonding between the adjacent threaded CD units. , Because of its unique supramolecular structure, CD-PPRX has attracted interest as a novel drug delivery system for a wide spectrum of pharmaceuticals, from low molecular weight drugs to proteins and nucleic acids. − …”

Section: Introductionmentioning

confidence: 99%

Vapor-Phase-Mediated Encapsulation of Guest Drug Molecules in the Hexagonal Columnar Form Structure of Polyethylene Glycol/γ-Cyclodextrin-Polypseudorotaxane

Kundu

Higashi

Takamizawa

et al. 2023

Crystal Growth & Design

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The drug/(PEG/γ-CD-PPRX) complex is a unique multicomponent supramolecular structure where the drug molecules are incorporated in the intermolecular spaces of the polypseudorotaxane (PPRX) prepared from polyethylene glycol (PEG) and γ-cyclodextrin (γ-CD). Herein, we report a sealed-heating preparation method to obtain an unanticipated polymorphic form of the drug/(PEG/γ-CD-PPRX) complex, which is the hexagonal-columnar (HC) form. The encapsulation efficiency of the six guest drugs was evaluated. The crystalline structural changes and the guest encapsulation monitored by powder X-ray diffraction revealed that a low sealed-heating temperature with a small amount of water was the optimal preparation condition for obtaining the HC form complex. The solution-state 1H nuclear magnetic resonance measurement demonstrated that stoichiometric complexation was dependent on the cross-sectional area of the guest drug molecule. However, stoichiometric complexation could not be achieved with all guest drugs, and the encapsulation efficiency was found to be governed by the guest drug properties, such as vapor pressure and molecular size. The findings of this study would contribute to understanding the complexation behavior of guest molecules in multicomponent supramolecular complexes and offer new insights into the fabrication of novel ordered supramolecular structures.

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Polypseudorotaxane-based supramolecular hydrogels consisting of cyclodextrins and Pluronics as stabilizing agents for antibody drugs

Cited by 17 publications

References 51 publications

Polyrotaxane-Based Supramolecular Material for Improvement of Pharmaceutical Properties of Protein Drugs

Polyrotaxane-Based Supramolecular Material for Improvement of Pharmaceutical Properties of Protein Drugs

Water/Light Multiregulated Supramolecular Polypseudorotaxane Gel with Switchable Room-Temperature Phosphorescence

Vapor-Phase-Mediated Encapsulation of Guest Drug Molecules in the Hexagonal Columnar Form Structure of Polyethylene Glycol/γ-Cyclodextrin-Polypseudorotaxane

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