Polypyrrole-hydrogel composites for the construction of clinically important biosensors

Brahim, Sean; Narinesingh, Dyer; Guiseppi‐Elie, Anthony

doi:10.1016/s0956-5663(01)00262-7

Cited by 171 publications

(110 citation statements)

References 32 publications

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“…However, the hydrophobicity of CPs is a major limitation for successfully entrapping proteins and maintaining their bioactivity. Different approaches have been analysed to overcome this drawback, including the use of monomers that contain both redox centres and hydrophilic chains (Cosnier et al 2003), blends with polyelectrolytes (Hodgson et al 1996) and CP-HG composites (Brahim et al 2002;Brahim & Guiseppi-Elie 2005).…”

Section: Tissue Engineering Applicationsmentioning

confidence: 99%

Applications of conducting polymers and their issues in biomedical engineering

Ravichandran

Sundarrajan

Venugopal

et al. 2010

J. R. Soc. Interface.

388

253

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Conducting polymers (CPs) have attracted much interest as suitable matrices of biomolecules and have been used to enhance the stability, speed and sensitivity of various biomedical devices. Moreover, CPs are inexpensive, easy to synthesize and versatile because their properties can be readily modulated by (i) surface functionalization techniques and (ii) the use of a wide range of molecules that can be entrapped or used as dopants. This paper discusses the various surface modifications of the CP that can be employed in order to impart physico-chemical and biological guidance cues that promote cell adhesion/proliferation at the polymer-tissue interface. This ability of the CP to induce various cellular mechanisms widens its applications in medical fields and bioengineering.

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Section: Tissue Engineering Applicationsmentioning

confidence: 99%

Applications of conducting polymers and their issues in biomedical engineering

Ravichandran

Sundarrajan

Venugopal

et al. 2010

J. R. Soc. Interface.

388

253

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“…The thickness and morphology of the film are primarily controlled by the amount of electric charge passed between the counter and working electrodes. Additionally, biofunctionality can be easily imparted to CPs during electrodeposition through the incorporation of biological entities such as silk-like protein fragments (SLPF) [59], hyaluronic acid (HA) [60,61], various laminin peptides [1,2,59,62], enzymes [28,[63][64][65][66], polymeric amino acids [67,68], growth factors [2,11,69,70] and whole cells [71]. Electrodeposition is the most commonly used method for coating conventional metallic bioelectrodes.…”

Section: Conventional Cp Fabricationmentioning

confidence: 99%

Conducting polymer-hydrogels for medical electrode applications

Green

Baek

Poole-Warren

et al. 2010

Science and Technology of Advanced Materials

247

182

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Conducting polymers hold significant promise as electrode coatings; however, they are characterized by inherently poor mechanical properties. Blending or producing layered conducting polymers with other polymer forms, such as hydrogels, has been proposed as an approach to improving these properties. There are many challenges to producing hybrid polymers incorporating conducting polymers and hydrogels, including the fabrication of structures based on two such dissimilar materials and evaluation of the properties of the resulting structures. Although both fabrication and evaluation of structure-property relationships remain challenges, materials comprised of conducting polymers and hydrogels are promising for the next generation of bioactive electrode coatings.

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“…4,27 Electrochemical biosensors have been the most commonly used classes of biosensors due to their faster response, greater simplicity, and lower cost compared to optical, calorimetric, and piezoelectric biosensors. 48 The contamination of the biosensor surface has also caused some failures of electrochemical biosensors. 27 These disadvantages have continued to be solved, for instance by using a membrane that excludes interference of unwanted materials from a reaction.…”

Section: ·2 Principle Of Electrochemical Biosensorsmentioning

confidence: 99%

“…68 Electro-polymerization of pyrrole and its use for immobilization of enzymes by entrapment during polymer growth were proven to be very simple and efficient techniques for the construction of biosensors. 41,48,102 Size-exclusion properties of polypyrrole (PPy) films were highly selective against common interferences presented in biological media such as ascorbate and urate, electro-active endogenous anionic species.…”

Section: ·15 Composite Transducers For Polypyrrolementioning

confidence: 99%

“…Such polymer composite provided high biocompatibility and enhanced the rate of the electron transfer. 4,41,48 The development and optimization of glucose, cholesterol, and galactose biosensors were also studied. 48 The enzymes/hydroxyl ethyl methacrylate pyrrole mixtures were applied on the surface of platinum electrodes and immediately irradiated with UV light.…”

Section: ·15 Composite Transducers For Polypyrrolementioning

confidence: 99%

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Recent Developments, Characteristics, and Potential Applications of Electrochemical Biosensors

2004

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The objective of this study is to analyze the technical importance, performance, techniques, advantages, and disadvantages of the biosensors in general and of the electrochemical biosensors in particular. A product of reaction diffuses to the transducer in the first generation biosensors (based on Clark biosensors). The mediated biosensors or second generation biosensors use specific mediators between the reaction and the transducer to improve sensitivity. The second generation biosensors involve two steps: first, there is a redox reaction between enzyme and substrate that is reoxidized by the mediator, and eventually the mediator is oxidized by the electrode. No normal product or mediator diffusion is directly involved in the third generation biosensors, direct biosensors. Based on the type of transducer, current biosensors are divided into optical, mass, thermal, and electrochemical sensors. They are used in medical diagnostics, food quality controls, environmental monitoring, and other applications. These biosensors are also grouped under two broad categories of sensors: direct and indirect detection systems. Moreover, these systems could be further grouped into continuous or batch operation. Therefore, amperometric biosensors and their current applications are focused on more in detail since they are the most commonly used biosensors in monitoring and diagnosing tests in clinical analysis. Problems related to the commercialization of medical, environmental, and industrial biosensors as well as their performance characteristics, their competitiveness in comparison to the conventional analytical tools, and their costs determine the future development of these biosensors.

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Polypyrrole-hydrogel composites for the construction of clinically important biosensors

Cited by 171 publications

References 32 publications

Applications of conducting polymers and their issues in biomedical engineering

Applications of conducting polymers and their issues in biomedical engineering

Conducting polymer-hydrogels for medical electrode applications

Recent Developments, Characteristics, and Potential Applications of Electrochemical Biosensors

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